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  • 1
    Electronic Resource
    Electronic Resource
    Secondary structure of the complement control protein module by two-dimensional proton NMR (1991)
    s.l. : American Chemical Society
    Biochemistry 30 (1991), S. 997-1004 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00218a016
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lipidstoffwechsel normaler und atherosklerotisch veränderter Intima in menschlichen Femoralarterien (1973)
    Springer
    Virchows Archiv 361 (1973), S. 71-75 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aufnahme und Einbau von 14C-Ölsäure in Phospholipide, Triglyzeride und Cholesterin-Ester von Fettstreifen (fatty streaks) und Atheromen (fibrofatty lesion) in menschlichen Femoralarterien wurde untersucht und mit Aufnahme und Einbau in die genannten Lipidfraktionen in benachbarten normalen Intima-Bezirken und in die Media derselben Arterien verglichen. In Fettstreifen kommt es zu einem vermehrten Einbau von 14C-Ölsäure in Triglyzeride und Phospholipide im Vergleich zu der benachbarten normalen Intima und der darunter liegenden Media. Der Einbau in Cholesterin-Ester ist besonders hoch in Fettstreifen (ungefähr 20mal) verglichen mit der angrenzenden normalen Intima. Andererseits ist der vermehrte Einbau von Ölsäure in die drei Lipidfraktionen bei Atheromen nicht sehr ausgeprägt. Die Bedeutung des Lipidstoffwechsels in der Entstehung der frühen menschlichen atherosklerotischen Veränderungen wird diskutiert.
    Notes: Summary The uptake and incorporation of (1-14C)-oleic acid into phospholipid, triglyceride and cholesterol ester by fatty streak and fibro fatty lesions in human femoral arteries was investigated and compared with the uptake and incorporation into these lipid fractions in normal intima and media in the same arteries. In fatty streak lesions, increased incorporation of (1-14C)-oleic acid into triglyceride and phospholipid occured in relation to the adjacent normal intima and media. Incorporation into cholesterol ester is particularly high (approximately 20 times) in fatty streak lesions compared with the adjacent normal intima. On the other hand, increased incorporation of oleic acid into the three lipid fractions is not marked in the fibro fatty lesion. The significance of metabolism of lipid in the pathogenesis of the early human lesions is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543551
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  • 3
    Electronic Resource
    Electronic Resource
    Allozyme variation in populations of the dog-whelkNucella lapillus (Prosobranchia: Muricacea) from the South West peninsula of England (1988)
    Springer
    Marine biology 99 (1988), S. 93-100 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Four populations of the predatory gastropodNucella lapillus were sampled at sites around the South West Peninsula of England in 1986, and analysed for allozyme variation at 18 enzyme loci. Two of these loci, αGpd-1 andHk-1, exhibited sex-specific phenotypes. An absolute locus association was observed between two other loci,Mdh-1 andEst-3. This association was only found at one site (Prawle), and it is suggested that the presence of chromosomal polymorphisms could explain this finding. As a measure of overall similarity, Nei's genetic identity statistic,I, was calculated; the mean for all populations was 0.989, with values ranging from 0.981 to 0.997. Although similar on this gross level, considerable interpopulation variation was evident. Observed mean heterozygosity (per locus) ranged from 0.043 to 0.104 (mean 0.074). Populations differed also in the loci at which significant heterozygote deficits were seen (of the seven deficits recorded only those at thePep-1 locus were consistent across sites) and in the presence of rare alleles undetected elsewhere. The variation observed showed no correlation to shell morphology or geographical distance and confirmed the conclusion that species of the genusNucella show considerable disjunct variation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644981
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of hypertension on the in vitro incorporation of [1-14C]-oleate into phospholipid and cholesterol ester in the aortae of normal-fed and cholesterol-fed rabbits (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 283-288 
    Details
    ISSN: 1432-1440
    Keywords: Atherogenese ; Arterieller Hochdruck ; Cholesteringefütterten Kaninchen ; Cholesterin-Ester ; Phospholipide ; Atherogenesis ; Hypertension ; Cholesterol-fed rabbits ; Cholesterol Ester ; Phospholipid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effect of prior hypertension on the in vitro incorporation of [1-14C]-oleate into phospholipid and cholesterol ester in aortae from cholesterolfed and normal fed rabbits was studied. Incorporation of [1-14C]-oleate into phospholipid was not increased in aortae from either hypertensive normal-fed or hypertensive cholesterol-fed rabbits when compared to the appropriate normotensive controls. In the normal-fed rabbits, incorporation of [1-14C]-oleate into cholesterol ester was increased by hypertension in all aortic regions. In cholesterol-fed rabbits cholesterol esterification was found to be proportional to the intimal cholesterol concentration, irrespective of the prior blood pressure or the particular aortic region studied. It is concluded that the increased lipid synthesis in atherosclerotic vessels from hypertensive rabbits is a consequence of the increased lipid accumulation produced by hypertension and not the result of hypertension directly stimulating arterial wall metabolism.
