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  • 1
    Electronic Resource
    Electronic Resource
    Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: PSORS1 on chromosome 6p21.3, which contains the MHC, is a major susceptibility locus for psoriasis vulgaris. This region is characterized by strong linkage disequilibrium and contains the corneodesmosin (CSDN) gene, an attractive candidate for psoriasis susceptibility based on its putative biological function in keratinocyte adhesion, and HLA-Cw6, an established marker for psoriasis susceptibility. We compared two genetically independent populations in order to define the major psoriasis susceptibility gene, a British Caucasian population comprising parent–offspring trios analysed by the transmission disequilibrium test (TDT) and a Japanese case–control population. All individuals were investigated for CDSN polymorphism (+619, +1236, +1240 and +1243) and HLA-C association. Our data confirms strong association with HLA-Cw6 and CDSN allele 5 (+619T, +1240G, +1243C) in the Caucasian cohort (TDT, P = 5.4 × 10−6) and in addition defines this region further by identifying a high-risk CDSN haplotype (allele 5 and +1236T, P = 8.5 × 10−8). In contrast no association was observed in the Japanese cohort for any HLA-C or CDSN alleles. This data supports a role for the CDSN gene in Caucasian populations with psoriasis. However the lack of association with HLA-Cw6 and CDSN alleles in Japanese psoriasis patients may be because Japanese patients exhibit a form of psoriasis similar to late onset or Type II psoriasis vulgaris in contrast to early onset or Type I disease characterizing our Caucasian population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2005.01789.x
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  • 2
    Electronic Resource
    Electronic Resource
    A Crohn's disease-associated insertion polymorphism (3020insC) in the NOD2 gene is not associated with psoriasis vulgaris, palmo-plantar pustular psoriasis or guttate psoriasis (2003)
    Oxford, UK : Munksgaard International Publishers
    Experimental dermatology 12 (2003), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A C-insertion polymorphism in the NOD2 gene (3020insC) on chromosome 16 is a rare mutation associated with Crohn's disease. Crohn's disease and psoriasis are more commonly observed together than expected by chance. Furthermore a susceptibility locus for psoriasis has been identified on chromosome 16q which overlaps the recently identified susceptibility locus for Crohn's disease. Thus, NOD2 may potentially be important as a candidate susceptibility gene for psoriasis. We tested this hypothesis by genotyping psoriasis patients for the C-insertion polymorphism using the Taqman ABI 7700 sequencing system. No statistically significant differences were observed between psoriasis vulgaris (n = 216), palmo-plantar pustular psoriasis (PPP) (n = 100), guttate psoriasis (n = 118) and the control group (n = 283). In both patient and control groups, no mutant homozygotes were observed and approximately 4% were heterozygotes. This particular insertion mutation in the NOD2 gene does not appear to contribute to the genetic susceptibility of psoriasis vulgaris, PPP or guttate psoriasis. However, other mutations exist in the NOD2 gene, which may potentially have a role in psoriasis susceptibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0625.2002.120420.x
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  • 3
    Electronic Resource
    Electronic Resource
    Membrane kissing (1982)
    [s.l.] : Nature Publishing Group
    Nature 297 (1982), S. 626-627 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CELLS that respond very rapidly to chemical signals such as neurotransmitters change their ionic permeability by altering the functional state of ion channels already present in the membrane. An alternative but improbable way of changing permeability might be to insert patent ion channels into the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/297626a0
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  • 4
    Electronic Resource
    Electronic Resource
    Does intracellular sodium modify membrane permeability to sodium ions? (1977)
    [s.l.] : Nature Publishing Group
    Nature 266 (1977), S. 468-469 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] 14C-amiloride has been used previously to label sodium channels in frog skin and isolated toad bladder cells3,5-7, and the amount of 14C-amiloride displaced from binding sites by un-labelled drug when the former is used at a concentration of 10 nM in the presence of 1.1 mM Na+ is a measure of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/266468a0
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  • 5
    Electronic Resource
    Electronic Resource
    Mechanism of Action of Aldosterone (1969)
