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  • 1
    Electronic Resource
    Electronic Resource
    IgG anti-IgE in circulating immune complexes in the hyper-IgE syndrome (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 16 (1986), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. We fractionated, by gel chromatography, sera with high IgE content from atopic subjects and five cases with the hyper-lgE syndrome, and measured the presence of IgE in high molecular weight (HMW) fractions. Two out of four asthmatics and four out of five hyper-IgE had HMW IgE. The same serum fractions gave positive results for conglutinin binding IgG (all six) and IgA (three cases) as well as C1q binding complexes (five cases). IgG auto-antibodies to IgE were also detected together with IgE in HMW fractions. Anti-F(ab)'2 activity was present in five cases (one of them negative for IgG anti-IgE). Our data indicate that complexes made of IgE and IgG anti-IgE are present mainly in patients with chronic allergic symptoms and most frequent in cases of hyper-IgE syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1986.tb01989.x
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  • 2
    Electronic Resource
    Electronic Resource
    T-cell receptor genes and ataxia telangiectasia (1985)
    [s.l.] : Nature Publishing Group
    Nature 313 (1985), S. 186-186 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - The nature of the T-cell antigen receptor has been recently discussed in News and Views1. The genes for the b chain of the T-cell receptor have been cloned and mapped and human chromosome 7, bands 7pl3-212, while the a-chain genes still await chromosomal assignment. We wish to draw attention ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/313186a0
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  • 3
    Electronic Resource
    Electronic Resource
    Variant of ataxia-telangiectasia with low-level radiosensitivity (1985)
    Springer
    Human genetics 〈Berlin〉 70 (1985), S. 274-277 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the present study we examined cells from several patients clinically diagnosed as having ataxia-telangiectasia (AT), for the capacity of their cells to inhibit DNA synthesis following exposure to gamma irradiation, and for the rate of spontaneous or blcomycin-induced chromosomal aberrations. Cells from two patients showed normal inhibition of DNA synthesis and levels of induced chromosomal aberrations intermediate between normal and AT cells. These two patients had only minimal immunologic impairment. These findings appear to define one distinct subset of AT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273456
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Epidemiological aspects of HTLV-III infection in Italy (1985)
    Springer
    European journal of epidemiology 1 (1985), S. 288-293 
    Details
    ISSN: 1573-7284
    Keywords: AIDS ; HTLV-III ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An epidemiological survey on the presence of serum antibodies to human T lymphotropic retrovirus III (HTLV-III) is reported. The study was carried out on people living in large as well as small cities in different Italian regions. Serum samples of 21 patients with AIDS, 402 with ARCS, and 920 from individuals at risk for these diseases were analyzed. The percentage of positive sera varied from 81% in AIDS, to 100% −33.3% in ARC according to the different geographical areas and/or the various categories of people with ARC. The percentage of positive sera in individuals at risk for AIDS or ARC varied from 11.9% in homosexuals, to 21% in drug abusers and 23.1% in haemophiliacs. No positive sera were observed among 660 normal individuals, relatives of patients with AIDS or ARC and in 114 patients suffering from immunological or infectious disease and among people at risk living in small cities. Sera were also negative in patients with classical Kaposi's sarcoma or T-cell chronic lymphocytic leukemia. Since none of the 660 unselected normal adults were positive while a significant percentage of people at risk for AIDS showed antibodies to HTLV-III, we may presume that this infection is prevalent in the Italian categories in which AIDS and ARC are most likely to develop.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237104
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  • 5
    Electronic Resource
    Electronic Resource
    Absence of antibodies to human herpesvirus-6 in patients with slowly-progressive human immunodeficiency virus type I infection (1992)
    Springer
    European journal of epidemiology 8 (1992), S. 217-221 
    Details
    ISSN: 1573-7284
    Keywords: HHV-6 ; HIV-1 ; CD4 ; Progression rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate a possible role for Human Herpesvirus-type 6 (HHV-6) coinfection as a co-factor in the progression of HIV-1 disease, we investigated the prevalence of seropositivity for HHV-6 in a cohort of HIV-1 infected patients. These patients were retrospectively divided into two groups according to the decline of CD4+ T cells during the follow up: 11 were classified as rapid decliners (〈 400 CD4+/cmm within 1 year), and 38 as slow decliners (〉 400 CD4+/cmm after at least 4 years' follow up). HHV-6 antibodies were detected by a commercial immunofluorescence assay and by a Western blotting assay developed in our laboratory. Our results show that Western blot appears to provide results satisfactorily free of false positivities. We found that the frequency of HHV-6 seropositivity was significantly lower in the group of slow decliners, compared both to rapid decliners and to the general population. These data suggest a role for HHV-6 co-infection in the progression of HIV-1 disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00144803
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    Paper (German National Licenses)
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