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  • 1
    Electronic Resource
    Electronic Resource
    AB0 blood groups and the type of leprosy in an Indian population (1966)
    Springer
    Human genetics 〈Berlin〉 3 (1966), S. 186-188 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In 931 leprosy patients from Bankura, West Bengal, India, the relationship between the AB0 blood group and the immunological type of leprosy (lepromatous vs. nonlepromatous) was examined. Among the 472 lepromatous patients, there was a slight excess of blood group A (and also AB and B) as compared with the nonlepromatous group. This excess was not significant statistically in our material. However, combination of the data with those published by Beiguelman (1964) from Brazil and Yankah (1965) from Ghana renders a significantly higher incidence of group A (and probably B and AB) in lepromatous patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291299
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  • 2
    Electronic Resource
    Electronic Resource
    Hb E gene in imphal, manipur (India) (1979)
    Springer
    Human genetics 〈Berlin〉 51 (1979), S. 209-211 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00287177
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  • 3
    Electronic Resource
    Electronic Resource
    Haemagglutination-inhibiting variola antibodies in blood serum of former smallpox patients, their healthy siblings, and unvaccinated controls from other areas (1971)
    Springer
    Human genetics 〈Berlin〉 11 (1971), S. 336-338 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung 50 früher an Pocken erkrankte Inder, 50 Geschwister dieser Patienten, die selbst nie an Pocken erkrankt waren, sowie 44 Personen aus Dörfern, die in den letzten Jahren keine Pockenepidemie durchgemacht hatten, wurden bezüglich der Variola-Antikörper miteinander verglichen. Alle untersuchten Personen waren niemals gegen Pocken geimpft worden. Die Verteilung der Titerwerte bei früher Erkrankten und bei ihren nicht erkrankten Geschwistern stimmte überein, während die dritte Gruppe im Durchschnitt geringere Werte zeigte.
    Notes: Summary Haemagglutination-inhibiting variola antibodies were compared in 50 smallpox survivors (P), 50 siblings who had shown no signs of smallpox (CI) and 44 persons living in villages which had apparently been free of the infection during recent years (CII). Only unvaccinated persons were examined. Distribution of titres was identical in groups P and CI, whereas the average values in group CII were lower.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278662
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  • 4
    Electronic Resource
    Electronic Resource
    Inv phenotypes and quantitative gamma globulin determinations in leprosy patients and control populations from India and Thailand (1971)
    Springer
    Human genetics 〈Berlin〉 12 (1971), S. 35-41 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Zwei Probleme wurden untersucht: 1. Besteht eine Beziehung zwischen der Häufigkeit und dem klinischen Verlauf der Lepra und dem Inv(1)-Polymorphismus? 2. Beeinflussen die Inv(1)-Typen die Gammaglobulinmenge im Serum? Material: 961 Inder (302 mit lepromatöser, 284 mit nichtlepromatöser Lepra; 375 Kontrollen) aus 5 verschiedenen Kasten und aus den Distrikten Bankura und Purulia, West-Bengalen, 494 Leprapatienten aus Thailand (240 mit lepromatöser, 254 mit nichtlepromatöser Lepra); 988 Kontrollen. Diese Kontrollgruppe wurde nur auf dem Inv-Typ, nicht auf Gammaglobuline hin untersucht. Ergebnisse: 1. Es besteht offenbar keine Beziehung zwischen Lepra und Inv-Typ. 2. Es konnte keine Beziehung zwischen dem Inv-Typ und dem Gammaglobulingehalt des Serums aufgefunden werden. 3. Die Phänotyp-Häufigkeiten im Inv-System bewegen sich im Rahmen dessen, was für andere indische und asiatische Populationen bekannt ist.
    Notes: Summary Two problems were examined: 1. Is there an association between prevalence and clinical course of leprosy and the Inv(1) polymorphism? 2. Do the Inv(1) types influence the amount of gamma globulin present in the serum? Material: 961 Indians (302 with lepromatous, 284 with nonlepromatous leprosy; 375 controls) from 5 different caste groups, districts of Bankura and Purulia, West Bengal; 494 leprosy patients from Thailand (240 with lepromatous, 254 with nonlepromatous leprosy); 988 controls; this control group was examined only for Inv type, not for gamma globulins. Results: 1. There seems to be no association between leprosy and Inv type. 2. No association between Inv type and gamma globulin content of the serum was found. 3. The phenotype frequencies in the Inv system are within the range known for other Indian and Asian populations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291030
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  • 5
    Electronic Resource
    Electronic Resource
    High prevalence of Haemoglobin E in two populations in Assam (1971)
    Springer
    Human genetics 〈Berlin〉 12 (1971), S. 264-266 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Zwei Bevölkerungsgruppen in Assam (Indien) wurden untersucht. Bei 80 Khasi (Bhoi-Untergruppe), einem austroasiatischen Stamm, fanden sich 41% HbE-Träger, bei 82 Ahom, Abkömmlingen von Thai-Einwanderern, 58% HbE-Träger. Die große Häufigkeit des HbE in Gruppen mit ethnischen Beziehungen zu Südostasien unterstützen die Ansicht, daß das HbE-Gen von dort nach Indien eingeführt wurde.
