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  • 1
    ISSN: 1432-1041
    Keywords: Dopamine ; renal function ; renal blood flow ; glomerular filtration rate ; reserve capacity ; elderly ; low protein diet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The aims of this study were to determine the effects of dopamine and a low protein diet on glomerular filtration rate and effective renal plasma flow in the aged kidney. Effective renal plasma flow was measured using 125I-labelled hippuran and glomerular filtration rate using 51Cr-labelled EDTA. Low-dose continuous intravenous dopamine 3 μg·kg−1·min−1 in 10 healthy elderly volunteers caused a significant increase in effective renal plasma flow but not in the mean glomerular filtration rate when compared with baseline. However, glomerular filtration rate did increase substantially in 5 subjects (mean 14.4, SD 1.3). This implied that the elderly kidney was working maximally without reserve capacity in half the elderly. Since renal function is likely to be even more reduced in elderly patients with congestive cardiac failure, dopamine infusions may have little place in this condition in some older patients. A low protein diet (0.69 g·kg−1) in the same volunteers reduced glomerular filtration rate, suggesting that protein restriction may help to reduce the increased filtration rate in the remaining nephrons, thereby leading to structural and functional preservation in the aged kidney.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 18 (1983), S. 3337-3347 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Type I PAN-based carbon fibres have been stressed to failure in glycerol; this enables the fracture ends to be preserved intact for subsequent examination, first by scanning electron microscopy, then, after embedding and sectioning, by transmission electron microscopy. Internal flaws which did not initiate failure was seen to have walls containing crystallites arranged mainly parallel to the fibre axis. Internal and surface flaws which did initiate failure showed evidence of large misoriented crystallites in the walls of the flaws. It is the presence of misoriented crystallites rather than the flaw itself which determines whether or not tensile failure will occur. Our observations are entirely consistent with the Reynolds-Sharp mechanism of tensile failure in which the concentration of shear energy in a misoriented crystallite is not relieved by cracks parallel to the layer planes but by cracks at right angles. It is possible to predict that, in the absence of gross flaws, breaking strains of 1 to 1.3% should be possible in Type I PANbased carbon fibres, and greater than 2% in Type II carbon fibres.
    Type of Medium: Electronic Resource
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