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Effect of nitroglycerin on blood rheology in healthy subjects (1985)

Brügger, W. ; Imhof, P. ; Müller, P. ; [et al.]

Springer

European journal of clinical pharmacology 29 (1985), S. 331-336

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ISSN: 1432-1041

Keywords: nitroglycerin ; transdermal preparation ; blood viscosity ; plasma viscosity ; healthy volunteers ; haematocrit ; haemodilution

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Transdermal nitroglycerin (Nitroderm TTS 5) and a placebo were applied to 10 healthy male volunteers for 10 days. Before the first application and 6, 24, 48, 96, and 240 h thereafter, the viscosity of plasma and whole blood was measured and the packed-cell volume determined. During nitroglycerin application, the viscosity of plasma and whole blood was significantly diminished, and after 10 days it averaged 5% below the initial value. The greater the initial viscosity, the more marked was the druginduced reduction: in 5 subjects with plasma and whole-blood viscosities near the lower limit of the normal range, there was only a temporary decrease and the values reverted to their initial levels after 4 days; in the other 5 subjects, whose whole-blood viscosities were near the upper limit of the normal range, a 10% reduction was still demonstrable after 10 days. In those subjects all values measured throughout the 10-day observation period were significantly below the initial values. The haematocrit readings followed the same pattern as the alterations in viscosity. It can be assumed, therefore, that the decrease in viscosity induced by nitroglycerin results from “internal haemodilution”. The clinical relevance of the changes observed is discussed. The improvement in the rheological properties of the blood may contribute to the anti-anginal effect of Nitroderm TTS.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00544090

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Computer-aided tracking of body motions using a c.c.d.-image sensor (1978)

Brügger, W. ; Milner, Morris

Springer

Medical & biological engineering & computing 16 (1978), S. 207-210

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ISSN: 1741-0444

Keywords: Human locomotion ; Optoelectronics ; Kinesiology ; Charge-coupled devices ; Television ; Computer ; Tracking

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Description / Table of Contents: Sommaire C'est un détecteur d'image combiné à une charge (c.c.d.), qui servit à obtenir la trajectoire pratiquement droite des objects en déplacement sur un plan unique. Les données de l'image acquise sont enregistrées, puis traitées par différents programmes. Les résultats permettent ensuite d'effectuer une interprétation et des mesures. Le problème abordé par la thèse est celui des données kinésiologiques, alliées à la fonction locomotrice de l'être humain.

Abstract: Zusammenfassung Ein c.c.d.-Image-Sensor (Sensor mit ladungsgekoppelter Vorrichtung) wurde verwendet, um die Bahnen sich bewegender Objekte praktisch unmittelbar zu bestimmen. Die erhaltenen Bilddaten werden mittels mehrerer Programme gespeichert und verarbeitet und liefern Anzeigen, die Auswertung und Messung gestatten. Vor allem befassen wir uns mit kinesiologischen Daten in verbindung mit den Bewegungsfunktionen beim Menschen.

Notes: Abstract A c.c.d-image sensor has been used to obtain virtually online trajectories of moving objects in one plane. The image data acquired are stored and processed by several programs to yield displays which enable interpretation and measurement to be effected. Our major concern is in regard to kinesiological data allied with human locomotor function.