ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
3-α-Bromacetyl-coumarines as Synthones for Heterocyclic Substituted Coumarines3-α-Bromacetyl-coumarines 2 react easily and in high yields with thiourea and thioamide derivatives 3 and 5, resp., to 4-coumar-3′-yl-thiazoles 4 and 6, resp., as well as with N,N-disubstituted thioamides 11 and N,N,N′,N′-tetraalkylthiourea 12 to 5-coumar-3′-yl-oxathioliumsalts 13 and 14, respectively. In a two-step reaction 2 can be transformed by reaction with aniline 17 to 4-coumar-3′-yl-imidazoles 21 and 5-coumar-3′-yl-oxazoliumsalts 22, resp., via aminoketone intermediates 18.
Additional Material:
7 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19833250405
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