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  • 1
    Electronic Resource
    Electronic Resource
    Myelin lipids: A phylogenetic study (1986)
    Springer
    Neurochemical research 11 (1986), S. 1261-1272 
    Details
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The lipid composition of CNS and PNS myelin was studied in rat,Xenopus, trout andTorpedo. The main difference lay in the proportion of cerebrosides, which decreased in the sequence rat 〉 Xenopus 〉 Torpedo 〉 trout. In additionTorpedo CNS and PNS myelins were extremely rich in sulfatides. In some respects,Torpedo appeared closer to tetrapods than trout. Otherwise the proportion of the different lipid classes did not reveal any clear evolutionary trends. The presence of hydroxylated galactolipids in CNS myelin was investigated in several additional species. Considerable amounts were found inTorpedo, Polypterus, Protopterus, lizard, and chicken, with the highest values in rat and anurans. Only very small amounts of hydroxylated cerebrosides were detected in trout and in axolotl, while newt had none. This parameter appears therefore of doubtful usefulness for phylogenetic studies. In contrast to myelin proteins, myelin lipids are of limited value for establishing phylogenetic relationship among vertebrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00966121
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vivo labeling of myelin lipids and proteolipid protein with [3H]myristate, [14C]linoleate, and [14C]linolenate (1989)
    Springer
    Neurochemical research 14 (1989), S. 91-96 
    Details
    ISSN: 1573-6903
    Keywords: Myelin lipids ; proteolipid protein ; myristic acid ; linoleic acid ; lmolenic acid ; myelin basic protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the incorporation of essential fatty acids into myelin components, 24-day-old rabbits were injected intracerebrally with [14C]linoleate, [14C]linolenate, or [3H]Myristate for comparison. Animals were killed 22 hr later and myelin was isolated. [3H]myristate labeled all myelin lipids including monogalactosyl diglyceride, with the exception of sulfatides. With14C-essential fatty acids, only glycerophospholipids were efficiently labeled and their specific activities were in the following decreasing orders: PC〉PI〉PE〉PS with [14C]linoleate, and PE〉PC〉PI=PS with [14C]linolenate. Among myelin proteins, PLP and DM-20 were labeled with all 3 precursors. PLP was purified from myelin labeled with14C-essential fatty acids. The label was then cleaved from the protein by alkaline methanolysis and was identified as a dienoic ([14C]linoleate) or a tetraenoic ([14C]linolenate) fatty acid. MBP was not labeled with [3H]myristate, but was slightly labeled with both14C-essential fatty acids. The signification of the latter result is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00969764
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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