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  • 1
    Electronic Resource
    Electronic Resource
    Convergence of cortico- and cuneopontine projections onto components of the pontocerebellar system in the rat: an anatomical and electrophysiological study (1988)
    Springer
    Experimental brain research 71 (1988), S. 541-556 
    Details
    ISSN: 1432-1106
    Keywords: Cerebral cortex ; Basilar pontine nuclei ; Dorsal column nuclei ; Cerebellum ; Convergence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous studies in the rat have demonstrated that corresponding peripheral tactile and somatosensory cortical inputs converge within the granule cell layer of various cerebellar lobules and further that descending corticopontine projections from the forelimb sensory cortex (FLSCx) partially overlap with the projection zones of ascending basilar pontine afferents from nucleus cuneatus (NC). The present study employed anatomical and electrophysiological procedures to determine whether cortical and dorsal column nuclear afferent projections converge on pontine neurons that, in turn, provide mossy fiber input to the granule cell layer of the paramedian lobule (PML), i. e., that portion of the rodent cerebellum shown to receive forelimb peripheral inputs. The combination of the orthograde and retrograde axonal transport of horseradish peroxidase (HRP) conjugated to wheat germ agglutinin (WGA) was used light microscopically to demonstrate that orthogradely labeled projections from injections of the FLSCx and NC converged with ponto-paramedian projection neurons that were retrogradely labeled from injections of the PML. These studies were also repeated in conjunction with ablations of either the FLSCx or NC which resulted in the ultrastructural identification of degenerating, as well as WGA-HRP labeled axonal boutons of these pontine afferent projections thus confirming that such projections actually formed synaptic contacts with the retrogradely labeled pontoparamedian projection neurons. Single unit recording analyses of neurons in the ventromedial region of the basilar pons following combined electrical stimulation of various regions of the sensorimotor cortex and the contralateral body surface indicated that approximately 40% of all cells recorded responded to electrical stimulation of corresponding regions of the cortex and periphery, particularly the FLSCx and the forepaw. Natural cutaneous stimuli applied to the forepaw that also elicited responses in these same groups of basilar pontine neurons and were associated with relatively small receptive fields. Taken together, these observations indicate that the previously observed convergence of peripheral and somatosensory cortical inputs within the granule cell layer of the cerebellar cortex may be at least partially organized at the level of the basilar pons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00248746
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The auditory corticopontocerebellar projection in the rat: inputs to the paraflocculus and midvermis. An anatomical and physiological study (1985)
    Springer
    Experimental brain research 59 (1985), S. 36-49 
    Details
    ISSN: 1432-1106
    Keywords: Auditory cortices ; Paraflocculus ; Cerebellum ; Corticocerebellar pathways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study investigated afferent projections to the cerebellum, in particular those from the auditory cerebral cortex. The parafloccular lobule of the rat cerebellum is shown to be a primary target for the auditory cortical information with the midvermal region being a receiving area from the inferior colliculus. The method of anterograde transport of tritiated amino acids was employed to determine projections of the auditory cortex to the pons. Autoradiography showed that the site of termination of efferents from the auditory cortex corresponds to the location of neurons that project to the paraflocculus. Histogram analysis of neuronal activity in halothane anesthetized rats was employed to determine the response characteristics of neurons in paraflocculus and midvermis following cortical and tectal electrical stimulation. In addition, unit recordings of parafloccular neurons in immobilized, locally anesthetized animals demonstrated general characteristics of the responses of these neurons to auditory field stimulation. Electrical stimulation of the auditory cortex evoked mixed, excitatory-inhibitory and pure inhibitory mossy fiber responses in 33% of neurons in the paraflocculus, with no responses evident in the midvermis. Following inferior collicular stimulation, 12.6% of the neurons in the midvermis elicited a response. Recordings from parafloccular neurons in unanesthetized, immobilized rats showed evidence for excitatory and inhibitory mossy fiber responses, following auditory field stimulation. This spectrum of basic studies establishes the existence of a pathway in which the paraflocculus is revealed as an integrating target for cortical auditory information.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237663
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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