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Aspirin Tolerance Induced in Aspirin-Sensitive Asthmatics (1984)

Kowalski, M. L. ; Grzelewska-Rzymowska, I. ; Rozniecki, J. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Allergy 39 (1984), S. 0

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ISSN: 1398-9995

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patients. It was more difficult to achieve tolerance in patients with low ASA-thresholds than in patients with high ones. Daily ASA administration led to prolongation of the refractory state but when the intervals between consecutive doses were increased aspirm hypersensitivity recurred. The pause sufficient for a recurrence of sensitivity to ASA was measured in 16 patients and ranged from 24 h to 9 days Twelve patients challenged with indomethauen after ASA-desensitisation showed good drug tolerance.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1398-9995.1984.tb02621.x

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