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  • 1
    Electronic Resource
    Electronic Resource
    Axial ligands of chloroplast cytochrome b-559: Identification and requirement for a heme-crosslinked polypeptide structure (1985)
    s.l. : American Chemical Society
    Biochemistry 24 (1985), S. 3638-3645 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00335a036
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure of the labyrinth in the rat full-term placenta (1976)
    Springer
    Anatomy and embryology 149 (1976), S. 123-148 
    Details
    ISSN: 1432-0568
    Keywords: Rat-placenta ; Gap junctions ; Electron microscopy ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The placental labyrinth of the chorioallantoic placenta of the rat was studied with transmission and scanning electron microscopy. Full-term placentas were investigated after perfusion fixation from the maternal and fetal circulation, including thin-sectioning and freeze-fracturing. The labyrinthal three-dimensional structure was found not to be trabecular but spongious lamellar. We propose a division of the lamellae into three groups—the first, second, and third order. The trophoblastic layers are described in detail, showing a cellular layer I and two syncytial layers II and III. Layer I is found to be fenestrated and highly permeable. Layers II and III are connected by extended gap junction areas. It is suggested that the gap junctions function as a molecular sieve and represent the limiting barrier in diaplacental transport of the choriollantoic placenta. Fetal capillaries are fenestrated and endothelial cells are connected by tight junctions. The functional significance of the morphologic findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317893
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  • 3
    Electronic Resource
    Electronic Resource
    Intercellular junctions in the full term human placenta (1979)
    Springer
    Anatomy and embryology 158 (1979), S. 41-50 
    Details
    ISSN: 1432-0568
    Keywords: Placenta (human) ; Syncytiotrophoblast ; Intercellular junctions ; Electron microscopy ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Inter-and intrasyncytiotrophoblastic junctions within the human full term placenta were electronmicroscopically investigated using thin sections and freeze-fracturing. Narrow clefts were occasionally situated between surface areas where adjacent chorionic villi exhibited close contact. Whithin these clefts, extensive zonulae and maculae occludentes and numerous maculae adherentes were found. The zonulae occludentes showed a continuous and irregular course on the membrane surface, and the maculae occludentes were irregularly distributed over extended membrane areas. Besides these areas, maculae occludentes and maculae adherentes were observed on infoldings and invaginations of the syncytiotrophoblastic surface membrane. Investigations of the inner surface of the syncytiotrophoblastic layer, that is, the layer facing the villous stroma, also revealed invaginations joined by maculae adherentes. The functional significance of the inter-and intrasyncytiotrophoblastic junctions is discussed with respect to the differentiation of the trophoblast.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315950
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of cardiodilatin in myoendocrine cells of the cardiac atria (1984)
    Springer
    Anatomy and embryology 170 (1984), S. 123-127 
    Details
    ISSN: 1432-0568
    Keywords: Heart Atrium ; Myoendocrine cells ; Cardiodilatin ; Peptide hormone ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Region-specific antibodies against synthetic N-terminal fragments of cardiodilatin (CDD) were raised in rabbits and used for the immunohistochemical detection of this new peptide hormone in the myoendocrine cells within the cardiac atria of several species. The peroxidase-antiperoxidase (PAP) and fluorescein isothiocyanate (FITC) immunohistochemical methods gave identical results of cardiodilatin-immunoreactivity (CDD-IR) within the tissue. In addition to the porcine right atrial appendage, myoendocrine cells with CDD-IR were also detected in the left atrium of porcine heart, as well as in other species such as dog and cat. The exact localization of the immunoreactivity in specific secretory granules was mostly related to the Golgi-area which is located on both nuclear poles of auricular myoendocrine cells. The results confirm that cardiodilatin is stored in secretory granules observed through electron microscopical means. This hormone is most likely synthesized and released in myoendocrine cells, exerting its important cardiovascular effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318996
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  • 5
    Electronic Resource
    Electronic Resource
    Intercellular junctions in the full term human placenta (1980)
    Springer
    Anatomy and embryology 158 (1980), S. 167-178 
    Details
    ISSN: 1432-0568
    Keywords: Placenta (human) ; Villous stroma ; Intercellular junctions ; Endothelium ; Ultrastructure ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intercellular junctions within the villous stroma and the cytotrophoblastic layer of the human full term placenta were investigated using thin sectioning and freeze-fracturing. Numerous maculae adherentes (desmosomes) were found between the cytotrophoblast cells and the syncytiotrophoblast. This junction type was also seen connecting adjacent cytotrophoblast cells. Large gap junctions were frequently observed in contact areas of perikarya or at processes of adjacent fibroblasts. They often exhibited a peculiar pattern of their particles on the P-face of the membrane. Small rows of junctional particles were found on the P-faces of interconnected smooth muscle cells and gap junctions frequently bridged myoendothelial and interendothelial contact zones. The significance of the junctional complexes is discussed in relation to functional systems within the villous stroma of the human full term placenta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315904
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  • 6
    Electronic Resource
    Electronic Resource