    Notes: Summary Two groups in Assam (India) were examined. Among 80 Khasi (Bhoi subgroup), an austroasiatic tribal group, there were 41% HbE carriers; and in 82 Ahom, a group related to the Thai population, 58% of HbE carriers were found. This high prevalence of HbE in groups with ethnic relations to Southeast Asia supports the contention that the HbE gene was introduced to India from that area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702780
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  • 6
    Electronic Resource
    Electronic Resource
    AB0 blood groups, inv serum groups, and serum proteins in leprosy patients from West Bengal (India) (1971)
    Springer
    Human genetics 〈Berlin〉 12 (1971), S. 284-301 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die Beziehungen zwischen AB0-Blutgruppen sowie Häufigkeit, Typ und Verlauf der Lepraerkrankung wurden an 1034 Indern aus West-Bengalen (Lepra-Patienten und normalen Kontrollen) untersucht. In dieser Serie fanden sich keine Beziehungen. Eine kombinierte Analyse von 41 Serien aus der Literatur (unsere eingeschlossen) gibt eine gering, aber signifikant erhöhte Häufigkeit der Gruppen A und AB im Vergleich zu B und 0 bei Lepra-Patienten. Die Gruppen A, B und AB sind im Gesamtmaterial ebenfalls etwas häufiger bei lepromatöser im Vergleich zu nichtlepromatöser Lepra. Bei 683 Lepra-Patienten aus Thailand hatten wir zuvor eine Verminderung der α2-globuline bei Gruppen A und AB im Vergleich zu B und 0 beschrieben. Dieser Befund wurde an dem indischen Material bestätigt. Bei den thailändischen Patienten fanden sich auch Hinweise für eine Beziehung zwischen AB0- und Serum Inv-Gruppen: Personen, die sowohl A oder AB als auch den Typ Inv (1) aufwiesen, waren signifikant häufiger als erwartet. Dieser Befund konnte jedoch in dem indischen Material nicht bestätigt werden.
    Notes: Summary The associations between ABO blood groups and prevalence as well as type and severity of the leprosy infection were examined in 1034 Indians from West Bengal (leprosy patients and normal controls). There are no associations in the present series; combined analysis of 41 series from the literature (ours included) gives a slightly, but significantly higher frequency of groups A and AB as compared to B and 0 in leprosy patients. Groups A, B, and AB are also somewhat more frequent in lepromatous as compared with nonlepromatous leprosy. A lower level of α2-globulins in the serum of leprosy patients of groups A and AB as compared with patients of groups B and 0, which had been described earlier in 683 leprosy patients from Thailand, was confirmed in the present series. In the Thai series of patients, a significant association between the AB0 blood groups and the Inv serum groups was observed: Persons having blood group A and AB as well as the Inv (1) type were significantly more frequent than expected. This association, however, was not confirmed in the Indian material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278049
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  • 7
    Electronic Resource
    Electronic Resource
    AB0 blood groups and smallpox in a rural population of West Bengal and Bihar (India) (1966)
    Springer
    Human genetics 〈Berlin〉 3 (1966), S. 166-180 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The problem was reexamined whether there is a relationship between the AB0 blood groups and incidence, severity and outcome of smallpox. In persons suffering from smallpox, and living in rural areas of West Bengal and Bihar, India, severity and outcome of the disease were registered, and the AB0 blood groups were determined. Healthy siblings were used as controls for incidence. Four series were available: 1. 200 suffering patients and 200 controls examined during summer 1965 in the Burdwan district. West Bengal. 2. 237 suffering patients and 228 controls examined during spring 1966 in West Bengal and Bihar. 415 of the cases contained in series 1 and 2 had never been vaccinated; the mortality was about 50%. 3. 402 survivors of a 1964 epidemic, who were examined during the 1965 survey in the Burdwan district, and 350 control siblings. 4. 147 survivors of the 1966 epidemic who were examined during the 1966 survey in the same area. Relative incidence of smallpox was shown to the much higher in suffering patients of groups A and AB, when compared with the healthy siblings (x=6.09; χ2 (DF=1)=128.92). Within the patient group, severe forms and fatal outcome were significantly more frequent in groups A and AB as compared with groups B and 0. The surviving cases showed a much higher frequency of groups B and 0 than the fresh cases of the same area, indicating a much higher mortality of A and AB persons also in these series. Within the group of survivors, severe smallpox scars were significantly more frequent in groups A and AB. The combined results of an examination of 986 smallpox patients and 778 controls gave conclusive evidence in favour of a strong disadvantage of groups A and AB towards the smallpox infection. However, as comparison with other series shows, the influence of the blood group seems to be confined to severe manifestations in unvaccinated persons who are living under natural, primitive conditions without medical care. Some immunological implications of the result are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291297
