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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 29 (2004), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An unusual giant combined dermatofibroma is reported in a 34-year-old man who presented with skin-coloured swellings on the medial aspect of the left scapula. The plaque was well defined, reddish-brown and 25–30 cm in diameter. It was also tender and indurated. Several similar smaller lesions (satellites) were present around the plaque. Light microscopy of an incisional biopsy from the main lesion showed architectural features of a deep penetrating type of dermatofibroma, with xanthomatous aggregates, myxoid changes and probable myofibroblastic differentiation. Our case represents an extraordinary example of giant combined dermatofibroma with satellitosis. Despite its benign nature, a wide excision is contemplated because of its unsightly appearance and physical discomfort.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 2014-2016 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The current–voltage characteristics of logarithmic amplifiers depend considerably on the ambient temperature. A theoretical correction has been estimated considering the temperature dependence of various parameters in the diode equation. A log electrometer using light-emitting diodes has been fabricated and its I–V characteristics are obtained experimentally for calibration and also to determine the device constant. If a measurement is obtained at a temperature other than the one for which calibration has been done, the theoretical correction can be applied to get the correct value. It has been shown that the theoretically corrected readings lie within ±4% of the experimentally obtained data in the temperature range of 5–60 °C for the operating current range of 10−12–10−4 A. The alternative can be to introduce temperature compensation circuitry into the logarithmic amplifier. However, this makes the electrometer circuit more complex. The proposed theoretical correction method may find applications where space and power are at a premium and the accuracy requirement is not very stringent. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 59 (1990), S. 933-969 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Optical and quantum electronics 8 (1976), S. 83-84 
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 368 (1994), S. 660-664 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BamHI binds as a dimer to the symmetrical DNA sequence 5'-GGATCC-3', which differs from the EcoRI recognition sequence 5'-GAATTC-3' by only one base pair in each half site. Both enzymes cleave DNA at identical positions, following the 5'G on each strand. The structure of BamHI was solved by ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 14 (1974), S. 529-556 
    ISSN: 1573-2878
    Keywords: Calculus of variations ; optimal control ; computing methods ; numerical methods ; boundary-value problems ; modified quasilinearization algorithm ; nondifferential constraints
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper considers the numerical solution of optimal control problems involving a functionalI subject to differential constraints, nondifferential constraints, and terminal constraints. The problem is to find the statex(t), the controlu(t), and the parameter π so that the functional is minimized, while the constraints are satisfied to a predetermined accuracy. A modified quasilinearization algorithm is developed. Its main property is the descent property in the performance indexR, the cumulative error in the constraints and the optimality conditions. Modified quasilinearization differs from ordinary quasilinearization because of the inclusion of the scaling factor (or stepsize) α in the system of variations. The stepsize is determined by a one-dimensional search on the performance indexR. Since the first variation δR is negative, the decrease inR is guaranteed if α is sufficiently small. Convergence to the solution is achieved whenR becomes smaller than some preselected value. In order to start the algorithm, some nominal functionsx(t),u(t), π and nominal multipliers λ(t), ρ(t), μ must be chosen. In a real problem, the selection of the nominal functions can be made on the basis of physical considerations. Concerning the nominal multipliers, no useful guidelines have been available thus far. In this paper, an auxiliary minimization algorithm for selecting the multipliers optimally is presented: the performance indexR is minimized with respect to λ(t), ρ(t), μ. Since the functionalR is quadratically dependent on the multipliers, the resulting variational problem is governed by optimality conditions which are linear and, therefore, can be solved without difficulty. To facilitate the numerical solution on digital computers, the actual time θ is replaced by the normalized timet, defined in such a way that the extremal arc has a normalized time length Δt=1. In this way, variable-time terminal conditions are transformed into fixed-time terminal conditions. The actual time τ at which the terminal boundary is reached is regarded to be a component of the parameter π being optimized. The present general formulation differs from that of Ref. 3 because of the inclusion of the nondifferential constraints to be satisfied everywhere over the interval 0⩽t⩽1. Its importance lies in that (i) many optimization problems arise directly in the form considered here, (ii) there are problems involving state equality constraints which can be reduced to the present scheme through suitable transformations, and (iii) there are some problems involving inequality constraints which can be reduced to the present scheme through the introduction of auxiliary variables. Numerical examples are presented for the free-final-time case. These examples demonstrate the feasibility as well as the rapidity of convergence of the technique developed in this paper.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 16 (1975), S. 447-485 
    ISSN: 1573-2878
    Keywords: Nonlinear programming ; mathematical programming ; quadratically convergent algorithms ; conjugate-gradient methods ; variable-metric methods ; computing methods ; numerical methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The problem of minimizing a functionf(x) subject to the constraint ϕ(x)=0 is considered. Here,f is a scalar,x is ann-vector, and ϕ is anm-vector, wherem 〈n. A general quadratically convergent algorithm is presented. The conjugate-gradient algorithm and the variable-metric algorithms for constrained function minimization can be obtained as particular cases of the general algorithm. It is shown that, for a quadratic function subject to a linear constraint, all the particular algorithms behave identically if the one-dimensional search for the stepsize is exact. Specifically, they all produce the same sequence of points and lead to the constrained minimal point in no more thann −r descent steps, wherer is the number of linearly independent constraints. The algorithms are then modified so that they can also be employed for a nonquadratic function subject to a nonlinear constraint. Some particular algorithms are tested through several numerical examples.
    Type of Medium: Electronic Resource
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