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  • 1
    Electronic Resource
    Electronic Resource
    Sensitivity to nitrate and other oxyanions further distinguishes the vanadate-sensitive osteoclast proton pump from other vacuolar hydrogen ion-ATPases (1993)
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 2808-2812 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00062a011
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  • 2
    Electronic Resource
    Electronic Resource
    A quantitative study of bone remodeling during experimental periodontal disease in the golden hamster (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 13 (1978), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to determine whether periodontal disease in the golden hamster, induced by a six-month feeding of Keyes 2000 hyperglucidic diet, resulted in altered bone remodeling activity. The results show a significant increase in Howship's lacunae without changes in the extent of resorbing surface along the alveolar walls; this increase is associated with a significant decrease in the extent of bone formation surface. The same pattern is observed along the endosteum in the septa but is associated with a significant increase in the extent of actively resorbing surface. These results therefore indicate that there is a significant decrease in bone formation associated with the previously oberved increase in bone resorption during experimental periodontal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1978.tb00185.x
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  • 3
    Electronic Resource
    Electronic Resource
    A quantitative study of osteoclastic bone resorption during experimental periodontal disease in the golden hamster (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 12 (1977), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to measure the osteoclastic resorption of alveolar bone during an experimental periodontal disease. Twenty golden hamsters were used: 10 animals were fed a normal diet and served as controls and 10 animals were fed the Keyes hyperglucidic diet during 6 months to induce periodontal disease. The results show that the different surfaces of alveolar bone do not react in the same proportion: the number of osteoclasts is greatly and significantly increased (p 〈 0.001) along the periosteum, significantly increased (p 〈 0.01) along the endosteum, and not modified along the alveolar wall.The number of osteoclasts along the alveolar wall is negatively correlated with the number of osteoclasts along the endosteum and the periosteum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1977.tb01529.x
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  • 4
    Electronic Resource
    Electronic Resource
    The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Immunological reviews 208 (2005), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary:  The osteoclast resorbs mineralized bone during bone development, homeostasis, and repair. The deletion of the gene encoding the nonreceptor tyrosine kinase c-Src produces an osteopetrotic skeletal phenotype that is the consequence of the inability of the mature osteoclast to efficiently resorb bone. Src–/– osteoclasts exhibit reduced motility and abnormal organization of the apical secretory domain (the ruffled border) and attachment-related cytoskeletal elements that are necessary for bone resorption. A key function of Src in osteoclasts is to promote the rapid assembly and disassembly of the podosomes, the specialized integrin-based attachment structures of osteoclasts and other highly motile cells. Once recruited to the activated integrins, especially αvβ3, by the adhesion tyrosine kinase Pyk2, Src binds and phosphorylates Cbl and Cbl-b, homologous multisite adapter proteins with ubiquitin ligase activity. The Cbl proteins in turn recruit and activate additional signaling effectors, including phosphatidylinositol 3-kinase and dynamin, which play key roles in the development of cell polarity and the regulation of cell attachment and motility. In addition, Src and the Cbl proteins contribute to signaling cascades that are activated by several important receptors, including receptor activator of nuclear factor κB and the macrophage colony-stimulating factor receptor, and also downregulate the signaling from many of these receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-2896.2005.00335.x
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  • 5
    Electronic Resource
    Electronic Resource
    Arming the osteoclast (2004)
    [s.l.] : Nature Publishing Group
    Nature medicine 10 (2004), S. 458-460 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Inflammation and bone resorption often go hand in hand, a fact evident in conditions such as joint destruction in rheumatoid arthritis or periodontal disease. Osteoclasts, the bone-resorbing cells of the organism, also share several features with macrophages and dendritic cells. Osteoclasts are ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0504-458
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of parathyroid hormone on the osteoclastic pool, bone resorption and formation in rat alveolar bone (1978)
    Springer
    Calcified tissue international 26 (1978), S. 23-28 
    Details
    ISSN: 1432-0827