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  • 8
    Electronic Resource
    Electronic Resource
    Hp, Gc, Cp, Tf, Bg and Pi phenotypes in leprosy patients and healthy controls from West Bengal (India) (1972)
    Springer
    Human genetics 〈Berlin〉 14 (1972), S. 314-325 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung An einer Stichprobe von n=601 Leprakranken und n=386 gesunden Kontrollen aus West-Bengalen (Indien) wird die Frage untersucht, ob und inwieweit Beziehungen zwischen der Lepra und verschiedenen Serumproteingruppen wie Haptoglobin, Gc, Ceruloplasmin, Transferrin, β 2 I und Pi bestehen. Bezüglich der Haptoglobinund Transferrin-Gruppen wurden keine Beziehungen gefunden, während für die Ceruloplasmin-, β 2 I- und Pi-Phänotypen gewisse Beziehungen nachgewiesen werden konnten. Diese Beziehungen, die sich z. T. auch auf die verschiedenen Lepratypen und klinischen Verlaufsformen dieser Krankheit erstrecken, müssen jedoch an weiteren Materialien nachgeprüft werden. Die auffallendsten Befunde konnten bezüglich der Gc-Proteine gemacht werden. In Übereinstimmung mit früheren Beobachtungen an Stichproben aus Brasilien und insbesondere aus Moçambique konnte ein statistisch hochsignifikanter Überschuß an Gc 1-1-Phänotypen bei Leprakranken festgestellt werden. Dies dürfte auf einen Zusammenhang zwischen der Lepra und den Gc-Proteinen hinweisen, der jedoch durch weitere genetische und pathophysiologische Untersuchungen abzusichern ist.
    Notes: Summary On a sample of n=601 leprous individuals and n=386 healthy controls from West Bengal (India) the question is discussed, if there are existing any associations between leprosy and several serum protein groups like haptoglobin, Gc, ceruloplasmin, transferrin, β 2 I and Pi. No associations were found concerning the haptoglobins and transferrins. Certain associations came out respecting ceruloplasmin, β 2 I and Pi phenotypes. However, these associations, which were found in connection with the different types and clinical courses of leprosy, should be reexamined by further research. The most striking results were obtained concerning the Gc proteins. In accordance with previously performed investigations on Brazilians and in particular on Negroes from Moçambique statistically high significant surplusses of Gc 1-1 phenotypes in individuals suffering from leprosy could be demonstrated. This indicates in our opinion the existence of a relationship between Gc proteins and leprosy, which, however, must also be disclosed by further genetical and especially by pathophysiological research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290173
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  • 9
    Electronic Resource
    Electronic Resource
    Relation between smallpox and the AB0 blood groups in a rural population of west Bengal (1966)
    Springer
    Human genetics 〈Berlin〉 2 (1966), S. 78-80 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285912
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  • 10
    Electronic Resource
    Electronic Resource
    A statistical appraisal on the relationship between non-ABO blood group systems and diseases (1967)
    Springer
    Human genetics 〈Berlin〉 5 (1967), S. 1-27 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The present review was visualised as a search for relationship between non-ABO blood group systems including the AB(H) secretor types and susceptibility to representative group of diseases associated with various systems of the body. The materials were collected from all publications available to us during 1950–1967. For statistical evaluation, the method of Woolf (1955) was followed. It becomes evident from the various reports that many of the authors were aware of the possible biases, and did their best to avoid them. Three degrees of probabilities have been considered. The possible association of certain diseases to particular blood groups or types has been discussed. It is the main purpose of this review to show, where there are possible relationships, and to encourage further investigations in the same direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286207
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