    Distribution of calcitonin gene-related peptide-like immunoreactivity in the guinea pig heart (1986)
    Springer
    Anatomy and embryology 175 (1986), S. 255-260 
    Details
    ISSN: 1432-0568
    Keywords: Immunohistochemistry ; Calcitonin gene-related peptide ; Heart innervation ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of calcitonin gene-related peptide like-immunoreactivity (CGRP-IR) within the heart and adjacent blood vessels of the guinea pig was investigated anmunohistochemically by use of the peroxidase-antiperoxidase (PAP) technique. Numerous paravascular and perivascular immunoreactive nerve fibers were localized around the aorta, coronary arteries and their branches down to the teminal vasculature. Arterioles in the atria showed greatest density of immunoreactive varicosities of all blood vessels. The epicardium, endocardium and the conductive system also contained numerous CGRP-IR nerve fibers. In the muocardium the number of immunoreactive varicosities was variable. Many were present in both atria, moderate amounts were seen in the right ventricle and parts of the intraventricular septum, and only a few occurred in the left ventricle. CGRP-IR was infrequently found within intracardial ganglionic cells but was abundantly distributed in the surrounding nerve fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389603
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  • 7
    Electronic Resource
    Electronic Resource
    The right auricle of the heart is an endocrine organ (1983)
    Springer
    Anatomy and embryology 168 (1983), S. 307-313 
    Details
    ISSN: 1432-0568
    Keywords: Heart Atrium ; Myoendocrine Cells ; Cardiodilatin ; Peptide Hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new polypeptide hormone candidate regulating vascular smooth muscle function was extracted from porcine atrial tissue. The purification steps were followed by a bioassay. The hormonally active substance has been analyzed and found to be a small polypeptide exhibiting a molecular weight of about 7500 and is named “cardiodilatin” (CDD). Further chemical data on this new hormone will be published elsewhere. A partial amino acid sequence of cardiodilatin is offered and shows that among the well known hormones or neuropeptides, none exhibit a homologue partial sequence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304269
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  • 8
    Electronic Resource
    Electronic Resource
    Neurons of the A1/A2 region in the guinea pig medulla oblongata containing glucagon, glicentin, and dopamin-β-hydroxylase immunoreactivity (1984)
    Springer
    Anatomy and embryology 170 (1984), S. 239-245 
    Details
    ISSN: 1432-0568
    Keywords: Glucagon ; Glicentin ; Dopamine-beta-hydroxylase ; Medulla oblongata ; A1/A2 Region ; Gumea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glucagon- (GLU-IR), glicentin- (GLI-IR) and dopamine-beta-hydroxylase (DBH-IR) immunoreactive neurons were mapped in the medulla oblongata of colchicine pretreated guinea pigs. Numerous GLU-IR and GLI-IR perikarya are located in the area of the nucleus ambiguus, in the adjacent formatio reticularis, and less frequently in the nucleus reticularis lateralis, the nuclei raphe obscurus and commissuralis and the caudal part of the nucleus solitarius. In these nuclei, the coexistence of glicentin and glucagon within the same perikarya is demonstrated. DBH-IR is also found in neurons of the nuclei commissuralis, solitarius and reticularis lateralis (A1/A2 system of Dahlström and Fuxe 1964, 1965). However, a coexistence of GLU/GLI-IR and DBH-IR within the same neuron is not observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318727
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  • 9
    Electronic Resource
    Electronic Resource
    On the developing rat placenta (1980)
    Springer
    Anatomy and embryology 159 (1980), S. 289-305 
    Details
    ISSN: 1432-0568
    Keywords: Placenta (rat) ; Development ; Intercellular junctions ; Ultrastructure ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The differentiation of chorionic layers II and III and alterations of intercellular junctions within the developing placental labyrinth were investigated in rats. Between the 14th and 16th day of gestation, the trabecular structures of the labyrinth alter and increasing numbers of primary, secondary, and tertiary lamellae develop. Trophoblastic layer I remains multicellular. Layer III rearranges and cytoplasmic fusions result in a continuous cytoplasmic barrier intervening between the already syncytial trophoblastic layer II and fetal capillaries. Simultaneously, most of the “undifferentiated” cells within the labyrinth disappear. Thin sectioning anf freeze-fracturing reveal multiple images of intercellular junctions, particularly gap and tight junctions in the cellular and syncytial parts of layers II and III. Continuous and regularly arranged tight junctions occur as well as fragmented structures which are spaced irregularly. Gap junctions are occasionally found between the juxtasinusoidal regions of layers II and III on the 14th day. More often they occur within restricted areas near the center of the trabeculae, integrated within extensive tight junctional strands. Gap junctions increase in later stages of pregnancy and eventually become distributed between the interfaces of layers II and III in the primary lamellae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317652
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  • 10
    Electronic Resource
    Electronic Resource
    Die Anordnung der Außenfibrillen bei Treponema pallidum (Stamm Nichols) (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 636-636 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The outer fibrils of treponema pallidum (tribe Nichols) form two bundles twisting around the entire length of treponema and crossing each other in regular distances.
    Notes: Zusammenfassung Die Außenfibrillen von Treponema pallidum (Stamm Nichols) bilden zwei gegenläufige Spiralbänder, die sich über den ganzen Zelleib des Erregers erstrecken und sich in regelmäßigen Abständen kreuzen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485401
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