    Keywords: Parathyroidectomy ; Parathyroid hormone ; Osteoclasts ; Bone remodeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The osteoclast number and its relation to parathyroid hormone have been studied in rat alveolar bone by quantitative histology and fluorescent labeling. The osteoclast number decreases 60 h after parathyroidectomy and remains constant for the next 132 h. Parathyroid hormone administration to parathyroidectomized animals 96 h after the operation induces an increase in osteoclast number within 12 h to some-what above those of control animals. The elevated osteoclast counts remain constant for 60 h then rapidly fall over the next 24 h to the level seen in untreated parathyroidectomized animals. As determined by fluorescent labeling, normal alveolar bone resorption and formation were disturbed by parathyroidectomy, such that significant bone formation occurred for only 6 days after surgery, after which a quiescent state followed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013229
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  • 7
    Electronic Resource
    Electronic Resource
    c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption (1996)
    [s.l.] : Nature Publishing Group
    Nature 383 (1996), S. 528-531 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The product of the proto-oncogene c-Cbl is a protein of relative molecular mass 120K that is tyrosine-phosphorylated in response to the activation of various signalling pathways and in v-Src- FIG. 1 c-Cbl requires c-Src to be phosphorylated in osteoclast-like cells, a, c-Cbl, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/383528a0
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  • 8
    Electronic Resource
    Electronic Resource
    Spred is a Sprouty-related suppressor of Ras signalling (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 412 (2001), S. 647-651 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cellular proliferation, and differentiation of cells in response to extracellular signals, are controlled by the signal transduction pathway of Ras, Raf and MAP (mitogen-activated protein) kinase. The mechanisms that regulate this pathway are not well known. Here we describe two structurally ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35088082
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  • 9
    Electronic Resource
    Electronic Resource
    An electron-microscopic study of the bone-remodeling sequence in the rat (1982)
    Springer
    Cell & tissue research 225 (1982), S. 283-292 
    Details
    ISSN: 1432-0878
    Keywords: Bone remodeling ; Osteoclast ; Osteoblast ; Mononuclear-phagocytes ; Osteoclast precursors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A detailed chronological electron-microscopic study of the bone remodeling sequence has been performed in the rat based on a previously described model (Tran Van et al. 1982) in which the remodeling activity is synchronized. This allowed the observation of the cellular and extracellular events during the bone remodeling process, including the activation of the sequential process and the reversal phase, intermediate between osteoclastic resorption and osteoblastic formation. Most important is the fact that throughout the whole process cells with the morphological characteristics of mononuclear phagocytes have been observed in proximity or in contact with the bone surface and/or the various bone cells. Coated pits (receptor-mediated endocytosis) are frequently observed in close apposition to bone spicules and gap junctions are frequent between the cells. These observations suggest that, besides being likely candidates as osteoclast precursors, mononuclear phagocytes may play an important role in bone remodeling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214682
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  • 10
    Electronic Resource
    Electronic Resource
    Cellular kinetics of the bone remodeling sequence in the rat (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 202 (1982), S. 445-451 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The kinetics of the bone remodeling sequence in the rat has been studied using a system in which well-synchronized remodeling units were induced along the periosteum of rat mandibles. Remodeling of the periosteal surface of the mandibles was induced according to Tran Van (1979) by extraction of the opposing row of teeth; namely, the right maxillary molars were extracted under light ether anesthesia, therefore allowing the right mandibular molars to egress; this, in turn, induced a wave of remodeling activity on the buccal side of the periosteal surface of the alveolar bone. The quantification of the different cellular activities involved in bone remodeling has been performed up to 16 days after induction. This allowed us to demonstrate the sequential activity of the different cell types involved in bone remodeling, to study the cellular kinetics of this sequence of events, and to directly measure the duration of each phase of the bone remodeling sequence. A single wave of osteoclasts appeared 3 days after induction, reached a peak at 4-5 days, and then decreased sharply. This was followed by a single wave of mononuclear cells (Baron et al., 1980) within remodeling sites during the reversal phase; they appeared 4 days after induction, reached a peak by day 7, and then decreased sharply. This reversal activity was then followed by osteoblasts forming new bone on top of a reversal cement line in the remodeling sites, starting 6 days after induction and increasing until the end of the experiment. In addition, the synchronization of the system used in this study allowed direct measurement of the duration of the successive steps of the remodeling sequence. The directly measured values have then been compared to previous data calculated from other systems.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092020403
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