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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 58 (1992), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of unilateral labyrinthectomy followed by the process of vestibular compensation on the incorporation of radioactive phosphate into frog brain proteins was investigated. Phosphoproteins were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by autoradiography. The present data show that unilateral labyrinthectomy affects the incorporation of 32P into various frog brain proteins. In particular, the phosphorylation of a 20-kDa protein appeared enhanced during early stages of vestibular compensation (4–12 days). This 20-kDa protein was shown to be immunologically related to myelin basic protein and its phosphorylation was regulated by an endogenous calcium/calmodulin-dependent protein kinase. These data might indicate that in addition to neuronal components, components of glial origin are also involved in biochemical events that lead to functional recovery after neuronal lesions.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Social and Biological Systems 8 (1985), S. 395-399 
    ISSN: 0140-1750
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 22 (1988), S. 65 
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2013
    Keywords: Renal hypertension ; Control of peripheral resistance ; Distribution of cardiac output ; Particle distribution method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The regional distribution of the peripheral vascular resistance was studied in normotensive and hypertensive Wistar rats. Two models of experimental hypertension were investigated: (I) in 32 animals the right renal artery was constricted by a silver clip (two-kidney Goldblatt hypertension); (II) in 46 animals the left kidney was removed and the right renal artery was clipped as in the first group (one-kidney Goldblatt hypertension). The normotensive control group comprised 61 untreated animals of the same strain and age. The distribution of cardiac output to 14 tissues was determined by means of the particle distribution technique. The resistance was increased in all regions investigated, a decreased or unchanged resistance was not observed. For most of the investigated tissues the regional resistance was increased exactly in proportion to the total peripheral resistance (TPR). Exceptions to this were found in 2 regions where the change of local resistance deviated from that of TPR: the splanchnic area and the skeletal muscle. In both cases the 2 models differed from each other. In the two-kidney model the increase of resistance in the splanchnic circulation was more intense than in other organs. In contrast, in the one-kidney model the local change of resistance was less than that of TPR. The change of rkeletal muscle resistance was not significantly different from the change of TPR in the two-kidney model, while in the one-kidney model the increase of local resistance was significantly higher than that of TPR. It is concluded that the etiology of the abnormal resistance is different in the 2 models investigated and that known extrinsinc pressor factors may play a role in the two-kidney, but not in the one-kidney Goldblatt hypertension.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 45 (1967), S. 322-323 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Lung scanning with J131 labelled macroaggregated serumalbumin has been shown to be a suitable indicator of regional pulmonary blood flow. According to v.Euler u.Lilljestrand the alveolar gas tensions are the important parameters regulating the distribution of pulmonary blood flow. It can be demonstrated that changes of alveolar air composition are combined with characteristic changes in the distribution pattern obtained by lung scanning. Dogs, under general nembutal anesthesia, were intubated with Carlens catether. One lung was eliminated from gas exchange by rebreathing, the opposite side was ventilated with ambient air. Lung scan performed after reaching a steadystate shows a widely reduced storage of the incorporated albumin aggregates at the rebreathing side, at the normally ventilated lung storage is increased. The relation of storage rates under these experimental conditions was 1:2,5. The significance of these observations for the interpretation of clinical findings is discussed.
