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  • 1
    Electronic Resource
    Electronic Resource
    The oncogenic 30 and 69 bp deletion variants of the EBV LMP-1 gene are common in HIV-negative lymphoproliferations, both malignant and benign (1999)
    Springer
    Annals of oncology 10 (1999), S. 467-469 
    Details
    ISSN: 1569-8041
    Keywords: Epstein–Barr virus ; LMP-1 ; lymphoid disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In vitro studies have shown that the 30 and 69 base pair (bp) deletion variants of the latent membrane protein (LMP)-1 gene of the Epstein–Barr virus (EBV) have a higher transforming capacity than the wild-type variant. In recent years these studies have triggered an in vivo search for such potentially oncogenic variants in lymphoid tissues. Patients and methods: We used polymerase chain reaction (PCR) to investigate the prevalence of LMP-1 gene variants in EBV-positive lymph nodes from 60 HIV-negative Italian patients with benign and malignant lymphoid disorders. Results: The 30 bp variant was detected in 10 of 39 (25.6%) malignant lymphomas but also in 4 of 13 (30%) reactive lymphadenitis with follicular hyperplasia. Of note is the fact that the 69 bp variant was detected in three cases of malignant lymphoproliferation but also in two cases of localized Castleman's disease of hyalin vascular type. Conclusions: The molecular detection of the oncogenic variants of the LMP-1 gene in a lymph node biopsy as an indicator of the aggressiveness of the EBV-associated lymphoproliferative disease must be considered with caution. The relatively high frequency of the 69 bp variant in our series compared with that reported in the literature probably reflects a different incidence of LMP-1 variants in healthy populations from different geographical areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008381006612
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  • 2
    Electronic Resource
    Electronic Resource
    Human herpes virus 6 and human herpes virus 8 DNA sequences in brains of multiple sclerosis patients, normal adults and children (1997)
    Springer
    Journal of neurology 244 (1997), S. 450-454 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Human herpesvirus 6 ; Human ; herpesvirus 8 ; Polymerase chain ; reaction ; Brain DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to determine whether the newly discovered human herpesviruses (HHVs) are involved in multiple sclerosis (MS), we investigated by polymerase chain reaction the presence of specific deoxyribonucleic acid (DNA) sequences belonging to human herpesvirus 6 (HHV-6) and to human herpesvirus 8 (HHV-8), in the peripheral blood mononuclear cells (PBMCs), and in the brain and spinal cord plaques from MS patients. Normal adult and stillborn children’s brains were investigated as controls. PBMCs from 56 MS patients contained HHV-6 DNA in only 3 cases and in none were there HHV-8 sequences. The cerebral DNA from 5 MS patients was positive for HHV-8 and not for HHV-6 sequences, while the nervous tissue of one patient who died with neuromyelitis optica was positive for HHV-6 and negative for HHV-8. The brains of 4/8 adult controls were positive for HHV-6, as were 3/8 for HHV-8; none of the 7 stillborn children’s cerebral tissue contained HHV-6 sequences, while 2 contained HHV-8 DNA. Although these data do not support a hypothesis that there is a role for these two HHVs in the pathogenesis of MS, nevertheless it may be suggested that (1) the two viruses possess strong neurotropism and the central nervous system seems to be a reservoir for them (2) HHV-6 infection is probably not transmitted maternally, but is acquired later in infancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050121
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Clinico-pathological characterization of hepatitis C virus-related B-cell non-Hodgkin's lymphomas without symptomatic cryoglobulinemia (1998)
    Springer
    Annals of oncology 9 (1998), S. 495-498 
    Details
    ISSN: 1569-8041
    Keywords: B-cell non-Hodgkin‘s lymphoma ; HCV ; mixed cryoglobulinemia type II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Epidemiological evidence has suggested an association betweenhepatitis C virus (HCV) infection and B-cell lymphoproliferation. We studiedthe prevalence of HCV infection in a series of de novo B-cell non-Hodgkin‘slymphoma (B-NHL) cases and correlated virological findings withclinico-histological features. Patients and methods: One hundred fifty-seven patients with de novo B-NHLwere included in the study. Their serum was examined by ELISA and RIBA forthe presence of anti-HCV antibodies, and either the peripheral bloodmononuclear cells or the pathology tissues of all of the patients wereexamined by reverse transcriptase polymerase chain reaction for the presenceof HCV RNA sequences. Results: HCV infection occurred in 22.3% of B-NHL patients and wasdocumented before the diagnosis in about half of the positive cases. Ofinterest, HCV infection was more frequently found in follicular center,marginal zone and diffuse large-cell lymphoma types, but was not associatedwith symptomatic cryoglobulinemia. The median survival time was 48 months inHCV-positive and 52 months in HCV-negative B-NHL patients. Conclusions: Our findings strengthen the pathogenetic link between HCV andB-NHL and show that HCV infection may be associated with the malignantproliferation of defined B-cell subsets other than the immunoglobulin MkB-cell subset involved in the pathogenesis of mixed cryoglobulinemia type IIandassociated lymphoplasmacytoid lymphoma type. HCV-related liver disease did notaffect the survival of our B-NHL patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008255830453
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    Paper (German National Licenses)
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