ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The title compund, 1a, has been synthesised in racemic form from ethyl (E)-4-chloro-3-ethoxybut-2-enoate in 43% overall yield in five steps. Several routes to the final product are described, but the most efficient involves hydrogenation of a C(5)-unsubstituted tetramic acid 5b. The instability of this class of compounds required the use of a catalyst which could operate under very acidic aqueous conditions, a role that was successfully filled by a 5% Ru/C catalyst.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19920750323
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