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  • 1
    Electronic Resource
    Electronic Resource
    Multidrug resistance-associated protein (MRP1) gene is strongly expressed in gastric carcinomas. Analysis by immunohistochemistry and real-time quantitative RT-PCR (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : To assess MRP1 protein and MRP1 mRNA levels in gastric carcinomas and in non-neoplastic mucosa remote from the tumours. MRP1 gene expression may play a role in the complex pattern of chemoresistance present in gastric carcinomas.Methods and results : A total of 57 carcinomas and respective gastric tissues were included for immunohistochemical assessment with the anti-MRP1 monoclonal antibodies MRPr1 and QCRL-1. Of these, 35 tumour and gastric mucosa tissues were also assessed by real-time quantitative reverse transcriptase-polymerase chain reaction. Medium or high MRP1 protein expression was detected in 89% and 77% of carcinomas and in 96% and 93% of non-neoplastic gastric mucosa by MRPr1and QCRL-1, respectively. No difference in MRP1 mRNA levels was detected between carcinomas and non-neoplastic gastric mucosa tissues in 77% of the patients. A significant correlation was found between MRP1 mRNA level and protein expression detected in carcinomas related to non-neoplastic gastric mucosa, although they were non-concordant in 29% of the patients.Conclusions : MRP1 gene is usually expressed in most gastric carcinomas and does not differ substantially from that observed in non-neoplastic gastric mucosa remote from the tumour. However, a decrease in MRP1 gene expression is found in some carcinomas. For accurate assessment of changes in MRP1 expression between tumour and normal tissues both protein and mRNA detection are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02100.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mikrophotographische Darstellung der wirklichen interstitiellen Zellen von Cajal (1965)
    Springer
    Journal of neural transmission 27 (1965), S. 496-510 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Photographical reproduction of some original slides ofCajal with some translations of the first papers of these autor concerning the interstitiell cells.
    Abstract: Résumé Reproduction photographique de quelques préparations originales deCajal avec quelques traductions des premiers travaux de cet auteur au sujet des cellules interstitilles.
    Notes: Zusammenfassung Phtographische Wiedergabe einiger alter Originalpräparate vonCajal nebst einigen Übersetzungen der ursprünglichen Veröffentlichungen dieses Autors über die interstitiellen Zellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01237112
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  • 3
    Electronic Resource
    Electronic Resource
    Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with weekly high-dose 48-hour continuous-infusion fluorouracil for advanced colorectal cancer: A Spanish Cooperative Group for Gastrointestinal Tumor Therapy (TTD) study (1998)
    Springer
    Annals of oncology 9 (1998), S. 727-731 
    Details
    ISSN: 1569-8041
    Keywords: advanced colorectal cancer ; biochemical modulation ; continuous infusion ; fluorouracil ; phase III trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The objective of this multicenter study was to compare the efficacy and toxicity profiles of a combination of 5-fluorouracil (5-FU) given by bolus injection together with intravenous leucovorin (LV) versus high-dose 5-FU in continuous infusion (CI) in the treatment of advanced colorectal cancer. Patients and methods: A total of 306 patients were randomized to receive either 5-FU 425 mg/m2 given by bolus injection on days 1–5 plus intravenous (i.v.) LV 20 mg/m2 every four to five weeks or 5-FU 3.5 g/m2/week in a 48-hour CI. Therapy was continued until disease progression. Second-line chemotherapy was allowed in both arms. Results: The response rates in 306 patients with measurable lesions were 19.2% (modulated arm) and 30.3% (CI arm, P 〈 0.05). The median progression-free survival times were 23.5 weeks (modulated arm) and 25 weeks (CI arm, P = NS). Median survival times were 42.5 weeks (modulated arm) and 48 weeks (CI arm, P = NS). There were no significant differences in grade 3–4 toxicity profiles but if we consider all grades we observed more mucositis in the modulated arm and more hand-foot syndrome in the CI arm. Conclusions: In terms of response rate, the continuous infusion regimen was more effective than the modulated regimen. There was no significant difference in survival and time to progression, and none in grade 3–4 toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008282824860
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  • 4
    Electronic Resource
    Electronic Resource
    Validity of the hospital discharge diagnosis in epidemiologic studies of biliopancreatic pathology (2000)
    Springer
    European journal of epidemiology 16 (2000), S. 533-541 
    Details
    ISSN: 1573-7284
    Keywords: Biliary and pancreatic neoplasms – diagnosis ; Epidemiology ; Multicentre studies ; Validity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The aim was to analyse the magnitude, direction and predictors of change in the main hospital discharge diagnosis (HDD) after a clinical expert review, among patients included in a multicentre molecular epidemiologic study of biliopancreatic diseases. Methods: A total of 602 patients with a suspicion diagnosis of pancreas cancer (PC), cancer of the extrahepatic biliary system (CEBS) or benign biliopancreatic pathologies (BPP) were prospectively recruited at five general hospitals. A structured form was used to collect information from medical records. A panel of experts revised all diagnostic information and established the main clinico-pathological diagnosis (CPD) by consensus. Results: Of the 204 cases with a HDD of PC, 176 (86%) were deemed to have a CPD of PC, eight of CEBS, twelve a neoplasm of different origin, four BPP and four syndromic diagnoses. Thus, 28 cases (14%) were false positives. Of the 129 patients with a HDD of CEBS, 15 (12%) were false positives. Nine of the 396 cases with a HDD of non-PC (2%) had a CPD of PC (false negatives), whilst 14 of 471 patients with a HDD of non-CEBS (3%) were deemed to have CEBS. Overall, sensitivity and specificity of HDD for PC were, respectively, 95 and 93%, and for CEBS, 89 and 97%. Cytohistological confirmation and laparotomy were independent predictors of diagnostic change. Conclusions: Validity of the HDD was high, but its association with some clinical variables suggests that sole reliance on HDD can significantly bias results, and highlights the need to review all HDDs. Alternatively, only patients at high risk of misdiagnosis could be reviewed: primarily, those lacking a cytohistological diagnosis or a laparotomy. No exclusions appear warranted solely on the basis of age, gender or tumour spread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007692408457
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  • 5
    Electronic Resource
    Electronic Resource
    Medical Conditions in Patients with Pancreatic and Biliary Diseases (Validity and Agreement Between Data from Questionnaires and Medical Records) (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 2469-2477 
    Details
    ISSN: 1573-2568
    Keywords: PANCREATOBILIARY DISEASES ; MEDICAL HISTORY ; INTERVIEW DATA ; PREVALENCE ; AGREEMENT ; VALIDITY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aims of the study were to assess theagreement between data from personal interviews andmedical records on selected medical conditions, toevaluate the validity of each source of information, andto estimate the prevalence of these conditions inpancreatobiliary pathology. Between 1992 and 1995, 602patients with pancreatobiliary diseases were included inthe PANKRAS II Study. Information from interview and medical records was available in 88% ofcases. The agreement between both data sources was pooronly for cholecystitis and mental disorders. Thevalidity of both sources of information was high oracceptable for all conditions except for cholecystitis.Prevalence of past medical conditions was similar tothat reported previously and varied according todiagnosis, gender, age, educational level, and hospital of admission. Research aimed at assessing theprevalence of less common diseases should considersubject- and health-related factors in collectinginformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026635005363
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