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  • 1
    Electronic Resource
    Electronic Resource
    Receptor-mediated uptake and 'retroendocytosis' of high-density lipoproteins by cholesterol-loaded human monocyte-derived macrophages: possible role in enhancing reverse cholesterol transport
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1004 (1989), S. 292-299 
    Details
    ISSN: 0005-2760
    Keywords: (Human macrophage) ; Atherosclerosis ; HDL receptor ; Monocyte-derived macrophage ; Retroendocytosis ; Reverse cholesterol transport
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0005-2760(89)90076-3
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  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-12 inhibits eosinophil differentiation from bone marrow stem cells in an interferon-γ-dependent manner in a mouse model of asthma (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Intrapulmonary administration of IL-12 has been shown to inhibit the number of eosinophils in lung murine models of asthma, but the precise mechanism of this inhibition has not been reported. The purpose of this study was to examine whether IL-12 treatment inhibits bone marrow eosinophilopoiesis, and to elucidate the role of IFN-γ in this process.Objective  To elucidate the in vivo and in vitro effects of IL-12 on eosinophil differentiation from murine bone marrow (BM) stem cells, and to examine the mechanistic role of IFN-γ in this process.Methods  Allergen-sensitized BALB/c mice were administered low doses of intranasal IL-12 at the time of allergen challenge, and the number of eosinophils in BM was determined 3 days later. The direct actions of IL-12 on eosinophil differentiation from BM cells were determined in vitro. The mechanistic role of IFN-γ was assessed by measuring IFN-γ induction by IL-12 in BM cell cultures, and through the use of IFN-γ KO mice.Results  Treatment of allergic mice with intrapulmonary IL-12 (1 ng or 10 ng) reduced eosinophils in BM by 43%. Culture of BM cells from allergen-sensitized mice with IL-3 + IL-5 induced eosinophil differentiation in vitro. Addition of IL-12 to these cultures inhibited eosinophil differentiation, with maximal inhibition (45%) occurring at 10 ng/mL IL-12 concentration. IL-12 induced IFN-γ production from BM cultures, and failed to inhibit eosinophil differentiation in IFN-γ-knockout mice, indicating a critical mechanistic role for IFN-γ.Conclusion  This study demonstrates that IL-12 selectively inhibits BM eosinophilopoiesis, and that this effect is mediated by IFN-γ. Intrapulmonary IL-12 has suppressive effects on BM eosinophilopoiesis that may represent a novel mechanism contributing to the anti-eosinophilic effects of IL-12 in allergic airway disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0954-7894.2002.01350.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of autogenic bacterial antigens on the production of histamine releasing factor by mononuclear cells from intrinsic asthmatic patients (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 43 (1988), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The production of histamine releasing factor (HRF) by mononuclear cells (MNC) from intrinsic asthmatic patients has previously been reported (5). In this study, we investigated the effect of preincubation of lymphocytes with autogenic killed bacteria upon the production of HRF. Bacteria were isolated from the sputum, and nasopharyngeal swab obtained from patients and control subjects. MNC from intrinsic asthmatics and healthy controls were preincubated with killed bacteria for 4 h, then washed and cultured for 18 h. HRF activity of the cell-free supernatants was assayed in the histamine release test using basophils from normal subjects. We found that MNC from the patients spontaneously produce significant amounts of HRF. Preincubation of the cells with autogenic bacterial antigens enhanced HRF production in 12 of 25 patients and only in one of 15 control subjects. No specific bacterial strain was identified as having the sole stimulatory property for HRF production; rather, individual susceptibility predisposes to the ability to produce HRF in response to some common bacteria. When MNC from healthy subjects were preincubated with bacterial antigens isolated from the patients, no enhancement in HRF production was observed. We concluded that MNC from some intrinsic asthmatics are specifically sensitized to certain bacterial antigens and release HRF upon contact with these antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1988.tb01629.x
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  • 4
    Electronic Resource
    Electronic Resource
    Eotaxin but not MCP−3 induces eosinophil influx into nasal fluid in allergic patients (2002)
