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  • 1
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    Björkman, W.: Beiträge zur Geschichte der Staatskanzlei im islamischen Ägypten (Book Review) (1930)
    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 33 (1930) 46 
    Details
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Besprechungen
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4148-1930-033-00-000069
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  • 2
    Electronic Resource
    Electronic Resource
    A new approach to automatic photomultiplier stabilization for photon and scintillation counters
    Amsterdam : Elsevier
    The @International Journal Of Applied Radiation And Isotopes 31 (1980), S. 12 
    Details
    ISSN: 0020-708X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-708X(80)90176-3
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  • 3
    Electronic Resource
    Electronic Resource
    Transport and utilization of ferrioxamine-E-bound iron inErwinia herbicola (Pantoea agglomerans) (1991)
    Springer
    BioMetals 4 (1991), S. 181-185 
    Details
    ISSN: 1572-8773
    Keywords: Erwinia herbicola (Pantoea agglomerans) ; Ferrioxamine E ; In vivo M6ssbauer spectroscopy ; Iron metabolism ; Iron transport ; Siderophores
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary We have analyzed ferrioxamine-E-mediated iron uptake and metabolization inErwinia herbicola K4 (Pantoea agglomerans) by means of in vivo Mössbauer spectroscopy and radioactive labeling techniques. A comparison of cell spectra with the spectrum of ferrioxamine clearly demonstrates that ferrioxamine E is not accumulated in the cell, indicating a fast metal transfer. Only two major components of iron metabolism can be detected, a ferric and a ferrous species. At 30 min after uptake, 86% of the internalized metal corresponded to a ferrous ion compound and 14% to a ferric iron species. Metal transfer apparently involves a reductive process. With progressing growth, the oxidized species of the two major proteins becomes dominant. The two iron metabolites closely resemble species previously isolated fromEscherichia coli. These components of iron metabolism differ from bacterio-ferritin, cytochromes and most iron-sulfur proteins. All other iron-containing cellular components are at least one order of magnitude lower in concentration. We suggest that the ferrous and ferric iron species correspond to two different oxidation states of a low-molecular mass protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01141312
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  • 4
    Electronic Resource
    Electronic Resource
    Iron uptake and intracellular metal transfer in mycobacteria mediated by xenosiderophores (1997)
    Springer
    BioMetals 10 (1997), S. 193-203 
    Details
    ISSN: 1572-8773
    Keywords: EPR ; iron transport ; Mössbauer spectroscopy ; mycobacterium ; xenosiderophores
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Growth promotion was tested using M. smegmatis wild type strain, an exochelin-deficient mutant, and M. fortuitum employing a broad variety of xenosiderophores including hydroxamates, catecholates and a-hydroxy carboxylic acids. The experiments revealed that utilization of siderophore-bound iron is substrate specific suggesting high-affinity siderophore receptor and transport systems. Concentration-dependent uptake of a selected xenosiderophore (fericrocin) in M. smegmatis showed saturation kinetics and uptake was inhibited by respiratory poisons. In situ Mössbauer spectroscopy of ferricrocin uptake in M. smegmatis indicated rapid intracellular reductive removal of the metal excluding intracellular ferricrocin accumulation. The ultimate intracellular iron pool is represented by a compound (δ = 0.43 mm s, DE = 1.03 mm s) which has also been found in many other microorganisms and does not represent a bacterioferritin, cytochrome or iron-sulfur cluster. By contrast, iron uptake via citrate - a compound exhibiting a very low complex stability constant - involves ligand exchange with mycobactin. Mycobactin has merely a transient role. The ultimate storage compound is an E.coli-type bacterioferritin, in which over 90% of cellular iron is located.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018351728081
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  • 5
    Electronic Resource
    Electronic Resource
    Transport and utilization of rhizoferrin bound iron in Mycobacterium smegmatis (1999)
