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  • 1
    Electronic Resource
    Electronic Resource
    Adjuvant Vaccination in Colorectal Carcinoma (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 690 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb44031.x
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  • 2
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Frage der medikamentösen Beeinflussung der peripheren Symptomatik thyreotoxischer Krisen (1966)
    Springer
    Langenbeck's archives of surgery 316 (1966), S. 594-597 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433685
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  • 3
    Electronic Resource
    Electronic Resource
    Das Schilddrüsenadenom Jugendlicher (1968)
    Springer
    Langenbeck's archives of surgery 322 (1968), S. 1218-1222 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bericht über 475 Strumen bei Jugendlichen, die innerhalb von 11 Jahren zur Beobachtung kamen. Unter diesen waren 19 (=4%) Carcinome. Auf die Sonderstellung der Solitäradenome bei Jugendlichen −10 Carcinome unter 47 Solitäradenomen (=21%) — wird hingewiesen. Die Prognose ist günstig. Operationsmethoden und Nachbehadlung werden besprochen. Abschließend wird auf die Rezidivneigung jugendlicher Strumapatienten −50% nachFuchsig u.Kummer — hingewiesen. An Hand von Tierexperimenten und klinischen Befunden wird gezeigt, daß die vierfache Ligatur — in Form der Stammligatur aller 4 Schilddrüsenarterien-keinen Einfluß auf die Rezidivbildung hat.
    Notes: Summary This is report on 475 adolescent goitres which were observed during the past 11 years. Amongst them were 19(=4%) carcinomas. The special place which solitary adenomas in adolescents occupy is demonstrated by the fact that there were amongst 46 solitary adenomas 10 carcinomas (=21%). The prognosis is good. Surgical methods and postoperative treatment are discussed. In conclusion the tendency towards relapses amongst adolescent goitre patients (50% according toFuchsig andKummer) is mentioned. It is shown with the aid of animal experiments and clinicla reports that the fourfold ligature, in the form of a trunk ligature of all four thyroidal arteries, has no effect on the incidence of relapses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02454032
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative analysis of cancer-associated antigen CA-195, CA19-9 and carcinoembryonic antigen in diagnosis, follow-up and monitoring of response to chemotherapy in patients with gastrointestinal cancer (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 493-496 
    Details
    ISSN: 1432-1335
    Keywords: Cancer-associated antigen CA-195 ; Carcinoembryonic antigen ; CA19-9 ; Gastrointestinal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To establish further the clinical significance of the CA-195 tandem immunoradiometric assay in gastrointestinal malignancies, the sera of a total of 222 subjects have been analysed and compared with assays of the “classical gastrointestinal tumour markers”, CA19-9 and carcinoembryonic antigen (CEA). CA-195 elevations above normal (〉10 U/ml) were noted in 51/72 (70.8%) colorectal, 15/15 (100%) pancreatic, and in 6/12 (50%) gastric cancer patients. Whereas CA19-9 was increased (〉37 U/ml) in 65%, 93%, and 42% of cases, only 54% colorectal, 45% pancreatic, and 42% gastric cancer patients had pathologically elevated serum CEA levels (〉5 ng/ml). No abnormal increase of both CA-195 and CA19-9 was found in healthy volunteers, whereas 3/20 (smoking) individuals had CEA levels slightly above normal. With a 29% false-positive rate noted among 103 patients with benign gastroinestinal disorders, the specifity of CA-195 was superior to that of CA19-9 (58%) and comparable with that of CEA (31%). A significant correlation between CA-195 levels and the clinical/pathological stage of disease was noted in colorectal (P〈0.01) and pancreatic cancer patients (P〈0.007). Preliminary results of serial measurements of CA-195 in colorectal cancer suggest that this new marker protein, which has no cross-reactivity with CEA, may be useful as a non-invasive test for postoperative surveillance of patients to detect disease recurrence, and serve to complement (though certainly not replace) standard clinical measurements of response to chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01612773
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative analysis of CA72-4, CA195 and carcinoembryonic antigen in patients with gastrointestinal malignancies (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 318-320 
