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  • 1
    Electronic Resource
    Electronic Resource
    Soluble CD8 antigen, stimulated C-peptide and islet cell antibodies are predictors of insulin requirement in newly diagnosed patients with unclassifiable diabetes (1996)
    Springer
    Acta diabetologica 33 (1996), S. 220-224 
    Details
    ISSN: 1432-5233
    Keywords: Key words Unclassifiable diabetes ; Islet cell antibodies ; C-peptide ; Soluble CD8 antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the predictive factors of insulin requirement in newly diagnosed patients with unclassifiable diabetes, 54 consecutive patients, aged less than 35 years, were prospectively followed for 3 years or more. At entry, haemoglobin HbA1c, basal and stimulated C-peptide concentrations, HLA phenotype, islet cell antibodies (ICA) status, and serum levels of soluble CD8 antigen (sCD8) were evaluated. After a median time of 9 (range 2–32) months, 31 patients (group 1) required insulin therapy, whereas 23 patients (group 2) remained non-insulin-requiring after 36 months. Group 1 patients were younger (P〈0.05) and had higher HbA1c and sCD8 serum levels (P〈0.0001, respectively), a higher frequency of ICA positivity and of HLA DR3 and/or DR4 phenotype (P〈0.005 and P〈0.0001, respectively), and lower C-peptide concentrations (P〈0.005 and P〈0.0001, basal and stimulated, respectively) than group 2. The sensitivity, specificity, positive and negative predictive value, and overall accuracy for the subsequent insulin requirement were: sCD8 serum levels (〉737 U/ml), 100%, 65%, 79%, 100% and 85%, respectively; stimulated C-peptide (〈0.60 nmol/l), 71%, 96%, 96%, 74% and 81%, respectively; and ICA positivity (〉20 JDFU), 45%, 91%, 87%, 55% and 65%, respectively. Thus, higher sCD8 serum levels, low stimulated C-peptide concentrations and ICA positivity are the most powerful predictors of subsequent recourse to insulin therapy in young, newly detected patients with unclassifiable diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048547
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Simplified diagnostic criteria for diabetic distal polyneuropathy Preliminary data of a multicentre study in the Campania region (1995)
    Springer
    Acta diabetologica 32 (1995), S. 7-12 
    Details
    ISSN: 1432-5233
    Keywords: Distal polyneuropathy ; Electroneurography ; Diagnostic criteria ; Vibration sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The diagnostic procedures recommended for diabetic neuropathy are rather complex and there is the risk that they may be applied only in highly specialized research centres and not in other more basic health service centres that recruit large numbers of diabetic patients. This consideration highlights the need for rapid and precise diagnostic procedures for the screening and follow-up of diabetic patients. In this paper we describe a simplified diagnostic protocol for distal polyneuropathy (DP), which is the most common form of peripheral neuropathy associated with diabetes. We performed an electronneurographic examination (ENG) based on a five-nerve evaluation in 204 diabetic subjects, and took it as the standard. Its reproducibility preliminarily assessed with a test-retest evaluation was 100%. DP was found in 47 of the 204 diabetic patients on the basis of an alteration in at least two nerves. Other clinical parameters, including a questionnaire on symptoms, a clinical neurological examination (NE), and the vibration perception threshold (VPT) were evaluated. The variability coefficient was not significant for all clinical parameters in a selected group of diabetic patients (questionnaire = 21,2%, NE=5%, VPT=16.5%). The sensitivities and specificities of the questionnaire, NE, and VPT in comparison with ENG were 87% and 60% for the questionnaire, 94% and 92% for NE, and 64% and 97% for VPT, respectively. Thus, the use of ENG permitted the recognition of DP in 14% of patients who were still asymptomatic. Finally, a four-nerve ENG was compared with the five-nerve procedure, and the concordance between the two tests was 100%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581037
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Soluble CD8 antigen, stimulated C-peptide and islet cell antibodies are predictors of insulin requirement in newly diagnosed patients with unclassifiable diabetes (1996)
    Springer
    Acta diabetologica 33 (1996), S. 220-224 
    Details
    ISSN: 1432-5233
    Keywords: Unclassifiable diabetes ; Islet cell antibodies ; C-peptide ; Soluble CD8 antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the predictive factors of insulin requirement in newly diagnosed patients with unclassifiable diabetes, 54 consecutive patients, aged less than 35 years, were prospectively followed for 3 years or more. At entry, haemoglobin HbAlc, basal and stimulated C-peptide concentrations, HLA phenotype, islet cell antibodies (ICA) status, and serum levels of soluble CD8 antigen (sCD8) were evaluated. After a median time of 9 (range 2–32) months, 31 patients (group 1) required insulin therapy, whereas 23 patients (group 2) remained non-insulin-requiring after 36 months. Group 1 patients were younger (P〈0.05) and had higher HbAlc and sCD8 serum levels (P〈0.001, respectively), a higher frequency of ICA positivity and of HLA DR3 and/or DR4 phenotype (P〈0.005 andP〈0.0001, respectively), and lower C-peptide concentrations (P〈0.005 andP〈0.0001, basal and stimulated, respectively) than group 2. The sensitivity, specificity, positive and negative predictive value, and overall accuracy for the subsequent insulin requirement were: sCD8 serum levels (〉737 U/ml), 100%, 65%, 79%, 100% and 85%, respectively; stimulated C-peptide (〈0.60 nmol/l), 71%, 96%, 96%, 74% and 81%, respectively; and ICA positivity (〉20 JDFU), 45%, 91%, 87%, 55% and 65%, respectively. Thus, higher sCD8 serum levels, low stimulated C-peptide concentrations and ICA positivity are the most powerful predictors of subsequent recourse to insulin therapy in young, newly detected patients with unclassifiable diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048547
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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