    Springer
    BioMetals 12 (1999), S. 315-321 
    Details
    ISSN: 1572-8773
    Keywords: EPR ; iron transport ; Mössbauer spectroscopy ; mycobacterium ; rhizoferrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Transport and metabolization of iron bound to the fungal siderophore rhizoferrin was analyzed by transport kinetics, Mössbauer and EPR spectroscopy. Saturation kinetics (v max=24.4 pmol/(mg min), K m=64.4μM) and energy dependence excluded diffusion and provided evidence for a rhizoferrin transport system in M. smegmatis. Based on the spectroscopic techniques indications for intracellular presence of the ferric rhizoferrin complex were found. This feature could be of practical importance in the search of novel drugs for the treatment of mycobacterial infections. EPR and Mössbauer spectroscopy revealed different ferritin mineral cores depending on the siderophore iron source. This finding was interpreted in terms of different protein shells, i.e. two types of ferritins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009274415607
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  • 6
    Electronic Resource
    Electronic Resource
    The interaction of Fe(III), adriamycin and daunomycin with nucleotides and DNA and their effects on cell growth of fibroblasts (NIH-3T3) (1996)
    Springer
    BioMetals 9 (1996), S. 121-130 
    Details
    ISSN: 1572-8773
    Keywords: iron ; anthracyclines ; adriamycin ; daunomycin ; acetohydroxamic acid ; ternary complexes ; Mössbauer spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The interactions of the iron complexes of the anthracycline antitumour drugs daunomycin (DN) and adriamycin (ADM) with the mononucleotide AMP, herring sperm DNA, plasmic pBR322 and immortalized 3T3 fibroblasts were studied. By means of Mössbauer spectroscopy it was demonstrated that DNA is a powerful ferric iron chelator as compared with AMP, which is not able to compete with DN or acetohydroxamic acid for ferric iron. The difference between AMP and DNA is postulated to be based on the chelate effect. The Mössbauer spectra of the ternary Fe-anthracycline-DNA systems differ from Fe-anthracycline binary complexes, indicating rearrangement reactions. Dialysis experiments clearly disclose the formation of a ternary Fe-ADM-pBR322 complex, the topology of which differs substantially from intercalating ADM. The effect of Fe-ADM complexes (3:1) on the growth of immortalized mouse embryonal fibroblasts (NIH-3T3) was studied in comparison with ADM alone. No significant difference on the inhibition of cell growth was noticed, suggesting comparable cytotoxicity for the compounds. In contrast to literature data, no evidence was found for DNA cleavage by ferric ADM at molar ratios as high as 1/100 (ADM/base pair), even if the ternary systems were prepared in the light and in the presence of reducing or oxidizing agents. Based on our observations it seems that the cytotoxicity of both ADM and Fe-ADM oligomer is not based primarily on intercalation or direct interaction with DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00144616
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  • 7
    Electronic Resource
    Electronic Resource
    Presence of classical multidrug resistance and P-glycoprotein expression in human neuroblastoma cells (1998)
    Springer
    Annals of oncology 9 (1998), S. 1009-1014 
    Details
    ISSN: 1569-8041
    Keywords: multidrug resistance ; neuroblastoma ; p-glycoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The role of P-glycoprotein (Pgp) associated multidrug resistance for neuroblastoma patients is controversial. Therefore we asked whether at all the typical functional features of the multidrug resistance phenotype could be found in neuroblastoma cells and studied the prognostic relevance of Pgp expression. Patients and methods: Tumor touch preparations and tumor cell infiltrated bone marrow smears of 62 neuroblastoma patients were investigated. The expression of Pgp was determined by a highly sensitive immunosandwich technique. Drug resistance studies were performed by exposing cells to Pgp-dependent cytostatic drugs in tissue cultures. Intracellular drug accumulation was examined by rhodamine-123 fluorescence microscopy. Results: Pgp expression was demonstrable for the SK-N-SH cell line, but not detectable in CHP-100 and ten other neuroblastoma cell lines by immunocytochemistry. In tissue cultures, SK-N-SH cells showed a relative resistance to vincristine and