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  • 1
    ISSN: 1573-7284
    Keywords: Delta agent ; Eastern Sicily
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sera from 619 HBsAg+ subjects living in eastern Sicily, consecutively collected from 1975–1985, were tested for markers of delta virus (HDV) infection: delta antigen (HDAg), antibodies to delta (anti-HDIg), and also for antibodies to HBcore of IgM type (anti-HBcIgM) and for the system HBe-anti-HBe. The subjects included 210 asymptomatic carriers, 238 patients with acute hepatitis and 171 patients with chronic liver disease. HDAg was not found in any of the samples. Anti-HD was found in 28/171 (16.3%) patients with chronic liver disease, in 13/210 (6%) asymptomatic HBsAg carriers and in 13/238 (5.4%) patients with acute hepatitis. None of our patients were drug addicts. One had a history of blood transfusion, and nine came from the same family unit. The prevalence of HDV infection in eastern Sicily is lower than in other areas of Sicily possibly because of the lower percentage of HBsAg carriers in the local population. Parenteral transmission of HDV does not seem to play a major role in our area, while the familial clustering suggests close body contact as an important way of spread.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 209 nacheinander eingewiesenen Patienten mit chronischer Leberkrankheit (Alter 18 bis 74 Jahre) wurde die Prävalenz von anti-HCV, anti-HDV und HBV-Markern bestimmt. Anti-HCV fand sich in 69% von 155 HBsAg-negativen Patienten (55 mit chronischer Lebererkrankung und 102 mit Zirrhose). 67% dieser 155 Patienten wiesen auch anti-Hbc im Serum auf, wobei sich zwischen anti-HCV positiven und-negativen Patienten kein Unterschied feststellen ließ. Bei den 54 HBsAg-positiven Patienten fanden sich zehn (18,5%) die auch anti-HCV-positiv waren, 22 (40,7%) waren auch anti-HDV-positiv und bei 12 (22,2%) konnte im Serum HBV-DNA nachgewiesen werden. Bei einem Patienten fand sich gleichzeitig anti-HDV und anti-HCV, bei einem anderen anti-HCV und HBV-DNA im Serum. Bei 21 von 54 Patienten wurde bei Aufnahme eine Leberzirrhose festgestellt, davon waren 17 (81%) anti-HCV und/oder anti-HDV-positiv. In der Gesamtgruppe von 209 Patienten hatten 123 bei Aufnahme eine Leberzirrhose und in 107 dieser Fälle hatte HCV möglicherweise eine pathogenetische Bedeutung.
    Notes: Summary The prevalence of anti-HCV, anti-HDV and of HBV markers has been investigated in a series of 209 consecutive patients (age 18–74 years) with chronic liver disease. Among 155 HBsAg negative patients (53 chronic hepatitis cases and 102 cirrhosis cases), anti-HCV were found in 69% of the cases. 67% of the 155 patients also carried anti-HBc, with no difference between patients positive or negative for anti-HCV. Among the 54 HBsAg positive patients, 10 (18.5%) also had anti-HCV, 22 (40.7%) were anti-HDV positive and 12 (22.2%) had serum HBV-DNA. One patient had concomitant anti-HDV and anti-HCV and another presented anti-HCV and serum HBV-DNA. 21/54 patients had liver cirrhosis on presentation and among these 17 (81%) were anti-HCV and/or anti-HDV positive. On the whole, 123/209 patients had liver cirrhosis on presentation and in 107 of them HCV infection may have played a role.
    Type of Medium: Electronic Resource
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