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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To test the hypothesis that duodenal colonization represents the final crucial step in the development of Helicobacter pylori related duodenal ulcer.Methods : Patients with non-ulcer dyspepsia who had gastric colonization by H. pylori were included in the study. At baseline endoscopy, we evaluated the prevalence of duodenal colonization (culture, urease testing and histology), and cytotoxin-associated gene A status (polymerase chain reaction). No patients received eradication during 1 year follow-up. At this time, endoscopy was repeated and the incidence of duodenal ulcer was assessed.Results : Among 181 patients completing follow-up, 53 (29%) had duodenal colonization: 72% of them were cytotoxin-associated gene A positive, versus 37% patients without duodenal colonization (P 〈 0.001). Duodenal ulcer developed in 12 (22.6%) patients with duodenal colonization and in two (1.6%) without duodenal colonization (odds ratio for duodenal ulcer: 6.29, 95% confidence intervals 2.44–17.45). The incidence of duodenal ulcer was similar among cytotoxin-associated gene A positive and cytotoxin-associated gene A negative subjects with duodenal colonization: 21.05% versus 26.6%.Conclusions : The assessment of duodenal colonization by H. pylori in patients with non-ulcer dyspepsia is strongly predictive for the subsequent development of duodenal ulcer and may help to stratify patients at risk for this disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7284
    Keywords: Alcohol consumption ; Behaviour ; Knowledge ; Nurse ; Students
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A study was carried out on alcohol intake among the students of the Schools for Trained Nurses in the province of Bologna by means of an anonymous especially prepared questionnaire. The series consisted of 1077 subjects: 753 females and 324 males aged between 16 and 40. 68.2% of males and 56.8% of females drank wine, 1'81.3% of males and 61.8% of females drank beer and 65.3% of males and 46.2% of females drank spirits. While beer was the most popular drink, wine was on average drank in greater quantity. Alcohol intake was significantly related to sex (higher among males), area of origin (South) and cigarette smoking. The risk attributable to alcohol abuse are well known to almost all of the sample, above all those in the 2nd and 3rd years of their course. Nevertheless their alcohol consumption was not particularly different from that of students attending other High Schools. Regarding the sources of their information about the risks, the ‘mass media’ was more quoted by the oldest students while ‘family’ was given by the younger students; the Nursing School was more often mentioned by both sexes in the 2nd and 3rd year of course. No relation however was found between the students knowledge of risks and actual consumption.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To test whether Helicobacter pylori may contribute to the inflammatory response following myocardial infarction, the levels of IgG antibodies to Helicobacter pylori and some parameters of leukocyte activity were measured in 63 patients and 61 comparable controls. Helicobacter pylori-positive patients showed a significantly higher expression of the adhesion molecule LFA-1 on neutrophils than Helicobacter pylori-negative patients (433±29.0 vs. 398.8±38.9 mean fluorescence channels; P〈0.0001), whereas no significant difference for any parameters tested was found in control subjects. These data suggest a role of Helicobacter pylori in inducing a leukocyte response following myocardial infarction.
    Type of Medium: Electronic Resource
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