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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural Localization of Acid Phosphatase in Normal and X-lrradiated Epidermis (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 3 (1976), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Acid phosphatase activity has been studied in normal and X-irradiated rat epidermis. A remarkable reaction increment was found in irradiated epithelium at the granular layer keeping the same pattern of distribution observed in the normal tissue. No reactive lysosomes or keratinosomes were observed in the cytochemical sections, while many keratinosomes but no lysosomes appeared in the electron microscopic preparations of irradiated animals. Irradiated epithelium is discussed as a suitable model to analyze the role of acid phosphatase in the keratinization mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1976.tb00843.x
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  • 2
    Electronic Resource
    Electronic Resource
    Volumetric Modifications of X-Irradiated Keratinocytes (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 4 (1977), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The number of epithelial cells per unit volume of tissue (Nv) and the relative volume (Vv) occupied by the spinous and basal layers of X-irradiated and non-irradiated rat-tail epidermis were studied using techniques of stereologic cytology. By a simple calculation, the absolute volumes of basal and spinous keratinocytes were determined in irradiated (and in non-irradiated, control) epidermis, 24, 48, 72 and 96 h after exposure to a single dose of 16 Krads. During this post-irradiation period, the absolute volumetric values of both basal and spinous keratinocytes increased gradually, reaching a three-fold increase 96 h after irradiation. At the same time, the relative volume of the spinous layer increased from 58% to 75% of the total epidermis, whereas the volume fraction occupied by the basal layer decreased from 20% to 16%. These findings support previous evidence that lethally and sublethally damaged keratinocytes are capable of a metabolic effort resulting in a cell hypertrophy which in some circumstances could lead to repair and recovery from radiation damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1977.tb00884.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of total body irradiation on peri-implant tissue reaction: an experimental study (2001)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 12 (2001), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The aim of the present study was to evaluate the osseointegration process under total body irradiation conditions (LD 50/30). Twenty Wistar rats (mean body weight: 90 g) were used. Under ethyl urethane intraperitoneal anesthesia (1 g/kg body weight), the animals were irradiated with a single 700 cGy dose (linear accelerator 6 Mev photons). Four days post irradiation, a titanium laminar implant was placed in the left tibia of each rat. Antibiotic therapy (ceftriaxone) was administered daily post implantation, to prevent infection by radiation. Fourteen days post implantation, the animals were killed by ether overdose. The tibiae were resected, radiographed and processed for embedding in methyl methacrylate. The results showed impaired osteogenesis and absence of osseointegration in experimental tibiae. This could be due to a direct action of total body irradiation on osteogenesis precursor cells. This effect would impair bone formation involved in peri-implant osseointegration processes in this experimental model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.2001.120506.x
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of diphosphonate on the prevention of X-radiation-induced inhibition of bone formation in rats (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A histologic and histometric study of the effect of EHDP (ethane- 1–hydroxy-1,1–diphosphonate) on the alveolar wound healing of irradiated animals is presented. This drug was selected based on its osteosclerotic effect when applied at low doses. The three left mandibular molars of 80 male Wistar rats were extracted. The rats were grouped into 4 sets of 20 rats each. Group I received no further treatment; Group II received daily intraperitoneal injections of EHDP (7.5 mg/Kg of body weight during 10 days); Group III: 15 Gy of X-radiation were applied to the head; and Group IV were irradiated and injected with EHDP as were animals of Groups III and II. Half of the animals were killed after 14 days and the other half 30 days post-extraction. Sections were made at the level of the mesial socket of the first molar in a buccolingual orientation, on which histometric determinations of bone activity were made. The results showed the attenuation of the inhibitory effect of radiation on bone formation when the animals were treated with EHDP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00666.x
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  • 5
    Electronic Resource
    Electronic Resource
