ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Extractable lipids from Actinomyces naeslundii, strain I, and streptococcus mutans (6715) were injected in the oral mucosa of weanling rats. Whole lipid, neutral lipid, glycolipid and phospholipid fractions were compared with synthetic tripalmitolein. The animals were sacrificed at intervals, 6 hours to 14 days, and the tissues examined histologically.Lipids from A. naeslundii resulted in an initial polymorphonuclear response, gradually replaced by lymphocytes with time. Effects on the underlying alvolar bone included disaaperance of osteoblasts, empty osteocyte lacunae, and in a few cases, bone resorption. An accumulation offibrillar debris was also seen as early as 18 hours, persisiting up to 96 hours. post-injection.Lipids from S. mutans resulted in a marked lymphocyte infiltration preceded by a very slight PMN response, similr changes in underlying bone, and no evidence of fribrillar debris. Recovery of osteoblasts along the underlying bone was slowest with the phospholipid fractions and fastest with neutral lipids seeming to correlate with their respective toxicity. The cell reaction to synthetic triplamitolien was similar to that elicited with the neutral lipid fractions but of shorter duration. In this system lipids from A. naeslundii were apparently more toxic than those from S. mutans.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1979.tb00786.x
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