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 280-281 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The net transport of sodium across an epithelial membrane is determined by the rate of entry of sodium ions into the cell across the outer, mucosal or tubular surface and by the rate of removal from the cell by an ion pump situated on the inner or serosal surface. Sodium transport can therefore be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/222280a0
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  • 6
    Electronic Resource
    Electronic Resource
    Electrical Activity of a Mammalian Vein (1964)
    [s.l.] : Nature Publishing Group
    Nature 202 (1964), S. 95-95 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Spirals, 2 cm in length, were cut from the anterior mesenteric veins of freshlykilled rabbits and mounted in a sucrose gap electrode1. Arrangements were made, using an R..C.A. 5734 mechano-electronic transducer, to record isotonic contractions of the strip simultaneously with electrical activity. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/202095a0
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  • 7
    Electronic Resource
    Electronic Resource
    Fertilization acid production in Psammechinus eggs under pH clamp conditions, and the effects of some pyrazine derivatives
    Amsterdam : Elsevier
    Experimental Cell Research 114 (1978), S. 409-415 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(78)90500-1
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  • 8
    Electronic Resource
    Electronic Resource
    Similarities between sodium channels in excitable membranes and in epithelia (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 1321-1323 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The inhibitory effects of the pyrazine derivative, amiloride, on sodium transport in an amphibian epithelium has been studied as a function of pH. It is concluded that the charged (guanidinium) group interacts with a negatively charged acid grouping in the membrane. Similarities between sodium channels in excitable membranes and epithelia are highlighted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953117
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  • 9
    Electronic Resource
    Electronic Resource
    Amiloride and the sodium channel (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 261-269 
    Details
    ISSN: 1432-1912
    Keywords: Amiloride ; Triamterene ; Sodium Channel ; Antidiuretic Hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amiloride and the sodium channel. The diuretic drugs amiloride and triamterene have been used as probes for sodium channels in the mucosal surface of isolated frog skin. Both substances interact competitively with sodium for the channel. Using 14C-amiloride measurements were made of the number of channels present in the mucosal surface under a variety of conditions. The data suggests that a reliable estimate of sodium channel density can be made. Antidiuretic hormone applied to the serosal surface was found to have no effect on the numbers of channels, while the current passing through each channel was increased. The implications of these findings for the mechanism by which hormone alters the mucosal sodium permeability are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500595
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  • 10
    Electronic Resource
    Electronic Resource
    Antisecretory activity of the alpha2-adrenoceptor agonist, xylazine in rat jejunal epithelium (1989)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 339 (1989), S. 669-674 
    Details
    ISSN: 1432-1912
    Keywords: Alpha2-adrenoceptors ; Forskolin ; Vaso-active intestinal polypeptide intestinal polypeptide ; Substance P ; Gastrointestinal epithelia epithelia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Xylazine, an α2 adrenoceptor agonist, reduces short circuit current (SCC) in epithelial preparatior of rat jejunum. The α2 antagonist yohimbine, abolishe this response while prazosin was without effect The cyclooxygenase inhibitor, piroxicam, also attenuate xylazine responses indicating that the antisecretory effect were dependent upon endogenous eicosanoid formation. the secretory state of piroxicam treated tissues was restore by addition of either forskolin, vasoactive intestinal poll peptide (VIP), prostaglandin E2 (PGE2) or isobutyl-: methyl-xanthine (IBMX) then subsequent additions of xylazine were effective in reducing SCC. All these agents are known to increase SCC and cause Cl secretion by elevating intracellular cAMP. In addition, xylazine was also able to inhibit the Ca2+-mediated secretory responses of carbachol (CCh) and substance P (SP) in rat jejunum. This ability of xylazine to inhibit CAMP- and Ca2+-mediated secretion may indicate that α2 adrenoceptors interact with more than or type of G protein or alternatively suggests a more general interaction between second messenger systems withiin epithelia of the small intestine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168660
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