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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 296-298 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung 5-Hydroxytryptamin und Dopamin konnten von den Partikeln der enterochromaffinen und dopaminen Zellen und Blutplättchen in den pH-Werten 1–3 gelöst werden. Gleichzeitig wurde die Auflösung und das Verschwinden der Osmiumaffinität der Partikel festgestellt.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 27 (1984), S. 349-354 
    ISSN: 1432-1041
    Keywords: tolfenamic acid ; anti-inflammatory agents ; biliary excretion ; pharmacokinetics ; intravenous administration ; bile duct cannulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To study its pharmacokinetics and especially its biliary excretion, 14C-tolfenamic acid 9.84 µCi/100 mg was infused i.v. in 8 patients with a T-tube inserted in the common bile duct at choledocholithotomy 7–10 days prior to the study. Bile was collected in fractions by continuous suction over a 24 h period. Blood samples were taken and urine collected up to 48 h after the dose. Tolfenamic acid and its metabolites were separated by TLC and were quantitated by liquid scintillation counting. The pharmacokinetics of tolfenamic acid could be described by a two compartment open model with V1 of 3.67±0.68 l and Vss of 8.0±1.0 l. The total plasma clearance of tolfenamic acid averaged 106±8 ml/min and t1/2β was 1.38±0.32 h. A three compartment open model was required to describe the kinetics of total 14C. The plasma clearance of total 14C was 15.4±3.9 ml/min and its terminal half life averaged 19.0±4.1 h. The long half-life was caused by the slow elimination of tolfenamic acid metabolites. Four metabolites were measured in plasma and bile. The principal metabolites in bile were glucuronide/sulphate conjugates of hydroxylated derivatives of tolfenamic acid. The recovery of tolfenamic acid in bile was 1.1±0.3% of the dose, whereas the recovery of total 14C was 18.6±4.9%. The biliary clearances of tolfenamic acid and total 14C were 1.2±0.3 and 5.0±2.1 ml/min, respectively. Thus, biliary excretion plays a considerable part in the pharmacokinetics of tolfenamic acid.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 25 (1969), S. 70-72 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nach spezifischer i.v. Injektion wird gefunden, dass Dopamin und 3,4-Dioxyphenylalanin-aminosäure im Zytoplasma der Panethschen Zellen des Mäuseduodenums angehäuft sind. Während Niamid® das meist rasche Verschwinden der Formaldehyd-verursachten Aminfluoreszenz in den Granula von Panethschen Zellen verzögerte, blieb Reserpin wirkungslos.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1074-1075 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of glucagon and insulin on the paneth cells (PC) of the duodenum of the mouse was investigated using light microscopy. Both glucagon and insulin were able to increase significantly the number of the secretory granules of PC. This possibly means that these hormones are capable of inhibiting the secretion of PC.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 31 (1975), S. 577-578 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis, dass Trasylol®, ein Hemmstoff für proteolytische Enzyme, im Duodenum und Jejunum der Maus eine Zunahme der Panethschen Zellen bewirkt und ausserdem eine Vermehrung der Sekretgranula pro Zelle verursacht.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 30 (1974), S. 1460-1462 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis der ersten enterochromaffinen and dopaminen Zellen im Magendarmtraktus des Rindes während der 6. und 7. Woche der Embryonalentwicklung. Die Differenzierung der beiden Zelltypen gelang leicht mittels Fluoreszenz (Formaldehyd), topographischer Verteilung und Zellstruktur. Während die enterochromaffinen Zellen aus den Darmepithelzellen stammen, scheint es sich bei den dopaminen Zellen um Mastzellen zu handeln.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1920
    Keywords: Contrast media ; Convulsions ; Femoral neck fractures ; Myelography (adverse effects)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Convulsions and fracture of the neck of the femur following myelography with Conray and Dimer X are reported in two patients with a gross post-tuberculous gibbus deformity of the thoracic spine. The possible causes of the increased risk associated with myelography of the patients with gibbus are discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 91 (1983), S. 115-122 
    ISSN: 1437-1596
    Keywords: Head injuries ; Brain injuries ; X-ray diagnostics ; Schädelverletzungen ; Hirnverletzungen ; Röntgendiagnostik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Richtigkeit klinischer Diagnosen bei Patienten wurde untersucht, die in der Neurochirurgischen Abteilung des Zentralkrankenhauses der Universität Helsinki von 1975–76 an einer tödlichen Kopfverletzung verstorben waren. Regelrechte klinische und Röntgenuntersuchungen wurden angewandt, nicht jedoch die Computertomographie, über deren Bedeutung als ein zusätzliches Diagnosemittel später berichtet werden soll. Die meisten Patienten waren Opfer eines Verkehrsunfalles, 71% starben innerhalb von 24 h nach dem Unfall. Der Prozentsatz für richtige Diagnosen von Frakturen betrug 87% für Verletzungen der Schädeldecke, 76% für Schädelbasisbrüche und 67% für Frakturen des Gesichtsschädels. Von allen intrakranialen Verletzungen wurden 75% richtig, 9% teilweise richtig diagnostiziert. Die Diskrepanzen würden noch deutlicher werden, wenn cerebrale Kontusionen, Verletzungen und Blutungen separat aufgeschlüsselt würden. Die Studie zeigt, daß viele Kopfverletzungen durch übliche klinische Untersuchungen nicht diagnostiziert werden. Auch scheint der Wert einer Röntgenuntersuchung gering bei Post-mortem-Diagnosen von Schädelfrakturen und intrakranialen Läsionen.