    Details
    ISSN: 1432-1335
    Keywords: Gastrointestinal malignancies ; CA72-4 ; CA195 ; CEA ; Tumour marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To establish further the clinical significance of the novel quantitative immunoradiometric assay system CA72-4 in patients with gastric and other digestive tract malignancies, the sera of a total of 208 subjects have been analysed and levels of carcinoembryonic antigen (CEA) and another promising new tumour marker, CA195, have been compared. Twenty patients had gastric (GC), 60 colorectal (CC), and 14 pancreatic carcinomas (CC); 94 patients had benign disorders, and 20 were healthy volunteers. CA72-4 elevations above normal (〉4 U/ml) were observed in 6 (30%) GC, 17 (28%) CC, and 8 (57%) PC patients. CA195 appeared more sensitive and was increased (〉10 U/ml) in 35% GC, 70% CC, and in 100% PC patients; CEA levels above normal (〉5 ng/ml) were noted in 35%, 45%, and 66% of patients respectively. CA72-4 had a rather high specificity and was increased in only 6/94 (6%) patients with benign diseases, whereas CA195 had a false positive rate of 23%, and CEA of 33%. Among 20 healthy donors, none had elevated levels of CA72-4 or CA195, but marginal elevations of CEA were noted in 3 smokers. Despite some advantage of the new tumour marker CA72-4 in terms of specificity, its value as a serodiagnostic test in gastrointestinal cancer patients seems inferior to that of CA195 and CEA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208623
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  • 6
    Electronic Resource
    Electronic Resource
    Phase II study of amonafide in advanced breast cancer (1991)
    Springer
    Breast cancer research and treatment 20 (1991), S. 63-67 
    Details
    ISSN: 1573-7217
    Keywords: amonafide ; advanced breast cancer ; chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-eight patients with advanced breast cancer refractory to prior hormone and/or first-line chemotherapy (with or without anthracycline drugs) were treated with the investigational agent amonafide at a dose of 800 mg/m2 intravenously over 3 hours repeated every 4 weeks. Five objective tumour responses of 5.0 months' median duration were observed in the 20 patients without previous anthracycline exposure, including 1 CR. Leukopenia was the dose-limiting toxicity; though it was generally modest with the 800 mg/m2 amonafide starting dose, an initial dose reduction should be considered in patients with prior radiotherapy and/or bone marrow involvement. Other adverse reactions included nausea/vomiting (53%), phlebitis/erythema along the vein injected (7%), and mild neurotoxic symptoms during the drug administration such as headache, tinnitus, and diaphoresis (21%). Amonafide is an active compound for the treatment of patients with advanced breast cancer and should be considered for further evaluation and incorporation in combination chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01833358
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  • 7
    Electronic Resource
    Electronic Resource
    42. Die Lebenserwartung des Schilddrüsencarcinonis im Kindesalter (1971)
    Springer
    Langenbeck's archives of surgery 329 (1971), S. 154-155 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bericht über 19 Carcinome der Thyreoidea im Kindesalter aus dem eigenen Kollektiv von 501 lückenlos nachuntersuchten Schilddrüsen-carcinomen. Unter den 19 Fällen war kein einziger Fall eines undifferenzierten Carcinoms. Es haben die sog. potentiell malignen Formen, neben den papillären Carcinomen und organoiden Carcinomen vom Typ der Langhans Struma überwogen. Dieser Eigenart ist es auch zuzuschreiben, daß jugendliche Schilddrüsen-carcinome eine äußerst gute Prognose haben. Alle Patienten überlebten 5 Jahre rezidivfrei, die längste Beobachtungszeit beträgt 14 Jahre und 6 Monate. Folgender Therapieplan wurde ausgearbeitet: Bei den sogenannten „potentiell malignen Formen”, die durch eine Kapsel-infiltration oder einen Venoleneinbruch gekennzeichnet sind, wird die Lobektomie der erkrankten Seite mit möglichst ausgedehnter Resektion der kontralateralen Seite ausgeführt, um eine bessere Voraussetzung für die nachfolgende Strahlentherapie zu schaffen. Bei allen anderen Formen führen wir die erweiterte Radikaloperation im Sinne einer Radikal-Neck-Dissection durch. Neben der Operation ist die Strahlentherapie in Form der Radiojod- oder Hochvolttherapie zusammen mit einer lebenslangen Schilddrüsenhormontherapie die wichtigste Maßnahme.
