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  • 1
    Electronic Resource
    Electronic Resource
    Potentiation by polymyxin B of the bronchoconstriction following allergen inhalation in patients with atopic asthma (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 10 (1980), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of a single inhalation of allergen on bronchial reactivity to polymyxin B was studied in eight patients with hay fever. In winter the reaction to polymyxin B before and after inhalation of pollen allergen is measured by the FEV. In all patients bronchial reactivity to polymyxin B increased under the influence of allergen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1980.tb02159.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of autogenic bacterial antigens on the production of histamine releasing factor by mononuclear cells from intrinsic asthmatic patients (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 43 (1988), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The production of histamine releasing factor (HRF) by mononuclear cells (MNC) from intrinsic asthmatic patients has previously been reported (5). In this study, we investigated the effect of preincubation of lymphocytes with autogenic killed bacteria upon the production of HRF. Bacteria were isolated from the sputum, and nasopharyngeal swab obtained from patients and control subjects. MNC from intrinsic asthmatics and healthy controls were preincubated with killed bacteria for 4 h, then washed and cultured for 18 h. HRF activity of the cell-free supernatants was assayed in the histamine release test using basophils from normal subjects. We found that MNC from the patients spontaneously produce significant amounts of HRF. Preincubation of the cells with autogenic bacterial antigens enhanced HRF production in 12 of 25 patients and only in one of 15 control subjects. No specific bacterial strain was identified as having the sole stimulatory property for HRF production; rather, individual susceptibility predisposes to the ability to produce HRF in response to some common bacteria. When MNC from healthy subjects were preincubated with bacterial antigens isolated from the patients, no enhancement in HRF production was observed. We concluded that MNC from some intrinsic asthmatics are specifically sensitized to certain bacterial antigens and release HRF upon contact with these antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1988.tb01629.x
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  • 3
    Electronic Resource
    Electronic Resource
    Aspirin Tolerance Induced in Aspirin-Sensitive Asthmatics (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 39 (1984), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patients. It was more difficult to achieve tolerance in patients with low ASA-thresholds than in patients with high ones. Daily ASA administration led to prolongation of the refractory state but when the intervals between consecutive doses were increased aspirm hypersensitivity recurred. The pause sufficient for a recurrence of sensitivity to ASA was measured in 16 patients and ranged from 24 h to 9 days Twelve patients challenged with indomethauen after ASA-desensitisation showed good drug tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1984.tb02621.x
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  • 4
    Electronic Resource
    Electronic Resource
    A Mononuclear Cell-Derived Histamine Releasing Factor in Asthmatic Patients (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In an attempt to study the role of lymphokines in asthma, lymphocytes from asthmatic patients were stimulated in vitro with skin test-positive allergen (dust mite) or with non-specific mitogen-phytohaemagglutinin for 4h, then washed carefully and cultured alone for 16h. Cell-free supernatants were subsequently collected and applied in the basophil histamine release test in vitro and in bronchial provocation test and skin prick test in vivo. Supernatant of non-stimulated lymphocytes from asthmatic patients released significant amounts of histamine from basophils. Stimulation of lymphocytes with specific allergen or phytohamagglutinin augmented the supernatant-induced histamine release. Lymphocyte supernatants from the majority of patients also induced bronchoconstriction and elicited skin wheal and flare reaction in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb02671.x
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  • 5
    Electronic Resource
    Electronic Resource
