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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 33 (1986), S. 0 
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: . Agarose gel electrophoresis was used to identify metabolic enzymes in Babesia bovis and B. bigemina. Glutamate dehydrogenase, lactate dehydrogenase, glucose phosphate isomerase, and hexokinase were identified in B. bovis- and B. bigemina-infected erythrocytes and B. bovis merozoite preparations. A specific electrophoretic mobility was observed for each enzyme. Malate dehydrogenase, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and adenylate kinase were only detected in normal erythrocyte preparations. Inter-species, but not intra-species, variation was noted when comparing electrophoretograms of both species. Kinin-activating activity was not detected in B. bovis-infected erythrocyte or merozoite preparations at pH 4.2 or 7.6.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric radiology 26 (1996), S. 720-722 
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study 16 patients with severe spastic cerebral palsy with an age range between 6 months and 16 years were examined using videofluoroscopy and a modified barium meal. All patients were slow, inefficient eaters. Silent aspiration was demonstrated in five cases. The latter five patients demonstrated a delayed swallow reflex but there was little correlation between aspiration and the oral phase of deglutition. Our data confirms the impression that early diagnostic workup including videofluoroscopy is helpful in managing the feeding difficulties in these children, and may prevent chronic aspiration and malnutrition.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: Key words Heart failure ; Flosequinan; pharmacokinetics ; drug toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The pharmacokinetics of flosequinan were studied in a group of 18 patients with chronic cardiac failure. Results: After a single dose of 100 mg, Cmax of the parent compound (2.52 mg ⋅ l−1) was recorded at 1.4 h, and of the sulphone metabolite flosequinoxan at 21.7 h. The plasma elimination half lives of the parent compound (6.4 h) and of the metabolite (54.3 h) were prolonged compared to previous studies in normal volunteers. After repeated dose administration for 36 days, the kinetics of the parent compound and metabolite remained essentially unchanged with an expected significant accumulation of metabolite (Cmax 8.4 vs 3.21 mg ⋅ l−1). No adverse effects were observed. Conclusion: It is possible that altered drug kinetics in patients with heart failure, probably related to altered hepatic blood flow, could contribute to drug toxicity.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cent seize veaux de pure race Normande préalablement immunisés contre la babesiose et l'anaplasmose ont été transportés sur la côte des Caraībes de Colombie où ils ont été répartis en deux troupeaux de même nombre, chacun d'eux placé sur des pâturages naturels particuliers. Un des deux groupes a été l'objet d'une infestation massive de la part deBoophilus microplus, alors que l'autre n'était que légèrement infesté par cette tique. Les veaux appartenant au groupe très atteint ont accusé une perte moyenne de poids de l'ordre de 38 kg et un abaissement de 48 p. 100 de l'hématocrite moyenne. Vingt trois c'est-à-dire 40 p. 100 des animaux sont morts entre le 16e et le 39e jour après leur arrivée, à la suite de sévères attaques d'anaplasmoses et de babesioses—chez les animaux constituant le groupe seulement légèrement parasité par cette tique la mortalité et les pertes de poids n'ont pas atteint de niveau significatif.
    Abstract: Resumen Se llevaron 116 terneros Normando puros a la costa del Caribe en Colombia, previa inmunización contra anaplasmosis y babesiosis. Los animales se divideron en dos grupos iguales y se pusieron en praderas diferentes. Uno de los grupos sufrió una infestación severa conBoophilus microplus. La pérdida de peso en este grupo promedió 38 kg y el hematocrito en general descendió un 48%. Veintitres animales (40%) murieron de ixodiasis y babesiosis 16 y 39 días después del arribo. En el segundo grupo, el cual tuvo una infestación ligera de garrapatas, no hubo mortalidad y las pérdidas fueron insignificantes.
    Notes: Summary One hundred and sixteen pure-bred Normandy calves previously immunised against babesiosis and anaplasmosis were transported to the Caribbean Coast of Colombia where they were divided into 2 equal groups and placed in separate pastures. One group sustained heavy infestation withBoophilus microplus ticks. The second group became lightly infested. The heavily infested calves suffered average losses in body weight of 38 kg and a 48% decrease in mean packed cell volume. Twenty-three (40%) died 16 to 39 days following arrival from severe ixodiasis and babesiosis. Mortality did not occur nor were significant weight losses observed in the group of lightly infested calves.
    Type of Medium: Electronic Resource
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