    Notes: Summary Report on 19 carcinomas of the thyroid in children out of a personal series of 501 consecutive and carefully observed cases of thyroid carcinoma. Amongst the 19 cases there was not a single case of indifferentiated carcinoma. The so-called potentially malignant forms, in addition to papillar carcinomas and organoid carcinomas of the Langhans Strums type, predominated. It is due to this predominance of these forms that the juvenile thyroid carcinomas have an extremely good prognosis. All our patients survived the first 5 years and the longest period of observation extends to 14 years and 6 months. The following plan of therapy has been developed: In the so-called “potentially malignant forms” which are distinguished by infiltration of the capsule and breaking into venules, a lobectomy of the affected side together with a fairly extensive resection of the contralateral side is carried out, to provide suitable conditions for the subsequent radiation therapy. In all other forms an extended radical operation in the sense of a radical-neck-dissection was carried out. In addition to the operation, the radiation therapy in the form of a radio-iodine or high voltage therapy and the lifelong medication with thyroid hormone are the most important measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01770456
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  • 8
    Electronic Resource
    Electronic Resource
    105. Der Dickdarmschleimhautpolyp als Begleitbefund beim Colon- und Rectumcarcinom (1976)
    Springer
    Langenbeck's archives of surgery 342 (1976), S. 576-576 
    Details
    ISSN: 1435-2451
    Keywords: Carcinoma, colorectal, intestinal ; Polyp, colorectal, intestinal ; Dickdarmschleimhautpolyp und Carcinom ; Dickdarmearcinome und Polypen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 143 Polypen aus den Resektionspräparaten von 123 Patienten mit Colon- oder Rectumcarcinom (Gruppe A) wurden untersucht. Es erfolgte ein histologischer Vergleich mit 117 Polypen malignomfreier Patienten (Gruppe B). Das Carcinoma in situ war in Gruppe A signifikant häufiger (14% in A, 6,8% in B). Nicht signifikant war die Differenz an Polypen mit invasivem Carcinom. Polypen mit malignem Befund der Gruppe B waren durchschnittlich 2/Z mal so groß wie die der Gruppe A. 74% aller Polypen der Gruppe A lagen innerhalb einer 6 cm breiten Zone beidseits des Carcinoms.
    Notes: Summary The pathological specimens taken from 123 patients with colorectal carcinoma (Group A) included 143 polyps. These were compared histologically with 117 polyps taken from patients who did not have carcinoma of the large bowel (Group B). The incidence of carcinoma in situ was significantly higher in Group A (14% as against 6.8% in Group B). The difference in the incidence of invasive carcinoma between the two groups was not significant. The malignant polyps found in Group B were on average two-and-a-half times the size of those in Group A. Of the polyps taken from patients in Group A, 74 percent were located within 6 cm of the carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01267452
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  • 9
    Electronic Resource
    Electronic Resource
    Beurteilung des peripheren arteriellen Widerstandes durch Perfusionsdruckmessung im Tierexperiment (1968)
    Springer
    Langenbeck's archives of surgery 320 (1968), S. 362-366 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Mit Hilfe eines einfachen Meßverfahrens ist es möglich, im Tierexperiment intraoperativ den peripheren Gefäßwiderstand zu bestimmen. Durch diese direkte Bestimmung des Widerstandes der peripheren Strombahn wird es möglich sein, die Erfolgschancen einer Gefäßoperation exakter als bisher abzuschätzen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01443755
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  • 10
    Electronic Resource
    Electronic Resource
    Effective second line chemotherapy of advanced breast cancer with navelbine and mitomycin C (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. 49-53 
    Details
    ISSN: 1573-7217
    Keywords: advanced breast cancer ; second-line treatment ; navelbine ; mitomycin C
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The efficacy and toxicity of navelbine 30 mg/m2 administered intravenously (IV) over 30 minutes every 3 weeks, and mitomycin C 15 mg/m2 administered IV every 6 weeks was assessed in 34 patients with metastatic breast cancer refractory to first-line chemotherapy. An overall objective response rate of 35% was achieved (95% confidence interval, 20% to 53%), with an additional 47% of patients maintaining stable disease (SD). Four of 12 patients who responded had received previous anthracycline therapy. Median time to progression for responders and patients with SD was 6.3 months. The median survival of all patients was 8.8 months. Tolerance of this regimen was remarkable. WHO grade 3/4 side effects consisted of granulocytopenia in 12% and thrombocytopenia in 15%, and included only 1 patient each with grade 3 neurotoxicity and local toxicity due to extravasation. Delay of treatment was required for hematologic toxicity in 7 patients, and 5 required dose reductions. In conclusion, navelbine/mitomycin C is an active and well-tolerated regimen that may be considered for second-line treatment. If our results are confirmed by larger analyses of other patient studies, this combination might also warrant further exploration in combination with other active agents for front line chemotherapy of advanced breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00682699
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