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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Immunological reviews 208 (2005), S. 0 
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary:  Osteoclasts are primary cells for physiological and pathological bone resorption, and receptor activator of nuclear factor-κB ligand (RANKL) is critically involved in the differentiation, activation, and survival of these cells. Recently, therapeutics for pathological bone destruction targeting RANKL pathways has attracted a great deal of attention. Herein, we review the recent advances in the research on osteoclast biology and discuss the advantages and disadvantages of anti-RANKL therapies.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The product of the proto-oncogene c-Cbl is a protein of relative molecular mass 120K that is tyrosine-phosphorylated in response to the activation of various signalling pathways and in v-Src- FIG. 1 c-Cbl requires c-Src to be phosphorylated in osteoclast-like cells, a, c-Cbl, ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 15 (1979), S. R203 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 15 (1979), S. R213 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 16 (1980), S. R63 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 15 (1979), S. R49 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 16 (1980), S. R251 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Résumé On a procédé à une analyse critique de la relation entre la vitesse de relaxation de l'énergie G et les facteurs d'intensité de contrainte dans le cas de l'extension d'une fissure non coplanaire sous des modes de chargement I, II et III. En développant une méthode différente de l'application de l'équation de Bueckner, on a obtenu une équation pour G fonction des facteurs d'intensité de contrainte à l'extrémité d'un ressaut infinitésimal tel que formé par l'extension d'une fissure non coplanaire. Parmi les trois équations de G existantes qui se trouvent être mutuellement contradictoires l'équation de Nuismer et l'équation de Wang ne sont pas en accord avec les résultats obtenus dans le mémoire. Dans le cas où un mode de sollicitation III n'est pas pris en considération, l'équation de Hussain et al. est en accord avec les résultats obtenus bien que leur analyse semble contenir des points discutables.
    Notes: Abstract A critical analysis was made on the relationship between the energy release rate G and the stress intensity factors for non-coplaner crack extension under combined Mode I, II and III loading. Developing a method different from the application of Bueckner's equation, the equation of G was derived as % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGak0Jf9crFfpeea0xh9v8qiW7rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGaam4raiabg2% da9iaacUfacaGGOaGaeuOUdSMaey4kaSIaaGymaiaacMcacaGGVaGa% aGioaiabfY7aTjaac2facaGGOaGabm4sayaaiaWaa0baaSqaaiaabM% eacaWGIbaabaGaaGOmaaaakiabgUcaRiqadUeagaacamaaDaaaleaa% caqGjbGaaeysaiaadkgaaeaacaaIYaaaaOGaaiykaiabgUcaRiaacI% cacaaIXaGaai4laiaaikdacqqH8oqBcaGGPaGaey4kaSIabm4sayaa% iaWaa0baaSqaaiaabMeacaqGjbGaaeysaiaadkgaaeaacaaIYaaaaa% aa!5988!\[G = [(\kappa + 1)/8\mu ](\tilde K_{{\text{I}}b}^2 + \tilde K_{{\text{II}}b}^2 ) + (1/2\mu ) + \tilde K_{{\text{III}}b}^2 \], where % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGak0dh9WrFfpC0xh9vqqj-hEeeu0xXdbba9frFj0-OqFf% ea0dXdd9vqaq-JfrVkFHe9pgea0dXdar-Jb9hs0dXdbPYxe9vr0-vr% 0-vqpWqaaeaabaGaciaacaqabeaadaqaaqaaaOqaaGqaciqa-Teaga% acamaaBaaaleaaieaacaGFjbGaa4NyaaqabaGccaqGGaGab83sayaa% iaWaaSbaaSqaaiaa+LeacaGFjbGaa4NyaiaabccaaeqaaKaaajaa+f% gacaGFUbGaa4hzaOGaa4hiaiqa-TeagaacamaaBaaaleaacaGFjbGa% a4xsaiaa+LeacaGFIbGaaeiiaaqabaaaaa!477C!\[\tilde K_{Ib} {\text{ }}\tilde K_{IIb{\text{ }}} and \tilde K_{IIIb{\text{ }}} \] are the stress intensity factors at the tip of an infinitesimal kink as formed by non-coplaner crack extension. Among the three existing equations of G which are mutually contradictory, Nuismer's equation and Wang's equation disagree with the present result. In the case where Mode III loading is not involved, Hussain et al's equation agrees with the present result, although their analysis seems to contain questionable points.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 15 (1979), S. R183 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0730-2312
    Keywords: Key words ; osteoclast ; focal adhesion kinase ; tyrosine kinase ; tyrosine phosphorylation ; podosome ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Involvement of tyrosine phosphorylation in osteoclastic bone resorption was examined using osteoclast-like multinucleated cells prepared from co-cultures of mouse osteoblastic cells and bone marrow cells in the presence of 1α,25-dihydroxyvitamin D3. When osteoclast-like cells were plated on culture dishes in the presence of 10% fetal bovine serum, they were sharply stained in their peripheral region by anti-phosphotyrosine antibody. Western blot analysis revealed that 115-to 130-kD proteins were tyrosine-phosphorylated in osteoclast-like cells. Using immunoprecipitation and immunoblotting, one of the proteins with 115-130 kD was identified as focal adhesion kinase (p125FAK), a tyrosine kinase, which is localized in focal adhesions. Immunostaining with anti-p 125FAK antibody revealed that p125FAK was mainly localized at the periphery of osteoclast-like cells. Herbimycin A, a tyrosine kinase inhibitor, not only suppressed tyrosine phosphorylation of p125FAK but also changed the intracellular localization of p125FAK and disrupted a ringed structure of F-actin-containing podosomes in osteoclast-like cells. Antisense oligodeoxynucleotides to p125FAK inhibited dentine resorption by osteoclast-like cells, whereas sense oligodeoxynucleotides did not. These results suggest that p125FAK is involved in osteoclastic bone resorption and that tyrosine phosphorylation of p125FAK is critical for regulating osteoclast function.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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