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  • 1
    Electronic Resource
    Electronic Resource
    Neurotoxicity of antitumoral IL-2 therapy: Evoked cognitive potentials and brain mapping (1994)
    Springer
    Neurological sciences 15 (1994), S. 341-346 
    Details
    ISSN: 1590-3478
    Keywords: interleukin-2 ; neurotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La terapia antitumorale con interleuchina-2 (IL-2) è frequentemente associata a neurotossicità che si manifesta con disturbi neuropsichiatrici e, più raramente, con segni neurologici focali. Allo scopo di documentare l'interessamento delle funzioni cognitive dopo terapia con IL-2 abbiamo studiato 20 pazienti con potenziali evocati cognitivi (P300) e analisi computerizzata del segnale EEG. Nel confronto tra gli esami effettuati prima e dopo infusione sottocutanea di IL-2 abbiamo osservato un significativo allungamento della latenza media della P300 e un aumento percentuale delle frequenze EEG contenute nelle bande delta e teta, specie sulle regioni frontali.
    Notes: Abstract Antitumoral interleukin-2 (IL-2) therapy is frequently associated with a neurotoxicity that manifests itself in neuropsychiatric disturbances and, more rarely, with neurological focal signs. With the aim of documenting the involvement of cognitive functions after IL-2 treatment, we studied 20 patients using evoked cognitive potentials (P300) and computer analysis of the EEG signal. A comparison of the tests performed before and after the subcutaneous infusion of IL-2 showed a significant lengthening in mean P300 latencies and a percentage increase in the EEG frequencies contained with the delta and theta bands, especially in the frontal regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339930
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  • 2
    Electronic Resource
    Electronic Resource
    Paclitaxel neurotoxicity: clinical and neurophysiological study of 23 patients (1997)
    Springer
    Neurological sciences 18 (1997), S. 73-79 
    Details
    ISSN: 1590-3478
    Keywords: Paclitaxel ; Neurotoxicity ; Distal axonopathy ; Platinum-compounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Il Paclitaxel appartiene a una nuova categoria di farmaci antiblastici la cui attività è legata alla capacità di interferire con il sistema dei microtubuli. La neurotossicità periferica è dovuta all'interferenza con i microtubuli assonali e all'alterazione del trasporto assonale. Allo scopo di definire le caratteristiche cliniche e neurofisiologiche di questa neuropatia sono stati studiati 23 pazienti sottoposti a terapia con Paclitaxel al dosaggio di 175 mg/mq. I risultati dello studio hanno mostrato un'elevata incidenza di neurotossicità periferica di grado moderato, valutata con una scala di neurotossicità basata sui segni e sintomi clinici e sui dati neurofisiologici. L'insieme dei dati permette di definire la neuropatia da Paclitaxel come una neuropatia sensitivo-motoria distale di tipo assonale, la cui reversibilità richiede ulteriori conferme.
    Notes: Abstract Paclitaxel is the prototype of a new class of chemotherapeutic agents with an antimitotic effect that is related to its ability to interfere with the microtubule system. It causes peripheral neurological toxicity by means of its activity on the axonal microtubules. To define the clinical and neurophysiological characteristics of paclitaxel neuropathy 23 patients undergoing paclitaxel therapy at a dose of 175 mg/m2 were studied. The patients were divided into two groups, with only one group receiving pretreatment with potentially neurotoxic drugs such as cisplatin and carboplatin. The results showed a high incidence of mild neurotoxicity in both groups. Treatment was discontinued due to severe neurotoxicity in only one patient pretreated with platinum-compounds. The clinical and neurophysiological data make it possible to define paclitaxel neurotoxicity as a distal axonal neuropathy with a summatory effect in patients pretreated with cisplatin; the possible reversibility of paclitaxel neurotoxicity requires further confirmation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01999566
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Transport properties of poly(ethylene terephthalate) crystallized from the glassy state (1996)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 7 (1996), S. 858-862 
    Details
    ISSN: 1042-7147
    Keywords: PET ; crystallization ; mesomorphic form ; transport properties ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Poly(ethylene terephthalate) was crystallized from the glassy state at 120 and 200°C. The structural organization of samples, after the primary and secondary crystallizations, was analyzed by density, X-rays, infrared and transport properties of dichloromethane vapor. The values of crystallinity derived with different methods do not agree, indicating that the crystallized samples cannot be considered simply biphasic. Since the fraction of the impermeable phase is much higher than the fraction of the crystalline phase, it suggested that the presence of mesomorphic form, impermeable to the vapors at low activity. With this hypothesis, the complete composition of the crystalline samples, in terms of fraction of crystalline, amorphous and mesomorphic form was derived. A value of density of the mesomorphic form of 1.39 g/cm3 was also derived.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 4
    Electronic Resource
    Electronic Resource
    Transport properties of dichloromethane in glassy polymers. VI. Poly(ethylene terephthalate) (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 62 (1996), S. 1035-1041 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Sorption and diffusion of dichloromethane vapor in amorphous poly(ethylene terephthalate) (PET) were investigated, with the aim of studying how aging phenomena, at different temperatures, influence the transport properties. It has been found that aging produces the appearance of non-Fickian behavior in the sorption curves as well as the reduction of the diffusion coefficients. Furthermore, aging at 60°C reduces the sorption of vapor at low activity, and this led to the hypothesis of the presence of ordered domains in the aged samples. In this case, the process of solvent-induced crystallization is favored, and it appears at lower activity. © 1996 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 5
    Electronic Resource
    Electronic Resource
    Influence of ageing on the cold crystallization of glassy poly(ethyleneterephthalate) (1997)
    Springer
    Polymer bulletin 38 (1997), S. 579-585 
    Details
    ISSN: 1436-2449
    Keywords: Key words: Poly(ethyleneterephthalate) – Cold Crystallization – Kinetics of crystallization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. The thermal crystallization from the glassy state of different samples of Poly(ethyleneterephthalate) (PET) was investigated with different techniques, such as infrared and x-ray analysis and polarized optical microscopy. The different samples of PET were obtained by ageing the glassy PET films at room temperature and at 60 °C; the behaviour of these films was compared with that of the fresh sample, put at the crystallization temperature as soon as prepared. The temperature of crystallization was 120 °C. All the techniques, investigated to follow the crystallization phenomenon, show that the fresh sample crystallizes with longer times than the others. This result was correlated with the initial structural organization of the glassy amorphous films.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002890050091
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    Paper (German National Licenses)
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