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  • 1
    Electronic Resource
    Electronic Resource
    Humoral immunity in children with proven bronchiectasis, bronchial deformations and chronic bronchitis (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 2 (1991), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In 70 children with defined chronic chest disease, immunoglobulins, IgG subclass levels and antibody concentrations specific for Haemophilus influenzae b (Hib), and pneumococcal antigen, were related to disease severity. Bronchological examinations revealed 30 children with chronic bronchitis, 21 with bronchial deformations and 19 with bronchiectasis. Of the 70 children 12 (17.1%) showed an underlying immunodeficiency. The commonest finding was an IgG subclass deficiency, 7 were IgG2 and 1 IgG3 deficient, followed by IgA deficiency in 3 patients. All patients had normal IgG and IgM levels except one who had immunodeficiency with elevated IgM. Pneumococcal antibody levels were found to increase between patient groups in the order healthy children 〈 chronic bronchitis 〈 bronchiectasis 〈 bronchial deformations (p 〈 0.01), but this was not the case for Hib antibodies. We found no selective deficiency of pneumococcal and Hib antibodies in our patients. Pathogens were detected in bronchial cultures from 10% of patients with chronic bronchitis, 33% of those with bronchial deformations and in 63% with bronchiectasis. This increase (p 〈 0.01) reflects a more severe inflammation of the respiratory tract in such patients. However, immunodeficiencies were equally distributed between patient groups. We conclude that only a subgroup of children with chronic chest disease have an underlying immunodefiency, but most patients (83%) do synthesize normal or even high antibodies in the presence of a bacterial load.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1991.tb00193.x
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  • 2
    Electronic Resource
    Electronic Resource
    Self-directedness and exploratory microteachingin an in-service elt programme
    Amsterdam : Elsevier
    System 8 (1980), S. 205-210 
    Details
    ISSN: 0346-251X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Linguistics and Literary Studies
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0346-251X(80)90002-0
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  • 3
    Electronic Resource
    Electronic Resource
    Pulmonary alveolar microlithiasis in children (1996)
    Springer
    Pediatric radiology 26 (1996), S. 33-36 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two asymptomatic Turkish sibs are presented, a 4-year-old boy and his 7-year-old sister, with pulmonary alveolar microlithiasis (PAM) confirmed by transbronchial lung biopsy and bronchoalveolar lavage. Chest radiographs and high resolution CT demonstrated widespread intra-alveolar calcifications in both lungs. The lesions were sharply defined and less than 1 mm in diameter. CT documented a high concentration of microliths along the bronchovascular bundles, the intralobular fissure and the (sub)pleural lung parenchyma. The combination of bronchoalveolar lavage and roentgenographic appearance in high resolution CT are characteristic and pathognomonic, and can confirm the diagnosis. The more severe changes in the elder sib and the radiographic controls suggest that the pulmonary disease may be progressive in our patients. The described family of consanguineous, unaffected parents with two affected and one healthy child confirmed the autosomal recessive inheritance of PAM (McKusick 265100). In addition, the affected girl had autosomal recessive Waardenburg-anophthalmia syndrome (McKusick 206920), raising the question of whether this is a chance occurrence or possibly a contiguous gene syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403701
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  • 4
    Electronic Resource
    Electronic Resource
    Differentialdiagnose pulmonaler Infektionen bei Kindern und Jugendlichen mit neoplastischen Erkrankungen (1997)
    Springer
    Monatsschrift Kinderheilkunde 145 (1997), S. 1197-1207 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Pneumonie ; Krebserkrankung ; Infektionen ; Bronchoalveolare Lavage ; Lungenbiopsie ; Key words Pneumonia ; Cancer ; Infection ; Bronchoscopy ; Lung biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The article reviews the expanding spectrum of infectious causes of pulmonary disease in children and adolescents with cancer. Emphasis is placed on three central issues: risk and diagnostic yield of bronchoscopic and bioptic diagnostic procedures, advances in the laboratory diagnosis of pulmonary pathogens, and the comprehensive clinical approach to the pediatric cancer patient with fever and pulmonary infiltrates.
    Notes: Zusammenfassung Der Beitrag gibt einen Überblick über das erweiterte Erregerspektrum sowie die nichtinfektiösen Differentialdiagnosen pulmonaler Infiltrate bei Kindern und Jugendlichen mit neoplastischen Erkrankungen. Er befaßt sich mit dem Stellenwert der zur Verfügung stehenden nichtinvasiven und invasiven diagnostischen Verfahren und neuen Methoden der speziellen Erregerdiagnostik und enthält Vorschläge für ein differenziertes diagnostisches und therapeutisches Vorgehen in der Klinik.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050220
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  • 5
    Electronic Resource
    Electronic Resource
    Megaösophagus in Kombination mit Tracheomalazie Probleme in Diagnostik und Therapie (1997)
    Springer
    Monatsschrift Kinderheilkunde 145 (1997), S. 376-381 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Tracheomalazie ; Megaösophagus ; Aspiration ; Gastroösophagealer Reflux ; Assoziierte Fehlbildungen ; Key words Tracheomalacia ; Megaesophagus ; Aspiration ; Gastroesophageal Reflux ; Associated Malformations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Tracheomalacia and megaesophagus may cause various pulmonary problems, both seperatly as well as in combination. To prevent lasting damage a causal therapy is strongly advisable. Thorough diagnosis and the exclusion of associated malformations will help to prevent a protracted course of disease and complications. Regular controll visits will ensure a long term sucess of therapy and where necessary on appropriate adjustment of therapy.
