ISSN:
1433-2981
Keywords:
Key words:Agnogenic myeloid metaplasia – Bone marrow – Chronic myeloproliferative disorder – Enzyme histochemistry – Idiopathic myelofibrosis – Immunohistochemistry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract: Idiopathic myelofibrosis (IMF) in an 8-year-old cat and in three dogs, aged 4, 8 and 3 years, respectively, is discussed. Haematologically, the prefibrotic IMF of the FeLV (feline leukaemia virus)-positive cat exhibited an aleukaemic pattern of development with thrombocytosis; gross-pathologically, it exhibited a splenomegaly, and histologically, abnormal (polymorphic) medullary megakaryocytopoiesis and increased neutrophilic granulocytopoiesis with neoplastic bilinear extramedullary haematopoiesis (myeloid metaplasia, MM) in the spleen and liver. Haematologically, the canine IMFs exhibited anaemia, with white blood cell values ranging between leucocytosis and leucopenia, and thrombocyte values from the normal range to thrombocytopenia. Gross-pathologically, they exhibited hepatosplenomegaly, and histologically, a medullary proliferation of abnormal (polymorphic) megakaryocytes with conspicuous concentration in clusters, reticulin fibrosis and, in two cases, the occurrence of distended sinusoids with intravascular haematopoiesis. Extramedullary neoplastic haematopoiesis (MM) was found in the spleen and liver in particular. From the differential diagnostic perspective, the following morphological criteria are particularly relevant: largely mature, polymorphic megakaryocytes, distended bone marrow sinusoids, only a small number of blast cells in the bone marrow, MM of the spleen and liver.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00010002
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