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  • 1
    Electronic Resource
    Electronic Resource
    Self-Assembled Lipidporphyrin Bilayer Vesicles. Microstructure and Dioxygen Binding in Aqueous Medium (1995)
    s.l. : American Chemical Society
    Langmuir 11 (1995), S. 1877-1884 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00006a011
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients by using synthetic hinge peptide and glycopeptide probes (2004)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 9 (2004), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background and Aims:  There are many reports on the presence of an incompletely glycosylated O-linked oligosaccharide(s) on the IgA1 hinge region in some immunoglobulin (IgA) nephropathy patients. Furthermore, the production of an antibody against the naked hinge peptide portion was reported in an IgA nephropathy patient. In this report, characterization of the IgG antibody against the hinge portion was carried out by using synthetic hinge glycopeptide probes.Methods and Results:  The following synthetic hinge peptide and glycopeptides were prepared: 19mer peptide, V-P-S-T-P-P-T-P-S-P-S-T-P-P-T-P-S-P-S (designated HP), the peptide having a single α-linked GalNAc residue at positions 4, 7, 9, 11 and 15 (4 GN − 15 GN, respectively) and the same peptide having five GalNAc residues at all five positions (GN5). The mean value of the antibody activity against these probes was compared with each other. The highest activity against the naked hinge peptide (HP) and lowest activity against the fully glycosylated hinge peptide (GN5) were obvious. As attachment of GalNAc to position 4 or 11 on the peptide brought about a significant reduction of the activity against the naked hinge peptide, the P-S-T-P sequence included in both positions was thought to be the most probable site recognized by these antibodies. As an additional unexpected observation, a gender difference in this antibody activity against all the probes was found. The antibody activity in a female was significantly higher compared with that in a male.Conclusion:  Because the frequency of incidence of IgA nephropathy is known to be slightly higher in males, this gender difference might indicate a protective meaning to remove aberrantly glycosylated molecules from the patient's serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.2003.00225.x
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  • 3
    Electronic Resource
    Electronic Resource
    Microchimerism in Female Renal Transplant Recipients from Male Donors (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of urology 3 (1996), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Microchimerism in 23 female renal transplant recipients from male donors was studied using nested polymerase chain reaction (nPCR) and fluorescence in situ hybridization (FISH) to detect Y–chromosome. nPCR was a sensitive and specific assay enabling a detection rate of 1/106male/female cells, compared with a sensitivity of 1/102 by standard PCR (sPCR). None of the 23 patients with a male allograft demonstrated Y–chromosome using sPCR. In contrast, 1 3 (56.5%) patients demonstrated Y–chromosome with nPCR. Of 9 patients proven to have microchimerism by nPCR, only 3 also demonstrated Y–chromosome using FISH. The existence of B cells and CD8 cells in donor chimeric cells were proved by separation with Dynabeads class I and class II. Dynamic changes of microchimerism occurred in 4 of 5 patients. Four patients were proven to have microchimerism within a year of transplantation and the microchimerism later disappeared in 3, although the sequential change was variable in individual patients. There was no correlation between microchimerism and patients'clinical factors such as donor–specific blood transfusion, HLA matching, immunosuppression, past history of acute rejection and chronic rejection. The degree of microchimerism in renal transplant recipients was relatively low, and its existence did not seem to be compatible with long–term graft acceptance. However, further studies are required to elucidate the immunological mechanism of microchimerism, and it might be an important clue to immunological tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-2042.1996.tb00328.x
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  • 4
    Electronic Resource
    Electronic Resource
    Relationship between antibody productivity by activated human lymph node lymphocytes from lung cancer patients and lymphocyte subsets (1999)
    Springer
    Cytotechnology 29 (1999), S. 229-236 
    Details
    ISSN: 1573-0778
    Keywords: human monoclonal antibody ; lipopolysaccharide ; lymphocyte subset ; Staphylococcus aureus Cowan I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Regional lymph node lymphocytes from five patients with primary lung cancer were analyzed for subset composition, and exposed in vitro to the polyclonal human B cell mitogen Staphylococcus aureus Cowan I (SACI) or the murine B cell mitogen lipopolysaccharide (LPS) and then fused with mouse myeloma cells for investigation at the clonal level of their antibody (Ab) production and its statistical relation to the original subset composition. No correlation was found between the proportion of CD19+, CD23+, or CD3+ cells in the lymphocyte sample prior to its exposure to either SACI or LPS, and the Ab production efficiency, defined as the ratio of the number of Ab producing wells to the total number of proliferating wells. For lymphocytes exposed to LPS, however, a strong correlation (r = 0.931, p = 0.02) was observed between the Ab production efficiency and the ratio of CD8+ to CD3+ cells (CD8/CD3) in the original sample at least within the ranges studied (CD8/CD3 = 0.216–0.288). For those exposed to SACI, no correlation was found between the Ab production efficiency and the CD8/CD3 ratio (r = 0.881, p = 0.12) or the proportion of CD8+ cells (r = 0.808, p = 0.19) in the original sample. These results suggest that the repertoire of B cells responsive to LPS is different at least in part from the repertoire responsive to SACI and that the ratio CD8/CD3 could serve as a practical predictor for Ab production by human lymphocytes stimulated with LPS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008052326963
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  • 5
    Electronic Resource
    Electronic Resource
    TM-1 cells from an established human malignant glioma cell line produce PDGF, TGF-α, and TGF-β which cooperatively play a stimulatory role for an autocrine growth promotion (1994)
    Springer
    Journal of neuro-oncology 22 (1994), S. 33-44 
    Details
    ISSN: 1573-7373
    Keywords: TM-1 cells ; PDGF ; TGF-α ; TGF-β ; autocrine growth ; synergistic action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously established a human malignant glioma cell line, TM-1. TM-1 cells could proliferate in the serum-free medium. In the present study, immunochemical analysis demonstrated that platelet-derived growth factor (PDGF), transforming growth factor (TGF)-α, and TGF-β are present in the serum-free medium conditioned by growing TM-1 cells. While the cells appeared to possess a single type of binding sites for epidermal growth factor (EGF) with properties comparable to those determined for other tumor cells, the conditioned medium did not contain EGF. PDGF, TGF-α, and EGF added exogenously to serum-free media stimulated thymidine incorporation into DNA of TM-1 cells. In addition, antibodies specific for PDGF and TGF-α suppressed this activity. These results indicate autocrine and stimulatory roles of PDGF and TGF-α for the proliferation of TM-1 cells. As observed for other tumor cells, TGF-β by itself weakly suppressed thymidine incorporation by TM-1 cells. However, TGF-β employed in combination with TGF-α or EGF appeared to stimulate thymidine incorporation, suggesting that a cooperative action of TGF-β with different growth factors may be involved in the stimulatory growth regulation at least for TM-1 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01058353
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