    Notes: Zusammenfassung Tracheomalazie und Megaösophagus können sowohl einzeln als auch in Kombination ursächlich für eine vielschichtige pulmonale Problematik sein. Um dauerhafte Schäden zu vermeiden, ist eine kausal orientierte Therapie zwingend erforderlich. Durch sorgfältige Diagnostik und Ausschluß assoziierter Fehlbildungen werden langwierige Therapieverläufe und Komplikationen vermieden. Regelmäßige klinische und apparative Kontrollen sichern langfristig den Therapieerfolg und ermöglichen eine rechtzeitige Anpassung des therapeutischen Prozederes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050136
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  • 6
    Electronic Resource
    Electronic Resource
    Pleuraerguß und Gasansammlung in den Lebergefäßen (1999)
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 836-837 
    Details
    ISSN: 1433-0474
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050507
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  • 7
    Electronic Resource
    Electronic Resource
    Polyamine als Stimulatoren von Genaktivitäten Eine autoradiographische Studie an Riesenchromosomen von Chironomus thummi (1974)
    Springer
    Histochemistry and cell biology 38 (1974), S. 223-228 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Inaktive Riesenchromosomen der Speicheldrüsen ausgewachsener Chironomus thummi-Larven zeigten nach 60 min Inkubation mit 0,05 N Putrescin-, Spermidin-oder Spermin-Lösung erneute Syntheseaktivitäten, die sich im Einbau von radioaktiv markiertem Uridin autoradiographisch zu erkennen geben. Diese Beobachtung wird im Zusammenhang mit der bekannten genaktivierenden Wirkung von Mg++ diskutiert. Auf der Basis zahlreicher biochemisch analoger Wirkungen von Polyaminen und Mg++ wird ein ursprünglich für die genaktivierende Wirkung von Mg++ postuliertes Modell auf Polyamine übertragen.
    Notes: Summary Inactive salivary gland giant chromosomes of full grown Chironomus thummi larvae showed after 60 min of incubation in 0.05 N putrescine, spermidine or spermine solutions autoradiographically demonstrable incorporation of radioactiv labelled uridine caused by a reactivation of RNA synthesis. This observations is discussed in relation to the known gene activating effect of Mg++, and, since polyamines and Mg++ have numerous effects in common, it is suggested that polyamines affect gene activity in a way similar to Mg++.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493120
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  • 8
    Electronic Resource
    Electronic Resource
    Impaired insulin-induced RNA synthesis secondary to a genetically defective insulin receptor (1985)
    Springer
    Human genetics 〈Berlin〉 69 (1985), S. 76-78 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The stimulation of glucose uptake and RNA synthesis by insulin was studied in cultured fibroblasts from patients with an inherited affinity defect of the insulin receptor. Additional cell cultures were set up of two patients with Alstrøm syndrome, a genetic disease with insulin resistance but normal insulin receptor, and of eight healthy individuals. In receptor-defective patients we found a corresponding defect of the insulin-mediated stimulation of RNA synthesis but a normal stimulation of glucose uptake. We conclude that both postreceptor effects are controlled by different insulin-directed mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295533
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  • 9
    Electronic Resource
    Electronic Resource
    A new Hind III restriction fragment length polymorphism in the hemophilia A locus (1987)
    Springer
    Human genetics 〈Berlin〉 76 (1987), S. 127-128 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using a fragment of the cDNA for human coagulation factor VIII as a hybridization probe, we have detected a new polymorphic Hind III site in intron 19 of the factor VIII gene. The frequency of the minor allele is 0.30. This polymorphism shows strong linkage disequilibrium with a previously described BclI polymorphism in intron 18.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284907
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  • 10
    Electronic Resource
    Electronic Resource
    Exhaled nitric oxide in childhood asthma (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 698-701 
    Details
    ISSN: 1432-1076
    Keywords: Nitric oxid ; Asthma ; Inflammation ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endogenous synthesis of nitric oxide (NO) and its presence in exhaled air was observed in various species including humans. Particularly high levels were found in adults with bronchial asthma, possibly because of the underlying pulmonary inflammatory activity. We studied oral and nasal exhaled NO by chemiluminescence in 47 children aged between 6 and 10 years. Thirty children had bronchial asthma, 17 were healthy controls. In asthmatic children oral exhaled NO was 13.4±1.4 parts per billion (ppb) (mean±SEM), nasal exhaled NO was 21.7±1.5 ppb. In healthy controls oral exhaled NO was 7.2±1.0 ppb, nasal exhaled NO was 18.2±2.2 ppb. Oral exhaled NO was significantly higher in asthmatic children compared to healthy controls (P=0.0017). Nasal exhaled NO did not differ significantly in the two groups. There was a significant negative correlation between oral exhaled NO and forced expiratory volume in 1 s (FeV1). No significant correlation between oral or nasal exhaled NO and other markers of obstructive lung function impairment, oral minute ventilation, the body mass index and the presence of upper respiratory tract infection could be found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957156
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