    Notes: Zusammenfassung Der Einfluß von früherem arteriellen Hochdruck auf den in-vitro Einbau (1-14C)-Oleat in Phospholipide und Cholesterin-Ester in Aorten von Cholesterin-gefütterten und normal-gefütterten Kaninchen wurde untersucht. Im Vergleich zu den respektiven normotensiven Kontroll-Tieren stieg der Einbau (1-14C)-Oleat in Phospholipide in Aorten von hypertensiv normal-gefütterten und hypertensiv Cholesterin-gefütterten Kaninchen nicht an. In normal-gefütterten Kaninchen wurde der Einbau der (1-14C)-Oleat in allen Gegenden der Aorta mit Hochdruck vermehrt. Bei Cholesterin-gefütterten Kaninchen wurde die Cholesterin-Ester-Synthese der jeweiligen intimalen Cholesterin-Konzentration angemessen, unabhängig von welcher Aorten-Gegend untersucht wurde oder von der Höhe des früheren Blutdrucks. Daraus folgert, daß die gesteigerte Lipid-Synthese in atherosklerotischen Gefäßen hypertensiver Kaninchen eine Folge gesteigerter Lipidanhäufung ist, und nicht auf einen vom Hochdruck direkt vermehrten Arterienwandstoffwechsel zurückzuführen ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484729
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  • 5
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    Unknown
    City Region and Regionalism (R. E. Dickinson) (Book Review) (1948)
    Sydney, N.S.W. : Periodicals Archive Online (PAO)
    Australasian Journal of Philosophy. 26 (1948) 64 
    Details
    ISSN: 0004-8402
    Topics: Philosophy
    Notes: REVIEWS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4251-1948-026-00-000014
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  • 6
    Electronic Resource
    Electronic Resource
    Sequence analysis of a cDNA clone encoding the C-terminal end of human complement factor H (1987)
    Springer
    Bioscience reports 7 (1987), S. 201-207 
    Details
    ISSN: 1573-4935
    Keywords: complement ; factor H ; protein sequencing ; cDNA sequencing ; homology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Peptide sequencing of the complement system regulatory protein, factor H, permitted the synthesis of a mixed sequence oligonucleotide probe. Human liver cDNA libraries were screened and factor H-specific clones selected. No full-length clone was obtained, but the largest available clone, R2a, was found to encode the C-terminal 657 amino acids of factor H. The derived amino acid sequence consists of 10 contiguous internally homologous segments, each about 60 amino acids long. Sequences homologous to these are found in several other complement and non-complement proteins. Such sequences are likely to represent a particular type of tertiary structure subunit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01124790
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  • 7
    Electronic Resource
    Electronic Resource
    Partial characterization of human complement factor H by protein and cDNA sequencing: Homology with other complement and non-complement proteins (1986)
    Springer
    Bioscience reports 6 (1986), S. 65-72 
    Details
    ISSN: 1573-4935
    Keywords: complement ; factor H ; C4b-binding protein, C2, factor B ; β2-glycoprotein ; interleukin-2 receptor ; sequence homology ; cDNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Factor H, a control protein of the human complement system, is closely related in functional activity to two other complement control proteins, C4b-binding protein (C4bp) and complement receptor type 1 (CR1). C4bp is known to have an unusual primary structure consisting of eight homologous units each about 60 amino acids long. Such units also occur in the N-terminal regions of the complement proteins C2 and factor B, and in the non-complement serum glycoprotein β2I. Amino acid sequencing, and sequencing of a factor H cDNA clone, show that factor H also contains internal repeating units, and is homologous to the proteins listed above.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01145180
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