    The Effect of Aspirin during Aspirin “Desensitisation” on Compound 48/80 and Histamine-Induced Skin Responses in Aspirin-Sensitive Asthmatics (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a group of aspirin-sensitive asthmatics we studied skin weal and flare responses to intradermal injections of compound 48/80 and histamine during oral aspirin (ASA) provocation and after ASA “desensitisation”. During provocation (bronchospasm accompanied by naso-ocular symptoms) the mean weal area after compound 48/80 increased to about 42.4% (P 〈 0.05). Neither the threshold (provocative) doses of ASA nor 600 mg ASA, when given after ASA-desensitisation, significantly influenced the weal reactions to compound 48/80 (mean changes of area were –1.8% and –16.5% respectively). Aspirin did not change flare reactions to compound 48/80 and weal and flare reactions to histamine on any of the three study occasions. Initial (pre-aspirin) weal reactions to compound 48/80 after desensitisation to the threshold ASA doses were significantly reduced, but after desensitisation to 600 mg ASA were significantly increased as compared with the reactions before. These data suggest that ASA-“desensitisation” may influence the skin reactivity to non-specific mast cell degranulating stimulus in ASA-sensitive asthmatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb02672.x
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  • 6
    Electronic Resource
    Electronic Resource
    Bronchial and Basophil Reaction to Polymyxin B in Asthmatic Patients (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The hypothesis that increased reactivity to polymyxin B in asthmatic patients is not limited to the bronchi but also exists in basophils was investigated in 26 atopic asthmatic subjects. Quantification of basophil degranulation induced by polymyxin B was performed using a flow-cytometric method. Significant degranulation was noted in 17 patients, but in none of 10 healthy controls. There was close relationship between basophil “releasability” to polymyxin B and bronchial reactivity to inhaled polymyxin B. These findings support the hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb04157.x
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  • 7
    Electronic Resource
    Electronic Resource
    Neutrophil chemotactic activity (NCA) in nasal secretions from atopic and nonatopic subjects (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to elucidate the mechanism responsible for infiltration of nasal mucosa by granulocytes, we tested neutrophil chemotactic activity (NCA) in nasal lavages, by the modified Boyden chamber method, in 16 patients with perennial allergic rhinitis (AR), six ASA-sensitive patients with chronic rhinosinusitis (CRS), and seven normal, nonatopic control subjects (NC). Nasal secretions from all three groups showed significant NCA (mean 157.1±54.0, 62.2±20.7, and 39.4 ± 11.4% of FMLP chemotactic activity for AR, CRS, and NC subjects, respectively). Nasal secretions from patients with AR expressed significantly higher NCA (P〈0.02) than did secretions from NA patients.NCA was unchanged by heating at 56°C for 60 min and was not susceptible to degradation by trypsin. Nasal challenge with Dermatophagoides pteronyssinus antigen induced clinical symptoms and resulted in significant increases in total protein and albumin concentrations in nasal lavages in AR patients, but failed to change the mean NCA activity for up to 40 min after the challenge. These results indicate that nasal secretions from both atopic and nonatopic patients express NCA, but its relation to allergic inflammation remains to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb00738.x
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  • 8
    Electronic Resource
    Electronic Resource
    Pulmonary function and histaminemia after polymyxin B inhalation (1981)
    Springer
    Inflammation research 11 (1981), S. 74-75 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bronchial challenge with polymyxin B caused a significant bronchoconstriction in 85% of atopic asthmatics. In all atopic asthmatics in whom inhalation of polymyxin B elicited bronchoconstriction, a significant, although not always parallel to the grade of bronchoconstriction, increase in histaminemia was observed. If bronchoconstriction was not elicited, the increase in histaminemia did not occur. It constitutes evidence that the bronchoconstricting effect of polymyxin B is exclusively due to degranulation of mast cells and that histamine released in the bronchi can increase the concentration of histamine in the blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991462
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  • 9
    Electronic Resource
    Electronic Resource
    Histaminemia after aspirin challenge in aspirin-sensitive asthmatics (1981)
    Springer
    Inflammation research 11 (1981), S. 105-107 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine the role of mast cells in aspirin-induced bronchoconstriction, venous histaminemia was measured in 17 aspirin-sensitive patients before and after administration of aspirin. Ventilatory disturbances were measured spirographically. Venous histaminemia was determined according to Lorenz. In 11 patients the mean increase of histaminemia was from 39.6 ng/ml to 107.0 ng/ml. In the remaining 6 patients no change in histaminemia was observed after the challenge. In patients exhibiting the increase of histaminemia, symptoms of hypersensitivity to aspirin, other than dyspnea, were more common and stronger. The authors discuss a possible relationship of the aspirin effect, disturbances in prostaglandin synthesis and histamine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991472
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