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  • 1
    Electronic Resource
    Electronic Resource
    Interleukin-12 inhibits eosinophil differentiation from bone marrow stem cells in an interferon-γ-dependent manner in a mouse model of asthma (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Intrapulmonary administration of IL-12 has been shown to inhibit the number of eosinophils in lung murine models of asthma, but the precise mechanism of this inhibition has not been reported. The purpose of this study was to examine whether IL-12 treatment inhibits bone marrow eosinophilopoiesis, and to elucidate the role of IFN-γ in this process.Objective  To elucidate the in vivo and in vitro effects of IL-12 on eosinophil differentiation from murine bone marrow (BM) stem cells, and to examine the mechanistic role of IFN-γ in this process.Methods  Allergen-sensitized BALB/c mice were administered low doses of intranasal IL-12 at the time of allergen challenge, and the number of eosinophils in BM was determined 3 days later. The direct actions of IL-12 on eosinophil differentiation from BM cells were determined in vitro. The mechanistic role of IFN-γ was assessed by measuring IFN-γ induction by IL-12 in BM cell cultures, and through the use of IFN-γ KO mice.Results  Treatment of allergic mice with intrapulmonary IL-12 (1 ng or 10 ng) reduced eosinophils in BM by 43%. Culture of BM cells from allergen-sensitized mice with IL-3 + IL-5 induced eosinophil differentiation in vitro. Addition of IL-12 to these cultures inhibited eosinophil differentiation, with maximal inhibition (45%) occurring at 10 ng/mL IL-12 concentration. IL-12 induced IFN-γ production from BM cultures, and failed to inhibit eosinophil differentiation in IFN-γ-knockout mice, indicating a critical mechanistic role for IFN-γ.Conclusion  This study demonstrates that IL-12 selectively inhibits BM eosinophilopoiesis, and that this effect is mediated by IFN-γ. Intrapulmonary IL-12 has suppressive effects on BM eosinophilopoiesis that may represent a novel mechanism contributing to the anti-eosinophilic effects of IL-12 in allergic airway disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0954-7894.2002.01350.x
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental Test of Verwey and Overbeek's Theory (1960)
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 308-309 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The total potential energy V is calculated from the following expression: V = VR + VA (1) where VR and VA are the repulsive and attractive potential energies of interaction of two colloid particles respectively. Derjaguin2 has shown that for small surface potential ^o and large values of xa the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/185308a0
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  • 3
    Electronic Resource
    Electronic Resource
    Dielectric properties of SrTiO3 single crystals subjected to high electric fields and later irradiated with X-rays orγ-rays (1989)
    Springer
    Journal of materials science 24 (1989), S. 3469-3474 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The dielectric constant (K), loss (tanδ), and hence conductivity (σ) of SrTiO3 single crystals have been measured in the frequency region 102–107 Hz and in the temperature range 30°–350° C. Quenching, subjecting the crystals to high electric fields (a.c. or d.c.) and X-ray orγ-ray irradiation, or a combination of these treatments, is found to bring about interesting changes in these properties. An attempt is made to understand the results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02385726
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