    Notes: Summary The accuracy of the clinical diagnoses of the victims who died at the Department of Neurosurgery, Helsinki University Central Hospital in 1975 and 1976 of a lethal injury to the head was investigated. Standard clinical and X-ray means were used without computed tomography whose value as an additional tool will be reported later. Most of the patients were traffic accident victims of which 71% died within 24 h after trauma. The rate of the correct diagnoses of fractures was 87% in the vault, 76% at the base of the skull, and 67% in the facial bones. Of all intracranial lesions, 75% were correctly and 9% partially diagnosed. The discrepancy would have been more marked if such entities as cerebral contusion and laceration and hemorrhage had been presented separately. This study indicates that many head injuries remained undiagnosed by standard clinical means. The value of X-ray examination also appeared small in the postmortem diagnostics of skull fractures and intracranial lesions.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 108 (1996), S. 210-214 
    ISSN: 1437-1596
    Keywords: Amniotic fluid embolism ; Syncytiotrophoblastic cells ; Megakaryocytes ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The histological diagnosis of amniotic fluid embolism (AFE) is based on finding amniotic fluid components in the pulmonary microvasculature. In addition to the distinctive constituents of AFE, placental and decidual tissue fragments as well as isolated trophoblastic cells and megakaryocytes are potentially detectable within pulmonary vessels. The identification of single syncytiotrophoblastic cells (STC), and their differentiation from circulating megakaryocytes (MK) within the lumen of small and medium-sized pulmonary vessels is difficult by classical morphological methods. In a fatal case of AFE, we have successfully detected the simultaneous presence of STC and MK in the pulmonary microvasculature by means of a panel of specific monoclonal (CD61-GpIIIa, β-hCG) and polyclonal (FVIII-vW hPL) antibodies. The immunohistochemical analysis for identification of STC and MK should provide more precise data on their incidence and distribution in physiological and pathological conditions as well providing new insights into their physiopathological implications and their correlation with AFE and other gynaecological complications.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1437-1596
    Keywords: Key words Drowning ; Diatoms ; Lung ; Alveolar ; macrophages ; Scanning electron microscopy ; Transmission electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The diagnostic value of diatom analysis for drowning is considered to be one of the most controversial arguments in forensic medicine. However, the theoretical assumption of the method, i.e. the capacity of diatoms to penetrate the alveolo-capillary barrier during drowning, has never been addressed. Using scanning (SEM) and transmission electron microscopy (TEM), we have investigated the interaction of a natural population of diatoms and an unialgal culture of Phaeodactylum tricornutum (PT) with the alveolo-capillary barrier in an experimental model of drowning. The SEM analysis allowed the identification of several diatom species along the whole airways and their close interaction with the alveolar wall, but was poorly informative about the effective penetration of diatoms into pulmonary vessels. The TEM analysis was more informative and allowed a precise identification of the PT cells in alveolar spaces and to detect their phagocytosis by alveolar macrophages. PT penetrated into the pulmonary vessels through the thinnest portions of the alveolo-capillary barrier and through the interstitial spaces and were identified in pulmonary capillaries and venules. The morphological demonstration of the capacity of diatoms to penetrate the alveolo-capillary barrier is a step forward in assessing the potentiality, reliability and limitations of diatom analysis on a new basis as a tool for the diagnosis of drowning.
    Type of Medium: Electronic Resource
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