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  • 1
    Digitale Medien
    Digitale Medien
    Amino acid incorporation in protein during the “silent phase” before organo-mercury andp-bromophenylacetylurea neuropathy in the rat (1971)
    Springer
    Acta neuropathologica 19 (1971), S. 216-224 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Protein Incorporation ; Amino Acids ; p-Bromophenylacetylurea ; Neuropathy ; Neurotoxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The incorporationin vivo of14C-glycine into proteins has been studied during the period before and after the onset of neurotoxicity caused by an organic mercury compound and byp-bromophenylacetylurea in rats. The observations of Yoshinoet al. (1966) on the former intoxication have been confirmed in that an impairment of glycine incorporation into proteins was present in spinal ganglion cells, and may also be taking place in other tissues, before nerve fibre degeneration takes place. A similar reduction in amino acid incorporation into proteins during the period before the onset of paralysis due top-bromophenylacetylurea is found in spinal ganglia; this finding is confirmed by anin vitro method using14C-leucine as protein precursor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00684598
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of60Co radiation on the cellular responses in degenerating dorsal columns in the rat spinal cord (1971)
    Springer
    Acta neuropathologica 19 (1971), S. 318-322 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Co-Radiation ; Spinal Cord ; Rat ; Cell Proliferation ; p-Bromophenylacetylurea
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Rats were irradiated with doses of 1 000–3 000 rads to the cervical spinal cord and subsequently given a paralytic dose of p-Bromophenylacetylurea. The nuclear populations in the degenerating dorsal columns were determined and it was found that a significant suppression of cell proliferation occurred after all three dose levels. The cell populations in the shielded parts of the tracts rostral to the irradiated zone were not affected.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00692152
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
    Digitale Medien
    Digitale Medien
    The effects of methyl-mercury-dicyandiamide on the peripheral nerves and spinal cord of rats (1971)
    Springer
    Acta neuropathologica 19 (1971), S. 208-215 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Organic Mercury ; Neuropathy ; Toxicology ; Neuronal ; Degeneration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Rats have been poisoned with methyl-mercury-dicyandiamide at two different dose levels, 5 mg/kg body weight or 7.5 mg/kg daily for 8 consecutive days. The morphological changes in peripheral nerves and the central nervous system are largely restricted to primary sensory cells of spinal ganglia, and to a lesser extent to the granular cells of the cerebellum. There were clearly two grades of cell damage, either whole cell death or whole fibre death; there is no evidence to suggest that partial fibre death could occur, at least not at the two dose levels used. No definite indications were found for this neuropathy being a ‘dying back’ process, for the nerve fibres appeared to degenerate contemporaneously along their whole extent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00684597
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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