Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
FEMS microbiology letters
76 (1991), S. 0
ISSN:
1574-6968
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
A streptococcal cell surface antigen of Mr 185 000 (SAI/II) expressed by Streptococcus mutans has previously been well characterised. A T cell line specific for native SAI/II has been isolated from peripheral blood mononuclear cells (PBMC) of a naturally sensitised normal individual. This line has been maintained in culture for several months and was shown to be highly specific, not only for different preparations of native antigen but also for recombinant SAI/II protein. It did not respond to a homologous antigen SpaA (Mr 210 000), extracted from Strep sobrinus. The phenotype of the line was CD3+ CD4+ CD8− TcRαβ+. HLA typing and inhibition studies showed that the response was restricted by both DR and DP encoded class II.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1574-6968.1991.tb04212.x
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