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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 5 (1979), S. 183-188 
    ISSN: 1432-1238
    Keywords: Dopamine ; Estimated hepatic blood flow ; Splanchnic perfusion ; Indocyanine Green single injection method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dopamine (3,4 dihydroxyphenylethylamine) increases cardiac output and in particular the renal blood flow at the expense of other regional vascular beds not yet defined. Since the results of dopamine-induced changes in splanchnic perfusion are inconsistent, the effect of 6 mcg/kg/min dopamine was studied in 9 patients early after open heart surgery. Estimated hepatic blood flow (EHBF) was calculated from the concentration-time slopes of Indocyanine Green (ICG, CardiogreenR) in arterial and hepatic venous blood following single intravenous injection. Blood volume was measured using51Cr tagged red cells. Cardiac output was determined according to the Fick method. 6 mcg/kg/min dopamine caused a mean EHBF-increase of 82%, from 492±64 to 824±80 ml/min/m2 (P〈0.001). Related to the corresponding increase in cardiac index (CI) from 2.6±0.2 to 3.8±0.3 l/min/m2 (P〈0.001), the EHBF/CI-ratio changed from 18.5 to 21.7% (P〈0.025). The arterial-hepatic venous oxygen difference was reduced from 7.40±0.53 to 4.91±0.60 Vol% (P〈0.001). It was concluded that splanchnic perfusion does not contribute to the preferential increase of renal blood flow under dopamine under the above mentioned conditions. Dopamine had the most beneficial effect on EHBF in two cases where the latter was severely reduced.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 245 (1994), S. 686-693 
    ISSN: 1617-4623
    Keywords: Yeast ; Saccharomyces cerevisiae ; Poly(ADP-ribose) polymerase ; DNA repair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The coding sequence for human poly(ADP-ribose) polymerase was expressed inducibly in Saccharomyces cerevisiae from a low-copy-number plasmid vector. Cell free extracts of induced cells had poly(ADPribose) polymerase activity when assayed under standard conditions; activity could not be detected in non-induced cell extracts. Induced cells formed poly(ADP-ribose) in vivo, and levels of these polymers increased when cells were treated with the alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). The cytotoxicity of this agent was increased in induced cells, and in vivo labelling with [3H]adenine further decreased their viability. Increased levels of poly(ADP-ribose) found in cells treated with the alkylating agent were not accompanied by lowering of the NAD concentration.
    Type of Medium: Electronic Resource
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