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  • 1
    Electronic Resource
    Electronic Resource
    Haemophilus influenzae Infections among Hospitalized Adult Patients (2000)
    Springer
    Infection 28 (2000), S. 351-354 
    Details
    ISSN: 1439-0973
    Keywords: Key WordsHaemophilus influenzae ; Adult ; Invasive ; Pneumonia ; Morbidity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Background: Relatively few data are available about Haemophilus influenza (Hi) infection among adults. Materials and Methods: We studied all adult patients with Hi infection hospitalized between 1988 and 1997 at the University Hospital of Berne. Data were abstracted retrospectively from clinical charts and microbiology records using a standardized questionnaire. Results: 12 invasive and 19 noninvasive Hi infections were observed during the study period. The main clinical manifestations were pneumonia (38.7%), bronchitis (29.0%) and meningitis (12.9%). Most patients (71.8%) had underlying condition. Lethality was high (22.6%), especially in pneumonia patients (50%). The frequency of meningitis caused by Hi serotype b (Hib) seemed to decrease after 1990 when conjugated vaccines against Hib were introduced. Conclusion: Hi remains an important cause of lower respiratory and invasive disease associated with high lethality among polymorbid adult patients. The frequency of Hib infections may also decrease in adults due to herd immunity induced by universal vaccination of children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s150100070004
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Meropenem Alone and in Combination with Vancomycin in Experimental Meningitis Caused by a Penicillin-Resistant Pneumococcal Strain (1999)
    Springer
    European journal of clinical microbiology & infectious diseases 18 (1999), S. 866-870 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In a rabbit model of meningitis caused by a pneumococcus highly resistant to penicillin (MIC, 4 μg/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (–0.48±0.14 Δlog10 cfu/ml·h) and slightly superior to ceftriaxone (–0.34±0.23 Δlog10 cfu/ml·h) and vancomycin (–0.39±0.19 Δlog10 cfu/ml·h). Although the combination of vancomycin with ceftriaxone was significantly more active than ceftriaxone alone (–0.55±0.19 Δlog10 cfu/ml·h), only an insignificant gain was observed by the addition of vancomycin to meropenem (–0.55±0.28 Δlog10 cfu/ml·h).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100960050421
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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