adriamycin (45.1 and 12.7-fold resp.) and reduced intracellular accumulation of rhodamine-123 which could be normalized by the Pgp blocker verapamil. Pgp expression was detected by immunocytochemistry in 14 out of 62 tumors (22.6%). No correlation was found to the stage of the disease (P = 0.33), histopathological grading (P = 0.82), N-myc oncoprotein expression (P = 0.76) or N-myc oncogene amplification (P = 0.20). Kaplan–Meier analysis of event free survival for stage 4 tumors revealed a weak trend of inferior survival for patients with Pgp positive tumors (log-rank analysis: P = 0.069). Conclusions: Though Pgp expression is detectable and functional in neuroblastoma cells, but its presence does not provide much information to the complex phenomenon of chemotherapy resistance in patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008476528846
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  • 8
    Electronic Resource
    Electronic Resource
    Ferricrocin functions as the main intracellular iron-storage compound in mycelia ofNeurospora crassa (1988)
    Springer
    BioMetals 1 (1988), S. 18-25 
    Details
    ISSN: 1572-8773
    Keywords: Siderophores ; Ferricrocin ; Iron storage ; Sporulation ; In vivo Mössbauer spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Neurospora crassa produces several structurally distinct siderophores: coprogen, ferricrocin, ferrichrome C and some minor unknown compounds. Under conditions of iron starvation, desferricoprogen is the major extracellular siderophore whereas desferriferricrocin and desferriferrichrome C are predominantly found intracellularly. Mössbauer spectroscopic analyses revealed that coprogen-bound iron is rapidly released after uptake in mycelia of the wild-typeN.crassa 74A. The major intracellular target of iron distribution is desferriferricrocin. No ferritin-like iron pools could be detected. Ferricrocin functions as the main intracellular iron-storage peptide in mycelia ofN. crassa. After uptake of ferricrocin in both the wild-typeN. crassa 74A and the siderophore-free mutantN. crassa arg-5 ota aga, surprisingly little metabolization (11%) could be observed. Since ferricrocin is the main iron-storage compound in spores ofN. crassa, we suggest that ferricrocin is stored in mycelia for inclusion into conidiospores.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01128013
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  • 9
    Electronic Resource
    Electronic Resource
    Infradiaphragmatic bronchogenic cyst with high CT numbers in a boy with primitive neuroectodermal tumor (1994)
    Springer
    Pediatric radiology 24 (1994), S. 504-505 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abdominal bronchogenic cysts are very rare with less than 20 published cases. We report the case of a retroperitoneal bronchogenic cyst in a 12-year-old boy, who initially presented with a primitive neuroectodermal tumor of the pelvis. Computed tomography (CT) showed a small, hyperdense nonenhancing mass adjacent to the right crus of the diaphragm. Follow-up CT after chemotherapy showed a decrease in CT attenuation of this mass, but a slight increase in size. At surgery the mass was loosely attached to the diaphragm and final pathology confirmed the diagnosis of a bronchogenic cyst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02015013
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  • 10
    Electronic Resource
    Electronic Resource
    MRI of the knee region in leukemic children (1990)
    Springer
    Pediatric radiology 20 (1990), S. 272-276 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Part II demonstrates the results of MRI follow up studies of 23 children with leukemia. Differentiation between leukemic cells and normal hematopoesis by MRI is impossible. The state of disease can only be determined together with bone marrow biopsy. Clinical remission precedes the normalization of bone marrow signal by weeks. In non-responders, however, cytological findings and MRI findings seem to correlate at the same time. During therapy, areas of osteonecrosis may develop. They do not necessarily contradict continuing complete remission. But this does not affect the prognosis and complete remission is still a possibility. Diagnosis of relapse by MRI is only possible in correlation with studies during the different states of disease especially at clinical remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02019665
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