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  • 1
    Electronic Resource
    Electronic Resource
    Purification of mitochondria and secretory granules isolated from pancreatic β cells using Percoll and Sephacryl S-1000 Superfine
    Amsterdam : Elsevier
    Analytical Biochemistry 132 (1983), S. 82-88 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(83)90428-1
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lipid-induced colonic hypersensitivity in irritable bowel syndrome: the role of 5-HT3 receptors (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 17 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Irritable bowel syndrome patients demonstrate colonic hypersensitivity after duodenal lipid infusion.Aim : To investigate the role of 5-hydroxytryptamine-3 (5-HT3) receptors in this sensory component of the gastrocolonic response in irritable bowel syndrome.Methods : Fifteen female patients with diarrhoea-predominant irritable bowel syndrome completed a trial with the 5-HT3 receptor antagonist alosetron (1 mg b.d.) or placebo (b.d.) over 15 days, followed by the alternative treatment. Each treatment period was followed by a colonic distension trial before and after duodenal lipids. Changes in colonic thresholds, tone and compliance and viscerosomatic referral pattern after lipids were compared between treatments.Results : With placebo, the colonic thresholds after lipids were significantly reduced for all studied sensations, whereas, with alosetron, the thresholds were significantly reduced only for first sensation and discomfort, but not for gas and pain. The reductions in thresholds did not differ significantly between treatments, but the pain threshold after alosetron tended to be less reduced compared with placebo (P = 0.10). The effects of lipids on tone, compliance and viscerosomatic referral pattern were unaffected by alosetron relative to placebo.Conclusions : 5-HT3 receptor antagonism reduces the lipid-induced colonic hypersensitivity in irritable bowel syndrome. However, 5-HT3 receptors do not seem to be the principal mediator, but may be a cofactor for the exaggerated sensory component of the gastrocolonic response in irritable bowel syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01399.x
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  • 3
    Electronic Resource
    Electronic Resource
    Biochemical typing of hyperlipoproteinemia. The development of a nomogram
    Amsterdam : Elsevier
    Clinica Chimica Acta 63 (1975), S. 91-93 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(75)90383-6
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Dual effects of glucose on the cytosolic Ca^2^+ activity of mouse pancreatic β-cells
    Amsterdam : Elsevier
    FEBS Letters 170 (1984), S. 196-200 
    Details
    ISSN: 0014-5793
    Keywords: Cytosolic Ca^2^+ ; Glucose ; Insulin secretion ; Quin2 ; Voltage-dependent Ca^2^+-channel
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(84)81398-8
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Direct measurements of increased free cytoplasmic Ca^2^+ in mouse pancreatic β-cells following stimulation by hypoglycemie sulfonylureas
    Amsterdam : Elsevier
    FEBS Letters 190 (1985), S. 21-24 
    Details
    ISSN: 0014-5793
    Keywords: Cytoplasmic Ca^2^+ ; Hypoglycemic sulfonylurea ; Pancreatic β-cell ; Quin2
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(85)80418-X
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  • 6
    Electronic Resource
    Electronic Resource
    Hyperinsulinaemia impairs gastrointestinal motility and slows carbohydrate absorption (1995)
    Springer
    Diabetologia 38 (1995), S. 79-85 
    Details
    ISSN: 1432-0428
    Keywords: Insulin diabetes mellitus ; gastrointestinal motility ; gastric emptying ; motilin ; hyperinsulinaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental euglycaemic hyperinsulinaemia (insulin levels 46±4 mU/l) impaired the postabsorptive gastrointestinal motility in healthy individuals; the effect being particularly pronounced in the upper gastrointestinal tract (stomach and proximal duodenum). The postprandial gastric emptying, measured with a standardized99mTc labelled meal, was also significantly delayed (t50 increased by 38% or 32 min). This was combined with a slower carbohydrate absorption (delay in peak blood glucose level about 40 min). Furthermore, during experimental hyperinsulinaemia higher blood glucose levels were seen at 120 min than at 60 min after food ingestion. This was not seen in any subject in the control study where only 0.9% NaCl was infused. Blood levels of the motility-stimulating hormone, motilin, were significantly lower during experimental hyperinsulinaemia. Thus, experimental hyperinsulinaemia impairs the gastrointestinal motility in both the postabsorptive and postprandial states. This effect is combined with a delayed carbohydrate absorption. Hyperinsulinaemia per se may thus lead to alterations in carbohydrate absorption and can also contribute to the gastrointestinal disturbances in diabetes. [Diabetologia (1995) 38: 79–85]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02369356
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Hyperinsulinaemia impairs gastrointestinal motility and slows carbohydrate absorption (1995)
    Springer
    Diabetologia 38 (1995), S. 79-85 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin diabetes mellitus ; gastrointestinal motility ; gastric emptying ; motilin ; hyperinsulinaemia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental euglycaemic hyperinsulinaemia (insulin levels 46 ± 4 mU/l) impaired the postabsorptive gastrointestinal motility in healthy individuals; the effect being particularly pronounced in the upper gastrointestinal tract (stomach and proximal duodenum). The postprandial gastric emptying, measured with a standardized 99 m Tc labelled meal, was also significantly delayed (t 50 increased by 38 % or 32 min). This was combined with a slower carbohydrate absorption (delay in peak blood glucose level about 40 min). Furthermore, during experimental hyperinsulinaemia higher blood glucose levels were seen at 120 min than at 60 min after food ingestion. This was not seen in any subject in the control study where only 0.9 % NaCl was infused. Blood levels of the motility-stimulating hormone, motilin, were significantly lower during experimental hyperinsulinaemia. Thus, experimental hyperinsulinaemia impairs the gastrointestinal motility in both the postabsorptive and postprandial states. This effect is combined with a delayed carbohydrate absorption. Hyperinsulinaemia per se may thus lead to alterations in carbohydrate absorption and can also contribute to the gastrointestinal disturbances in diabetes. [Diabetologia (1995) 38: 79–85]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050256
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Pulsed hot-wire measurements in two- and three-dimensional wall jets (1999)
    Springer
    Experiments in fluids 27 (1999), S. 210-218 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Pulsed Hot-Wire Anemometry (PHWA) measurements are performed in well defined two- and three-dimensional turbulent wall jets. For the two-dimensional wall jet the objective is to study reported differences between conventional Hot-Wire Anemometry (HWA) and Laser Doppler Anemometry (LDA) results. In the three dimensional wall jet, new improved data are provided, employing a measuring technique suitable for highly turbulent flows. This, since only hot-wire results previously have been published for this flow. The pulsed wire results show good agreement with existing Laser Doppler anemometer data in the two-dimensional wall jet, both reporting significantly higher turbulence levels in the outer region of the flow than hot-wires do. The hot-wire anemometer errors generally increase with increasing local turbulence intensity and since the three-dimensional wall jet has a higher turbulence level than its two-dimensional equivalent, the new pulsed hot-wire results improve the information available for the turbulence field in this flow significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003480050346
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