ISSN:
1600-0536
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Primin (2-methoxy-6-pentyl-1,4-benzoquinone)is a naturally-occurring strong sensitizer from Primula obconica (Primulaceae), To determine the effect of side-chain length on senstizing potency 15 analogues with linear side chains from to from C1, to C15 and 4 C6- analogues with branched side chains were prepared synthetically and devoted to experimental sensitization in guinea pigs The results showed an increase of the sensitizing capacity with increasing length of the alkyl side chain from C1 to C10, reaching a maximum at C11 and C12. On further elongation the senstizing potency decreased beyond C13 reaching values which finally were as low as those of the C1 and C3 derivatives. The results mirror finding which finally were as low as those of the C1 and C3 derivatives. The results mirror findings which formerly have been obtained with other non-quinonoid compounds like catechols, phenols hydroquinones and gallates. In the plant kingdom. Compound approximating an “ideal allergen” consisting of a quinonoid ring with a 10 or 11 carbon-remarkably strong sensitizer found in Wigandia caracasana (Hydrophyllaceae)
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0536.1995.tb00440.x
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