    Histometric study of leukoplakia, lichen planus and carcinoma in situ of oral mucosa (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 12 (1983), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Leukoplakia, lichen planus and carcinoma in situ of human oral mucosa were analysed histometrically by light microscopy. Leukoplakia lesions showed a greater total nuclear density than lichen planus lesions. They had a similar basal nuclear density to carcinomas in situ. The total and basal nuclear areas were notably greater in carcinomas in situ, indicating the presence of larger nuclei in comparison to those of other lesions. We believe it to be possible to make a differential diagnosis based on numerical variables.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1983.tb00344.x
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  • 6
    Electronic Resource
    Electronic Resource
    Histometric evalution of periodontal bone loss in rats (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 6 (1971), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of marginal irritation, trauma from occlusion and total body X-irradiation on interradicular bone of Wistar rat molars, was studied after an experimental period of two weeks. Histologic findings and slatistical evaluation of histometric results indicate that:〈list xml:id="l1" style="custom"〉– the only single factor capable of reducing the height of interradicular bone was marginal irritation,– the only additional factor that was capable of increasing this reduction in height was total body X-irradiation,– marginal irritation, either alone or in combination with trauma from occlusion increased bone density in the submarginal areat– total body X-irradiation inhibited the osteogenic reaction induced in the submarginal area by marginal irritation.– trauma from occlusion did not have any effect on the parameters measured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1971.tb00589.x
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  • 7
    Electronic Resource
    Electronic Resource
    A study of periodontal vascularization 10 different laboratory animals (1966)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 1 (1966), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The blood vessels of the periodontium of the rat, mouse, hamster, guinea pig, cat and dog were studied with Wachstein and Meisel's technique for the demonstration of adenosine-triphosphatase. In all species, a vascular plexus was found in the periodontal ligament, running in a general direction parallel to the long axis of the tooth and located closer to bone than to cementum. There was increased vascularity close to areas of active enamel formation (guinea pig molar and continuous growing incisors of all rodents). In the gingival tissues of all animals studied, an important annular plexus was found close to the epithelial cuff.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1966.tb01851.x
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  • 8
    Electronic Resource
    Electronic Resource
    Morphometric study of nucleolar organizer regions in human oral normal mucosa, papilloma and squamous cell carcinoma (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 21 (1992), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A morphometric study of nucleolar organizer regions (NOR) was performed to analyze their distribution, volume, number and shape in the different strata of human normal oral mucosa epithelium and papilloma and in squamous cell carcinoma employing microphotographs of silver-stained paraffin sections. The different NOR-related parameters evidenced significant differences between normal mucosa, papilloma and squamous cell carcinoma. The functional polarity of normal mucosa epithelium and of papilloma is also evidenced in terms of NOR-related parameters. The discriminative value of certain NOR parameters was demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1992.tb01010.x
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  • 9
    Electronic Resource
    Electronic Resource
    Alveolar wound healing alteration under uranyl nitrate intoxication (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 14 (1985), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The deposit of uranium compounds in calcifying zones has been demonstrated in hone. Nevertheless, no studies on the effect of uranium on osteogenesis have been performed. A histologic and histometric study of the effect of a single intraperitoneal injection of 2 mg/kg of body weight of uranyl nitrate on bone formation is presented. It was performed on rats' healing sockets. 14 days after tooth extraction. The alveolar bone volume (15 × 105μm2 vs. 34 × 105μm2), total bone formation areas (4.85% vs. 19.55%). and volume density of bone in the alveolar apical third (0.26 vs. 0.40) were significantly lower in intoxicated animals than in the controls. These results indicate the inhibitory effect of uranyl nitrate on bone formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1985.tb00530.x
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  • 10
    Electronic Resource
    Electronic Resource
    Salivary gland tumors induced by 32P (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The oncogenic power of 32P was demonstrated in salivary glands. An intraglandular injection of 0.25 mCi of chromic colloidal phosphate (32P) was administered to young adult Wistar rats. Seven months post-injection, tumors began to appear in the neck region in 64% of the rats. The tumors were sarcomas (50%), carcinomas (35.70%), and carcino-sarcomas (14.28%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01471.x
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