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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 10 (1967), S. 1182-1183 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 26 (1976), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Brain homogenates from young rats were assayed for their ability to synthesize cerebrosides from radioactive UDP-galactose or UDP-glucose and ceramide. A comparison of galactose transfer with ceramides made from different 2-hydroxy acids showed that the shortest one tested (C7) was by far the best acceptor, while the poorest contained 18 carbon atoms; longer fatty acids were better than CIS. Glucosyltransferase, on the other hand, showed rather little chain length specificity or discrimination against hydroxy acid ceramides.Synthetic compounds analogous in structure to ceramides were tested as inhibitors of the sugar transferases. Some were found to act as sugar acceptors themselves, particularly amides of DL-erythro-1- phenyl-2-amino-1,3-propanediol. Some amides were good inhibitors of glucosyltransferase, particularly decanoyl norephedrine, decanoyl threo-1-phenyl-2-amino-1,3-propanediol and decenoyl phenylalaninol. The secondary amine analogous to the first of these, N-decyl norephedrine, was also very effective. No strong inhibitors of galactosyl transferase were found, although octanoyl D-threo-p-nitrophenyla- minopropanediol showed promise (42% inhibition at 0.3 mM). Octanoyl phenylalaninol was nearly as good an inhibitor; the inhibition appeared only after a lag period.It is suggested that the glucosyltransferase inhibitors might he useful in therapy of Gaucher's disease, by reducing the degradative load normally falling on glucocerebrosidase.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 12 (1969), S. 138-141 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 8 (1965), S. 550-551 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 487 (1986), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 85 (1991), S. 19-29 
    ISSN: 1435-1463
    Keywords: 5-HT2 receptor ; human postmortem brain ; schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serotonin2 (5-HT2) receptor binding was studied, using3H-spiperone as the ligand, in post-mortem brain specimens obtained from schizophrenic patients (N=11) and non-psychiatric controls (N=11). The maximum number of binding sites (Bmax) was significantly decreased in schizophrenic patients as compared to normal controls. This difference did not appear to be due to neuroleptic treatment. No difference in Kd (an inverse measure of the affinity of3H-spiperone to its binding sites) was observed between the two groups. However, studies with unmedicated schizophrenic patients are needed to draw any definite conclusion. The role of serotonergic processes in the psychobiology of schizophrenia is discussed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fluoxetine (Lilly 110140) is a potent, specific serotonin (5-HT) uptake blocker which is being tested in man for antidepressant activity. One of 9 depressed patients receiving this drug developed a dystonic reaction, parkinsonian rigidity, and increased serum prolactin levels, all signs of decreased dopaminergic activity. Homovanillic acid levels also decreased in the cerebrospinal fluid of this subject. We postulate that fluoxetine, via the increase in 5-HT activity resulting from 5-HT uptake blockade, inhibited both the nigro-striatal and tubero-infundibular dopaminergic neurons. These results provide additional evidence for a linkage between serotonergic and dopaminergic neurons in man.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1613-1614 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The concentration of progesterone as determined by radioimmunoassay varied in accordance with the phase of ovarian activity.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Heat and mass transfer 26 (1991), S. 257-263 
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es wurde eine experimentelle Untersuchung gemacht, um die Strömungseigenschaften eines Düsenstrahls zu unterschen, der auf einen Zylinder prallt. Die Geschwindigkeitsprofile und die Druckverteilungen an dem Zylinder wurden für unterschiedliche Parameter dokumentiert. Die Parameter sind die Strömungsgeschwindigkeit, Düsengröße, Abstand zwischen Zylinder und Strahlaustritt und die Exzentrizität von Zylinder und Strahlachse.
    Notes: Abstract An experimental investigation is made to study the flow characteristics of slot jet impingement on a cylinder. The velocity profiles and pressure distribution around the cylinder are reported for various parameters namely, the flow rate, width of the nozzle, distance of the cylinder from the jet exit and eccentricity of the cylinder to the jet axis.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Heat and mass transfer 27 (1992), S. 421-427 
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es wurde eine experimentelle Studie über die Strömmungscharakteristiken eines auf einem rechtwinkligen Keil auftretenden Spaltstrahls durchgeführt. Das Ziel dieser Untersuchungen ist die Studie des Strömungsverhaltens in Keilnähe, in Abhängigkeit verschiedener Parameter wie Strahlgeschwindigkeit, Spaltbreite, Entfernung der Keilspitze und Winkel zwischen Strahlachse und Keil. Diese Parameter werden systematisch variiert um deren Einfluß auf das Strömungsverhalten zu bestimmen. Die Strömung an der Keilspitze ist ähnlich der Staupunktströmung. Weit hinter der Spitze gleicht das Strömungsfeld dem eines auf einer Wand auftreffenden Strahls. In Nähe der Keilspitze sind die Änderungen des statischen Drucks in Strömungsrichtung und quer zur Strömung groß. Grund dafür sind die starke Krümmung der Strömung und die Stagnation der Strömung. Der Druckgradient in Querrichtung nimmt langsam in Strömungsrichtung ab, daher unterscheiden sich die Geschwindigkeitsprofile von den Ähnlichkeitsprofilen der Staupunktströmung und des Wandstrahls in den jeweiligen Bereichen. Die Versuche wurden für Spaltbreiten von 10, 15 und 30 mm und Keilentfernungen von 80, 120 und 240 mm durchgeführt. Der statische Druck und die Geschwindigkeitsprofile wurden mit kalibrierten scheibenförmigen Drucksonden bzw. einer Pitot-Sonde an verschiedenen Orten gemessen.
    Notes: Abstract An experimental investigation is made to study the flow characteristics of slot jet impingement on a wedge whose included angle is 90 degrees. The aim of this investigation is to study the characteristics of the flow field near the wedge surface for various parameters. The different parameters like, jet velocity, slot width, distance of wedge vertex from the jet exit and the inclination of the wedge to jet axis are systematically varied to see their effect on the flow field. The flow field near the wedge vertex is similar to stagnation point flow. Far away from the vertex, the flow field is like that of wall jet. Near the vertex, very large variations of static pressure are observed in streamwise and transverse directions. This is due to large streamwise curvature and stagnation of flow. The transverse pressure gradient slowly decays in the streamwise direction, as a result, the velocity profiles are different from the similarity profiles of stagnation point flow and wall jet in the respective regions. Experiments are conducted for slot widths of 10 mm, 15 mm and 30 mm each for the distance between slot and wedge vertex of 80 mm, 120 mm and 240 mm. The static pressure and velocity profiles are measured by calibrated disk type static pressure probe and pitot tube respectively at various streamwise locations.
    Type of Medium: Electronic Resource
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