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  • 1
    ISSN: 1432-2013
    Keywords: Renal hypertension ; Control of peripheral resistance ; Distribution of cardiac output ; Particle distribution method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The regional distribution of the peripheral vascular resistance was studied in normotensive and hypertensive Wistar rats. Two models of experimental hypertension were investigated: (I) in 32 animals the right renal artery was constricted by a silver clip (two-kidney Goldblatt hypertension); (II) in 46 animals the left kidney was removed and the right renal artery was clipped as in the first group (one-kidney Goldblatt hypertension). The normotensive control group comprised 61 untreated animals of the same strain and age. The distribution of cardiac output to 14 tissues was determined by means of the particle distribution technique. The resistance was increased in all regions investigated, a decreased or unchanged resistance was not observed. For most of the investigated tissues the regional resistance was increased exactly in proportion to the total peripheral resistance (TPR). Exceptions to this were found in 2 regions where the change of local resistance deviated from that of TPR: the splanchnic area and the skeletal muscle. In both cases the 2 models differed from each other. In the two-kidney model the increase of resistance in the splanchnic circulation was more intense than in other organs. In contrast, in the one-kidney model the local change of resistance was less than that of TPR. The change of rkeletal muscle resistance was not significantly different from the change of TPR in the two-kidney model, while in the one-kidney model the increase of local resistance was significantly higher than that of TPR. It is concluded that the etiology of the abnormal resistance is different in the 2 models investigated and that known extrinsinc pressor factors may play a role in the two-kidney, but not in the one-kidney Goldblatt hypertension.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 186 (1973), S. 181-190 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Über Größe und Regulation der Durchblutung des Auges und seiner einzelnen Kreislaufcompartments liegen aus methodischen Gründen bisher kaum zuverlässige Daten vor. Die Partikelverteilungsmethode wird deshalb dazu benutzt, am Katzen- und Hundeauge die Durchblutungsgröße quantitativ zu bestimmen. Ergebnisse: 1. Katzen. Bei einem mittleren arteriellen Druck von 138 mm Hg, einem Herzzeitvolumen von 274,0 ml/min wurde eine mittlere Augendurchblutung von 1,1 ml/min gemessen (n=8). Die Durchblutungsgröße lag zwischen 0,36 ml/min bei einem PaCO2 von 22 mm Hg und 2,30 ml/min bei einem PaCO2 von 42 mm Hg. 2. Hunde. Bei einem mittleren arteriellen Druck von 90 mm Hg, einem Herzzeitvolumen von 1380,0 ml/min ergab sich eine mittlere Durchblutung des Gesamtauges von 0,86 ml/min (auf der Seite der Carotisligatur) bzw. 1,20 ml/min (auf der contralateralen Seite) (n=7). Die Durchblutungsgröße lag zwischen 0,30 ml/min bei einem PaCO2 von 28 mm Hg und 1,86 ml/min bei einem PaCO2 von 42 mm Hg. Die Durchblutung der tunica externa betrug durchschnittlich 4,3 ml/100 g min, der uvea und retina 209,8 ml/100 g min. Die Augendurchblutung zeigt eine deutliche Abhängigkeit vom arteriellen Kohlensäurepartialdruck.
    Notes: Summary Up to now there are very few data available about the flow volume and regulating mechanism of the blood circulation in the eye and its individual circulation compartments, which might be due to the methods used. In our investigations the particle distribution method was tested as a means for quantitative measurements of the flow volume, and was applied to the eyes of cats and dogs. Results: 1. Cats. At a mean arterial pressure of 138 mm Hg, and a cardiac output of 274.0 ml/min, mean blood circulation in the eye was between 1.1 ml/min (n=8). Flow volume was 0.36 ml/min with PaCO2 being 22 mm Hg, and 2.30 ml/min with PaCO2 being 42 mm Hg. 2. Dogs. At a mean arterial pressure of 90 mm Hg, and a cardiac output of 1380.0 ml/min, mean circulation in the whole globe was 0.86 ml/min (at the side of the carotid ligature) and 1.20 ml/min (at the contralateral side) respectively (n=7). Flow volume measured was 0.30 ml/min with PaCO2 being 28 mm Hg and 1.86 ml/min with PaCO2 being 42 mm Hg. Measurements of the circulation in the tunica externa gave a mean value of 4.3 ml/100 g min, those of uvea and retina 209.8 ml/100 g min. Blood flow in the eye shows a significant dependence on the arterial CO2 partial pressure.
    Type of Medium: Electronic Resource
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