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  • 1
    Electronic Resource
    Electronic Resource
    Inappropriate mucin production in gall bladder metaplasia and neoplasia–an immunohistological study (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 5 (1981), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study demonstrates the presence of three antigens in glandular metaplasia occurring in patients with cholecystitis and cholelithiasis: specifically carcinoembryonic antigen (CEA), large intestinal mucin antigen (LIMA) and small intestinal mucin antigen (SIMA). These antigens could not be detected in normal gall bladder mucosa or in squamous metaplasia of the gall bladder. The occurrence of the three intestine-associated antigens in three carcinomas was irregular. In one mucinous carcinoma, only SIMA could be demonstrated. In one adenocarcinoma, SIMA was present in small areas of mucinous change, whilst CEA was present in the nonmucinous malignant tissue. In a mixed mucinous and non-mucinous adenocarcinoma with widespread dissemination, the three antigens were present both in the primary tumour and the metastases. These observations suggest that all forms of glandular metaplasia of the gall bladder are intestinal in nature and at least a proportion of gall bladder carcinomas are of an intestinal type. Finally they provide further immunological evidence that glandular metaplasia of the gall bladder should be considered a pre-malignant condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1981.tb01788.x
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  • 2
    Electronic Resource
    Electronic Resource
    Differential Rejection of Neurones and Neuroglia in Canine Cardiac Allografts (1970)
    [s.l.] : Nature Publishing Group
    Nature 228 (1970), S. 69-71 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As part of a study of the effects of immunosuppressive agents on the survival of canine cardiac allografts, we have noted the presence of histologically normal neurones in ganglia in proximity to both the sino-atrial and atrio-ventricular nodes in transplanted hearts. We used the technique of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/228069a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Renal Transplantation in Cattle Twins (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 741-742 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The kidney, usually the left, was transplanted to the left side of the neck after perfusion with heparin and procaine containing cold (4 C) Hartmann solution. The vascular anastomoses were completed within 30 min and the ureter was anastomosed to the oesophagus. In each animal only one of its own ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215741a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Species Distribution of Gastrointestinal Antigens (1966)
    [s.l.] : Nature Publishing Group
    Nature 210 (1966), S. 960-962 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The investigation was conducted on separate tissue blocks from stomach, small intestine and large intestine taken usually within 1 h of death from a large variety of mammals, as listed in Table 1, and other vertebrate species. Blocks, snap frozen in liquid nitrogen-isopentane freezing mixture at ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/210960a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Inappropriate mucin production in endodermal carcinoma —One point of view (1983)
    Springer
    Surgery today 13 (1983), S. 317-323 
    Details
    ISSN: 1436-2813
    Keywords: inappropriate mucins ; oncofoetal antigens ; endodermal carcinomas ; immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mucosal lining cells in the gastrointestinal tract respond to a threatening situation by secreting mucins manufactured during foetal life and this secretion is considered to be an early manifestation of cytogenetic instability and which may be the first step in the process of malignant transformation. Using immunohistological techniques and specific antisera against SIMA (small intestinal mucin antigen), LIMA (large intestinal mucin antigen) and CEA (carcinoembryonic antigen) the presence of these mucin antigens was studied in resected specimens from colonic, gastric and gall bladder carcinomas as well as in mucinous tumours of the ovary. Inappropriate or oncofoetal mucins were present in the majority of endodermal carcinomas, in associated metaplastic epithelium and premalignant lesions such as polyps. These antigens were also demonstrated in normal histological epithelium at some distance from the tumour. These findings lead to a better understanding of the biological behaviour of preneoplastic lesions of endodermal tissues and will aid in developing sensitive diagnostic tests for the presence of these substances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469513
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  • 6
    Electronic Resource
    Electronic Resource
    Adaptation of the gastric mucosa to repeated administration of aspirin in the rat (1973)
    Springer
    Digestive diseases and sciences 18 (1973), S. 881-886 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of single and repeated doses of aspirin on the gastric mucosa of the rat were compared to determine whether the mucosal response alters after repeated aspirin. Aspirin (120 mg/kg) was administered by esophageal intubation either as a single dose or daily for 3, 14, 28 and 56 days. Mucosal damage was present in all treated rats but, on histologic quantitation, there was a highly significant reduction in the numbers of acute erosions in the groups receiving repeated daily aspirin. This apparent adaptation did not persist when aspirin administration was interrupted for 3 days. Repeated aspirin administration was not associated with any reduction in aspirin absorption or excretion, nor was there any significant change in hydrochloric acid or pepsin secretion. The investigation has shown an adaptation to repeated aspirin in the rat which appears to result from an alteration in the gastric mucosa. The precise mechanism of the adaptation remains uncertain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01073339
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  • 7
    Electronic Resource
    Electronic Resource
    Regeneration of gastric mucosa after aspirin-induced injury in the rat (1973)
    Springer
    Digestive diseases and sciences 18 (1973), S. 773-780 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Regeneration of gastric mucosa damaged by aspirin was studied in 6-week-old rats, using histologic and autoradiographic technics. Aspirin (120 mg/kg) was given by esophageal intubation either in a single dose or each day for 14 days. After a single dose, two types of lesion were observed in the mucosa of the body of the stomach: (a) superficial erosions which were already present after 30 minutes and which completely healed within 24 hours; (b) deeper erosions, reaching maximal numbers at 4 hours, which healed slowly with a median disappearance time of 5 days and which were associated with a focal increase in3H-thymidine-labeled cells. The peak increase in labeling occurred between 16 and 48 hours. The pattern and rate of healing was not altered by repeated daily aspirin. The investigation has demonstrated slow healing of deep mucosal erosions caused by aspirin; the slow healing can be explained by destruction of the progenitor zone by the initial injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01070847
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