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  • 1
    Electronic Resource
    Electronic Resource
    Long-Term Depression in Hippocampus (1996)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 19 (1996), S. 437-462 
    Details
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ne.19.030196.002253
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of intracortical infusion of 6-hydroxydopamine on the response of kitten visual cortex to monocular deprivation (1983)
    Springer
    Experimental brain research 51 (1983), S. 413-422 
    Details
    ISSN: 1432-1106
    Keywords: Visual cortex ; Plasticity ; Catecholamines ; 6-Hydroxydopamine ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 4 and 10 weeks of age 10 normally reared kittens were bilaterally implanted with osmotic minipumps. The visual cortex of one hemisphere was infused with 4 mM 6-hydroxydopamine while the other hemisphere received only a vehicle solution. The pumps delivered the solutions at 1 μl/h for one week concurrent with monocular deprivation. Subsequent electrophysiological recording was performed blind and revealed a marked effect of the 6-OHDA treatment: while most cells in the control hemisphere were primarily activated by stimulation of the non-deprived eye, cells in the 6-OHDA-treated hemisphere were significantly more binocular. High pressure liquid chromatography revealed that the loss of normal ocular dominance plasticity in 6-OHDA-infused hemispheres was always accompanied by at least a 50% decrease in cortical norepinephrine levels and a smaller decrease in dopamine levels. Furthermore, there appeared to be a positive correlation of the degree of ocular dominance shift and the relative amount of norepinephrine present. These results are consistent with the hypothesis that catecholamines, especially norepinephrine, are normally required for ocular dominance plasticity during the critical period in kittens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237878
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experience-dependent modifications of kitten striate cortex are not prevented by thalamic lesions that include the intralaminar nuclei (1988)
    Springer
    Experimental brain research 70 (1988), S. 627-631 
    Details
    ISSN: 1432-1106
    Keywords: Visual cortex ; Development ; Plasticity ; Intralaminar nuclei ; Kitten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been shown previously that surgical lesions of the antero-medial thalamus interfere with ocular dominance modifications that normally result from monocular deprivation in young kittens (Singer 1982). The aim of the present study was to determine whether this effect was due specifically to the destruction of the visual cortical projections of the anterior intralaminar nuclei. We report here that large excitotoxin lesions of the anterior dorsal thalamus have no effect on the cortical response to monocular deprivation. These data indicate that the intralaminar projection is not essential for ocular dominance plasticity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247611
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of age and visual experience on [3H] MK801 binding to NMDA receptors in the kitten visual cortex (1991)
    Springer
    Experimental brain research 85 (1991), S. 611-615 
    Details
    ISSN: 1432-1106
    Keywords: NMDA receptor ; [3H] MK801 ; Visual cortex ; Plasticity ; Kitten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have investigated the postnatal development of N-methyl-D-aspartate (NMDA) receptors in kitten neocortex by measuring the density of [3H] MK801 binding sites. NMDA receptor density in area 17 markedly increases between postnatal day 7 and 35, and then remains at a high level into adulthood. Similar temporal changes were observed in area 6. A brief period of binocular deprivation did not alter the density of [3H] MK801 binding sites in either brain region. However, dark rearing kittens from birth resulted in a significant decrease after 35 and 120 days in both area 17 and area 6. These results demonstrate that the density of NMDA receptors does not effectively predict the capacity for visual cortical plasticity in kitten neocortex. In addition, these results show that dark rearing produces significant effects in areas of the kitten neocortex not normally associated with visual function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231745
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The stability of 6-hydroxydopamine under minipump conditions (1984)
    Springer
    Experimental brain research 56 (1984), S. 183-186 
    Details
    ISSN: 1432-1106
    Keywords: 6-Hydroxydopamine ; Plasticity ; High performance liquid chromatography ; Kitten striate cortex ; Norepinephrine ; Osmotic minipumps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A number of investigators have recently used osmotic minipumps to continuously deliver the neurotoxin 6-hydroxydopamine (6-OHDA) to kitten cerebral cortex for periods up to 7 days. Because this compound is known to be particularly labile, we studied the stability of 6-OHDA stored under conditions similar to those found in an osmotic minipump. In 0.4% ascorbic acid, 4 mM 6-OHDA-HBr was found to be stable for at least one week as determined by (1) assay of the drug by high performance liquid chromatography and electrochemical detection and (2) test of the drug's ability to deplete mouse heart norepinephrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237455
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro (1990)
    Springer
    Experimental brain research 80 (1990), S. 252-259 
    Details
    ISSN: 1432-1106
    Keywords: Calcium uptake ; NMDA receptor ; Striate cortex ; Deprivation ; Kitten ; Synoptic plasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary As a functional measure of NMDA receptor effectiveness in kitten striate cortex, the uptake of 45Ca by visual cortical slices was measured after 2 minute bath applications of N-methyl-d-aspartate (NMDA). Significant Ca uptake occured in response to 12.5–100 μM NMDA in slices prepared from visual cortex of normal animals aged 28–48 days. Basal uptake (in the absence of NMDA) was increased and evoked uptake was decreased in visual cortical slices prepared from age-matched dark-reared animals. Four days of binocular deprivation in otherwise normally reared animals had no effect on basal uptake, but significantly lowered NMDAevoked Ca uptake at agonist concentrations greater than 25 μM. These data suggest that even brief manipulations of sensory experience are sufficient to alter visual cortical calcium regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228153
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    Paper (German National Licenses)
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