    Notes: Zusammenfassung Das Lungenszintigramm mit J131-markierten Albuminaggregaten ermöglicht eine Beurteilung der regionären Durchblutungsgrößen im Bereich des Pulmonalkreislaufs. Nach v.Euler undLilljestrand u.a. sind die lokalen alveolären Gasspannungen der entscheidende Steuerungsfaktor für die Verteilung der pulmonalen Durchblutung. In der vorliegenden Untersuchung wird nachgewiesen, daß regionäre Störungen des Gasaustauschs sich in charakteristischer Weise im Lungenszintigramm äußern. An Nembutalnarkotisierten Hunden wurde durch Intubation mit einem Carlens-Katheter die Möglichkeit geschaffen, beide Lungen mit verschiedenen Gasgemischen zu beatmen. Auf der einen Seite wurde eine Rückbeatmung bis zum Erreichen eines steady-state durchgeführt, die andere Seite wurde mit Frischluft ventiliert. Die anschließend durchgeführte Lungenszintigraphie zeigt, daß die Speicherung der inkorporierten Partikel über der ausgeschalteten Lunge herabgesetzt, über der normal atmenden Lunge vermehrt ist. Das Verhältnis der Speicherungsraten beträgt bei dieser Versuchsanordnung im Mittel 1:2,5. Die Bedeutung dieser Beobachtungen für die Interpretation klinischer Befunde wird diskutiert.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 111 (1996), S. 139-143 
    ISSN: 1432-1106
    Keywords: Eye movements ; Saccadic reaction time ; Express saccades ; Presaccadic potentials ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When a temporal gap is introduced between the offset of the central fixation point and the appearance of a new target, saccadic reaction time is reduced (gap effect) and a special population of extremely fast saccades occurs (express saccades). It has been hypothesized that the gap triggers a readiness signal, which is responsible for the reduced saccadic reaction times. Here we recorded event-related potentials during the gap to in vestigate the central processes associated with the gener ation of fast regular saccades and express saccades. Prior to the execution of fast regular saccades, subjects pro duced a slow negative shift, with a maximum at frontal and central channels that started 40 ms after fixation offset. This widespread negativity is similar to a readiness potential. Anticipatory saccades were preceded by an increased frontal and parietal negativity. Prior to express saccades, a frontal negativity was observed, which started 135 ms after the disappearance of the fixation point. It is assumed that the frontal negativity prior to express saccades corresponds to the fixation-disengagement dis charge described in the frontal eye field of monkeys. Therefore, we hypothesize that fast regular saccades are the result of an increased readiness signal, while express saccades are the result of specific preparatory processes.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 111 (1996), S. 289-295 
    ISSN: 1432-1106
    Keywords: Schizophrenia ; Eye movements ; Saccades ; Prefrontal cortex ; Working memory ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, the execution of delayed saccades in 15 DSM-III-R-schizophrenic patients and 15 normal subjects was investigated. While looking at a central fixation cross, a peripheral target was randomly presented at 10° eccentricity. Subjects were instructed to saccade to the target when the fixation cross was switched off after 500 ms. Two experiments were conducted: (a) a delayed-saccade task and, (b) a memoryguided saccade task, that is, the peripheral target was switched off together with the fixation cross. In the delayed-saccade task, amplitudes of regular saccades did not differ between schizophrenic patients and normals. In the memory-guided saccade task, schizophrenic subjects showed marked hypometric saccades. Incorrect delayed saccades (while the fixation cross was on) were also hypometric in schizophrenics, but not in normal controls. The final eye position, i.e., the position reached after the execution of correction saccades, however, did not differ between patients and controls. This means that schizophrenics show a deficit in the programming of primary saccades, if the fixation point and the peripheral target are (a) both visually presented or (b) both memorized. The results support the hypothesis that these saccades are the result of an averaging effect between the fixation point and the peripheral target. It is further hypothesized that these deficits might be explained by a lack of prefrontal inhibition of ocular fixation areas.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 115 (1997), S. 479-484 
    ISSN: 1432-1106
    Keywords: Key words Saccadic reaction time ; Eye movements ; Event-related potentials ; Slow waves ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Saccades elicited by suddenly appearing targets show a broad distribution of reaction times. This may depend on variations in the subject’s state of preparation before target onset. To test this hypothesis, we recorded scalp event-related potentials from eight human subjects to investigate whether differences in saccadic reaction times (SRTs) are related to differences in cortical slow potentials prior to target onset. Compared with trials with medium SRTs (180–230 ms), trials with fast SRTs (130–180 ms) were found to be preceded by a more negative slow potential and trials with slow SRTs (230–280 ms) were found to be preceded by a more positive slow potential. These results support the hypothesis that cortical activation prior to target appearance influences SRTs.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1224-1226 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es wird ein Verfahren zur autoradiographischen Darstellung der intramyocardialen Durchblutungsverteilung nach experimenteller Coronarocclusion angegeben. Im Versorgungsbereich akut verschlossener Coronararterien wird eine inhomogene Reduktion der Durchblutung beobachtet, wobei die Innenschichten regelmässig stärker als die subepicardialen Myocardanteile betroffen sind.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 25 (1969), S. 779-780 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es wird ein autoradiographisches Verfahren zur Bestimmung der regionalen Durchblutungsverteilung in differenziert strukturierten Organen beschrieben. Mit dieser neuen Methode wird die Durchblutung der Nierenrinde untersucht. Es wird nachgewiesen, dass die Durchblutungs- bzw. Widerstandsverteilung innerhalb der Rinde nicht einheitlich ist, sondern dass sich drei verschieden durchblutete, anatomisch voneinander abgrenzbare Teile unterscheiden lassen.
    Type of Medium: Electronic Resource
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