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  • 1
    Electronic Resource
    Electronic Resource
    A COMPARISON OF SYNDROMES DERIVED FROM THE CHILD BEHAVIOR CHECKLIST FOR AMERICAN AND DUTCH BOYS AGED 6–11 AND 12–16 (1987)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of child psychology and psychiatry 28 (1987), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Abstract— Child Behavior Checklists completed by parents of 1863 clinically referred American and Dutch boys aged 6–11 and 12–16 were subjected to principal components analyses with varimax rotations. For each age group, the construct validity of seven empirically derived syndromes was supported by cross-national correlations ranging from 0.80 to 0.98. These syndromes were designated as Aggressive, Delinquent, Depressed (ages 6–11 only). Hyperactive, Schizoid (ages 12–16 only). Somatic Complaints, Uncommunicative, and Withdrawal (Social Withdrawal for ages 6–11; Hostile Withdrawal for ages 12–16). Cross-national similarities in the distribution of scores for normative samples supported the use of the same syndrome scales by clinicians and researchers in the two countries. The cross-national construct validity of Obsessive-Compulsive and Immature syndromes did not receive adequate support.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-7610.1987.tb01765.x
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between perfusion pressure and renin release in the isolated rat kidney (1975)
    Springer
    Pflügers Archiv 360 (1975), S. 255-266 
    Details
    ISSN: 1432-2013
    Keywords: Renal Hemodynamics ; Renal Autoregulation ; Microspheres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isolated rat kidneys were perfused with either a modified Krebs-Henseleit solution containing a gelatine preparation (Haemaccel, 35 g/l) or with a suspension of washed bovine red blood cells (RBC). When perfusion pressure (PP) was varied repeatedly in the range between 30 and 210 mm Hg autoregulation of renal plasma flow (RPF) was almost complete in RBC perfused kindneys. Changes of PP by steps of 20 mm Hg at intervals of 5 min resulted in an incomplete autoregulation of RPF and glomerular filtration rate (GFR). Renin release (RR) was inversely related to PP in the range between 50 and 150 mm Hg, while perfusion at a pressure below or above that range had no further effect on RR. The most marked increase in RR was obtained, when PP was reduced from 90 to 70 mm Hg. After reduction of PP, an increase in RR was measurable within 1 min, and a maximum was reached after 5 min. In kidneys perfused with a cell-free medium at a PP of 45 mm Hg for up to 30 min, RR remained elevated for the entire period of pressure reduction. Injection of microspheres into the renal artery resulted in a prompt decrease of RPF, GFR and urinary sodium excretion, but the values returned towards control levels within 15 min; RR increased only transiently after a short initial fall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583720
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  • 3
    Electronic Resource
    Electronic Resource
    Mode of action of sodium nitroprusside on vascular smooth muscle (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 288 (1975), S. 381-402 
    Details
    ISSN: 1432-1912
    Keywords: Vasodilator Drugs ; Antihypertensive Drugs ; Excitation-contraction Coupling ; 45Calcium Uptake ; Cyclic AMP ; Lanthanum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Sodium nitroprusside is a potent relaxant of smooth muscles with a predominantly tonic response, e.g. rat aorta contracted by noradrenaline angiotensin II, Phe2-Lys8-vasopressin, BaCl2, or KCl, and guinea-pig tracheal smooth muscle contracted by carbachol. 2. Smooth muscle preparations from the splanchnic region and with varying degrees of phasic contractility are less sensitive and develop tachyphylaxis (portal vein, duodenum of the rat) or are unresponsive to sodium nitroprusside (vas deferens, uterus of the rat). 3. Cardiac auricles of the guinea pig are not affected by sodium nitroprusside in either frequency or amplitude of spontaneous contractions. 4. Sodium nitroprusside causes a parallel shift of the dose-response curve of rat aorta to noradrenaline to the right and reduces the maximum response. 5. The drug has no blocking or stimulant effect on α-or β-adrenoceptors, respectively. 6. Sodium nitroprusside inhibits the contractile response of calcium-depleted depolarized rat aorta to extra-cellular calcium. Like verapamil, it inhibits the increment in 45calcium uptake of rabbit aorta elicited by K+. Sodium nitroprusside significantly reduces 45calcium binding by microsomes prepared from rabbit aorta. 7. Rabbit aorta was incubated with lanthanum chloride to prevent calcium influx; sodium nitroprusside reduced the maintained rapid contraction phase in response to noradrenaline which is believed to be based on the intracellular activation of calcium. 8. In rat aorta, cellular cAMP and ATP levels were not found to be affected by the drug. 9. Rabbit aorta, “skinned” by glycerination, is unresponsive to sodium nitroprusside. 10. It is concluded that sodium nitroprusside acts on excitation-contraction coupling predominantly in tonic smooth muscle by interfering with both the influx and the intracellular activation of calcium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501284
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    Paper (German National Licenses)
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