    Oxford, UK : Munksgaard International Publishers
    Allergy 57 (2002), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Eotaxin and MCP-3 (CC chemokines), owing to their preferential action on eosinophils, seem to be the very importance in the patophysiology of allergic rhinitis and asthma. The purpose of this study was to examine the effect of intranasally administered eotaxin and MCP-3 after specific allergen priming on the influx of inflammatory cells and their soluble mediators into the nasal mucosa.Methods:  Eotaxin and MCP-3 have been applied intranasally at the increasing doses of 1, 5 and 10 µg to allergic patients after allergen priming. The ‘nasal pool’ technique was used. The cell count and biochemical parameters in nasal lavage were evaluated before 30 min, and 4 and 24 h after the challenge with chemokines.Results:  Both eotaxin and MCP-3 induced the increase in clinical ‘score’ lasting till 24 h. Eosinophil influx into nasal mucosa after provocation with eotaxin was also observed. The challenge with MCP-3 did not induce any significant changes in nasal lavage fluid.Conclusions:  Eotaxin is likely to play an important role in the pathogenesis of allergic conditions in humans. MCP-3 did not induce inflammatory cell influx into nasal mucosa. The role of this chemokine in the pathogenesis of allergic inflammation is difficult to assess and requires further studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2002.03555.x
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  • 5
    Electronic Resource
    Electronic Resource
    A Mononuclear Cell-Derived Histamine Releasing Factor in Asthmatic Patients (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In an attempt to study the role of lymphokines in asthma, lymphocytes from asthmatic patients were stimulated in vitro with skin test-positive allergen (dust mite) or with non-specific mitogen-phytohaemagglutinin for 4h, then washed carefully and cultured alone for 16h. Cell-free supernatants were subsequently collected and applied in the basophil histamine release test in vitro and in bronchial provocation test and skin prick test in vivo. Supernatant of non-stimulated lymphocytes from asthmatic patients released significant amounts of histamine from basophils. Stimulation of lymphocytes with specific allergen or phytohamagglutinin augmented the supernatant-induced histamine release. Lymphocyte supernatants from the majority of patients also induced bronchoconstriction and elicited skin wheal and flare reaction in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb02671.x
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  • 6
    Electronic Resource
    Electronic Resource
    Signal transduction mechanisms as new targets for allergists (2001)
    Copenhagen : Munksgaard International Publishers
    Allergy 56 (2001), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2001.056003199.x
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  • 7
    Electronic Resource
    Electronic Resource
    The alleged radioresistance of ameloblastoma: a reply (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01415.x
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  • 8
    Electronic Resource
    Electronic Resource
    Purification of glucoamylase fromAspergillus terreus (1990)
    Springer
    World journal of microbiology and biotechnology 6 (1990), S. 431-433 
    Details
    ISSN: 1573-0972
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Description / Table of Contents: Résumé La glucoamylase d'Aspergillus terreus cultivee sur son de riz a été purifiée par chromatographie sur DEAE-cellulose et sur A-sepharose à concavaline. On a obtenu un monomère homogène après électrophorèse sur SDS-PAGE. L'enzyme est une glycoproténe d'un poids moléculaire de 86,000 avec un contenu en polysacchardie de 7.5% (p/p).
    Notes: Abstract Glucoamylase from a rice bran culture ofAspergillus terreus was purified by chromatography on DEAE-cellulose and concanavatin A-Sepharose. A homogenous monomer resulted after SDS-PAGE electrophoresis. The enzyme was a glycoprotein, molecular weight, 86,000 with 7.5% (w/w) carbohydrate content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01202129
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  • 9
    Electronic Resource
    Electronic Resource
    Enhancement of cholesteryl ester metabolism in cultured human monocyte-derived macrophages by verapamil
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 847 (1985), S. 77-81 
    Details
    ISSN: 0167-4889
    Keywords: (Monocyte-derived macrophage) ; Atherosclerosis ; Calcium channel blockade ; Cholesteryl ester metabolism ; Verapamil
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(85)90155-7
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