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  • 1
    Electronic Resource
    Electronic Resource
    Liquid chromatographic determination of flunarizine in human plasma
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 374 (1986), S. 196-199 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0378-4347(00)83271-5
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cardiovascular response to exercise in diabetic patients: influence of autonomic neuropathy of different severity (1995)
    Springer
    Diabetologia 38 (1995), S. 244-250 
    Details
    ISSN: 1432-0428
    Keywords: Key words Exercise ; diabetic autonomic neuropathy ; postural hypotension ; cardiovascular response ; catecholamines ; diabetic cardiomyopathy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated cardiovascular function and plasma catecholamine response during incremental exercise and recovery in diabetic patients with (DAN+) and without autonomic neuropathy (DAN−). The former group was divided according to the presence of parasympathetic (DAN+PH−) or associated parasympathetic and sympathetic (DAN+PH+) damage to the autonomic nervous system. A group of healthy volunteers was studied as a control group. All the patients and control subjects underwent a submaximal or symptom-limited incremental exercise test using a cycle-ergometer. Air flow and respiratory gas fractions were sampled at the level of the mouth allowing a breath-by-breath analysis of oxygen consumption (VO2). Heart rate and systolic blood pressure were recorded and venous blood samples were obtained from the patients at rest and during each minute of exercise and recovery to measure norepinephrine and epinephrine plasma levels. Haemodynamic parameters and plasma catecholamines were computed at rest and at 25, 50, 75 and 100 % of the peak VO2 (VO2 max). The breath-by-breath relationships among VO2, heart rate and VO2/heart rate against work were assessed during exercise for patients and control subjects. While VO2 max in absolute values was not significantly different among the diabetic groups, VO2 max was much less in diabetic patients than in control subjects (p 〈 0.01). During exercise the rate of heart rate, systolic blood pressure, norepinephrine and epinephrine increase was different among the diabetic groups, being significantly blunted in DAN+PH+. The VO2/work relationship of the three diabetic groups was similar but markedly reduced in respect to that of control subjects (p 〈 0.001). The relationship between oxygen pulse (VO2/heart rate) and work showed no differences among the diabetic groups, whereas its slope was significantly steeper in control subjects (p 〈 0.01 vs DAN−; p 〈 0.05 vs DAN+PH− and DAN+PH+). In conclusion during incremental exercise both DAN+PH− and DAN+PH+ exhibit abnormal heart rate, systolic blood pressure and catecholamine responses which, however, appear clearly distinct between the two groups of DAN+. In DAN+ the VO2 increment is reduced during exercise. Since DAN− show the same impairment, this particular finding seems most likely to be influenced by factors (i. e.: diabetic cardiomyopathy) other than overt autonomic neuropathy. [Diabetologia (1995) 38: 244–250]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400101
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cardiovascular response to exercise in diabetic patients: influence of autonomic neuropathy of different severity (1995)
    Springer
    Diabetologia 38 (1995), S. 244-250 
    Details
    ISSN: 1432-0428
    Keywords: Exercise ; diabetic autonomic neuropathy ; postural hypotension ; cardiovascular response ; catecholamines ; diabetic cardiomyopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated cardiovascular function and plasma catecholamine response during incremental exercise and recovery in diabetic patients with (DAN+) and without autonomic neuropathy (DAN−). The former group was divided according to the presence of parasympathetic (DAN+PH−) or associated parasympathetic and sympathetic (DAN+PH+) damage to the autonomic nervous system. A group of healthy volunteers was studied as a control group. All the patients and control subjects underwent a submaximal or symptom-limited incremental exercise test using a cycle-ergometer. Air flow and respiratory gas fractions were sampled at the level of the mouth allowing a breath-by-breath analysis of oxygen consumption (VO2). Heart rate and systolic blood pressure were recorded and venous blood samples were obtained from the patients at rest and during each minute of exercise and recovery to measure norepinephrine and epinephrine plasma levels. Haemodynamic parameters and plasma catecholamines were computed at rest and at 25, 50, 75 and 100% of the peak VO2 (VO2 max). The breath-by-breath relationships among VO2, heart rate and VO2/heart rate against work were assessed during exercise for patients and control subjects. While VO2 max in absolute values was not significantly different among the diabetic groups, VO2 max was much less in diabetic patients than in control subjects (p〈0.01). During exercise the rate of heart rate, systolic blood pressure, norepinephrine and epinephrine increase was different among the diabetic groups, being significantly blunted in DAN+PH+. The VO2/work relationship of the three diabetic groups was similar but markedly reduced in respect to that of control subjects (p〈0.001). The relationship between oxygen pulse (VO2/heart rate) and work showed no differences among the diabetic groups, whereas its slope was significantly steeper in control subjects (p〈0.01 vs DAN−; p〈0.05 vs DAN+PH− and DAN+PH+). In conclusion during incremental exercise both DAN+PH− and DAN+PH+ exhibit abnormal heart rate, systolic blood pressure and catecholamine responses which, however, appear clearly distinct between the two groups of DAN+. In DAN+ the VO2 increment is reduced during exercise. Since DAN−show the same impairment, this particular finding seems most likely to be influenced by factors (i.e.: diabetic cardiomyopathy) other than overt autonomic neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400101
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Multicentre comparison of cephacetrile and ampicillin in the treatment of urinary tract infections (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 331-336 
    Details
    ISSN: 1432-1041
    Keywords: Cephacetrile ; ampicillin ; urinary tract infections ; renal function ; multicentre trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The efficacy and tolerability of cephacetrile and ampicillin in the treatment of urinary tract infections have been compared in a between patient, single blind, multicentre controlled trial. 68 in-patients were treated with cephacetrile or ampicillin in doses of 1 to 4 g/day, according to their creatinine clearances, for an average of 10 days. The two drugs had similar therapeutic effects, i.e. they produced significant decreases in leucocyturia (p〈0.001) and urinary culture colony counts (p〈0.001). No side effects were observed. The direct Coombs' test remained negative in all patients, even in those with advanced renal failure. To determined whether renal function was affected by treatment, creatinine clearance, and cylindruria, erythrocyturia and proteinuria were assessed in 24 h urine samples, before and after drug administration. None of these parameters were altered, except for a decrease in cylindruria (p〈0.05) after cephacetrile. It was concluded that cephacetrile was as active as ampicillin in the treatment of urinary tract infections and that there was no evidence of nephrotoxicity in the doses employed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558201
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Computer analysis of saccadic eye movements: assessment of two different carbamazepine formulations (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 513-516 
    Details
    ISSN: 1432-1041
    Keywords: carbamazepine ; slow-release formulations ; saccadic eye movements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The central effects of two different formulations of Carbamazepine (CBZ) have been examined by analysis of saccadic eye movements (SEM) in 6 healthy volunteers, who took part in a double-blind latin-square, placebo controlled study. Both a conventional- and a controlled-release formulation of CBZ produced a significant effect on peak saccadic velocity and saccade accuracy, but only the former affected saccade latency. Computer analysis of SEM confirmed it to be a highly sensitive method for detection of subclinical drug effects on the CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558133
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    Paper (German National Licenses)
    Fulltext
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