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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 93-124 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis complements the information provided by the generation of genetic defects in mice created using homologous recombination techniques. In this review, the recent findings made in three areas are focused upon deficiencies in T cell differentiation and in T lymphocyte activation, and on the control process of peripheral immune response.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: GM-CSF induces proliferation and activation of Langerhans’ cells in vitro. The density of Langerhans’ cells in human tumours is correlated to the in situ density of GM-CSF, and intradermal injection of GM-CSF induces local accumulation of Langerhans’ cells. Therefore, we investigated the presence of GM-CSF in the sera of children with Langerhans’ cell histiocytosis (LCH). We detected GM-CSF in the sera of all children with disseminated and active LCH, but not in the sera of patients with localized (i.e. bone) LCH. These results suggest that GM-CSF level is related to extent and the activity of LCH.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Rock mechanics and rock engineering 5 (1973), S. 189-202 
    ISSN: 1434-453X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Description / Table of Contents: Zusammenfassung Neues digitales Verfahren zur dreidimensionalen Spannungsanalyse in elastischen Medien In der vorliegenden Arbeit werden die Grundlagen eines neuen Verfahrens der dreidimensionalen Spannungsanalyse beschrieben. Die Behandlung des allgemeinen Problems der Gebirgsmechanik, d. h. die Bestimmung der Spannungs- und Verschiebungsverteilungen in der Umgebung von untertägigen Hohlräumen, mit Hilfe konventioneller Verfahren — wie z. B. der Methode der Finiten Elemente — hat den Nachteil, daß der gesamte Gebirgskörper berücksichtigt werden muß. Dies hat zur Folge, daß sich realistische dreidimensionale Probleme auch mit modernsten Digitalrechnern nicht mehr innerhalb annehmbarer Rechenzeiten lösen lassen. Das hier vorgestellte Verfahren vermeidet diese Schwierigkeiten durch eine Formulierung, die ausschließlich die Randbedingungen an den Begrenzungsflächen des Mediums verwendet. Spannungen und Verschiebungen an diesen Flächen sowie im Inneren des Gebirgskörpers werden als Überlagerungseffekt einer Reihe von Grund-Lösungen mit geeigneten Eigenschaften ausgedrückt. Aus Gründen der Einfachheit wird in dieser Arbeit nureine solche Grund-Lösung verwendet. Diese beschreibt die Wirkungen einer Einzelkraft, die an einem Punkt eines unendlichen Mediums angreift. Mit Hilfe dieser Lösung kann die Wirkung eines Aggregates derartiger Kräfte in Matrizenform ausgedrückt werden. Läßt man eine Einzelkraft an jedem infinitesimalen Element einer kontinuierlichen Fläche angreifen, dann können die Spannungs- und Verschiebungsverteilungen im Körper mit Hilfe der an dieser Fläche herrschenden Randbedingungen beschrieben werden. Begrenzt die Fläche einen geschlossenen Hohlraum, so trennt sie das Medium in einen inneren und einen äußeren Teil. Auf diese Art entstehen zwei Problemklassen: Während der innere Bereich die Spannungsanalyse von Ingenieurbauten beinhaltet, entspricht der äußere Bereich dem Hohlraumproblem der Gebirgsmechanik. Die beschriebene Formulierung mittels Matrizen ist für beide Bereiche gültig. Es wird jedoch gezeigt, daß die entsprechenden Matrizen charakteristisch unterschiedliche Eigenschaften haben. Diese Beobachtung ist von grundlegender Bedeutung für die Entwicklung numerischer Lösungsverfahren. Die Konvergenz-Charakteristiken zweier Iterativ-Schemata werden in Betracht gezogen. Zusammenfassend wird noch einmal die generelle Gültigkeit des Verfahrens betont. Weitere Grund-Lösungen und ihre Anwendung auf spezielle Probleme werden erwähnt.
    Abstract: Résumé Une nouvelle méthode pour la solution de problèmes à trois dimensions dans la théorie de l'élasticité Les auteurs élaborent une nouvelle méthode pour la solution de problèmes à trois dimensions dans la théorie de l'élasticité. En Mécanique des Roches, lorsque les excavations sont situées dans une masse infinie de roches, les méthodes courantes, telle que les éléments finis, ont le désavantage d'avoir à opérer sur une quasi-infinité d'éléments. Il en résulte que l'analyse de configurations réelles à trois dimensions devient impossible même avec les plus grands ordinateurs modernes. La nouvelle méthode évite ces difficultés en reformulant le problème entièrement en fonction des conditions régnant aux limites de la configuration. Les tensions et les déplacements aux limites, ainsi qu'à l'intérieur de la masse, sont produits par les actions superposées d'un ensemble convenablement choisi de fonctions — solutions élémentaires. Pour alléger l'exposé on n'a employé qu'une seule fonction — solution dans cette publication. Elle décrit l'action d'une force concentrée en un point d'un milieu infini. Les actions d'une distribution de pareilles forces concentrées peuvent s'exprimer sous forme matricielle. En appliquant une force concentrée à chaque élément infinitésimal d'une surface continue située dans le milieu on arrive à exprimer les tensions et les déplacements en un point quelconque en fonction des conditions régnant sur cette surface. Si cette surface est fermée elle divise le milieu en une région intérieure et une région extérieure, ce qui donne lieu a deux classes de problèmes. Le problème intérieur se présente surtout en Résistance des Matériaux, tandis que le problème extérieur se recontre en Mécanique des Roches. Le formalisme matriciel mentionné ci-dessus est applicable dans les deux régions. Cependant il apparaît que les matrices associées ont des propriétés foncièrement différentes. Cette constatation est de première importance lors de l'élaboration de méthodes de solutions numériques ayant recours à l'ordinateur. Deux procédés de calculs appropriés sont analysés dans cette publication. Dans leurs conclusions les auteurs mettent de nouveau en relief la généralité de la méthode. Quelques exemples de fonctions — solutions élémentaires, différentes de la fonction — solution (force concentrée) employée dans cette publication, sont cités.
    Notes: Summary A New Digital Method for Three-Dimensional Stress Analysis in Elastic Media A new method for three-dimensional stress analysis in elastic media is outlined. According to this approach the problem is formulated purely in terms of conditions prevailing at the bounding surfaces of an elastic body. Stress and displacements on these surfaces, as well as inside the body, are expressed in terms of the superimposed effect of a set of basic solutions having suitable properties. The method is developed in matrix form. Some general properties of the governing matrices are established with a view to developing suitable numerical procedures. The convergence characteristics of two iterative schemes are considered. The paper concludes with observations concerning the generality of the approach.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Hematology and cell therapy 39 (1997), S. 269-273 
    ISSN: 1279-8509
    Keywords: Immunodeficiency ; Viral complications ; Adenovirus ; CMV ; EBV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients undergoing bone marrow transplantation are susceptible to many different bacterial, fungal and viral infections. Among the viral pathogens, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus cause the greatest morbidity and mortality and have been the most common infectious causes of death following the grafting of allogeneic marrow. This great susceptibility to viral infections is due to the immunodeficiency in cellular and humoral immune responses lasting for months to years. Contributing factors are high-dose chemo/radiotherapy, graft-versus-host disease (GVHD) prophylaxis/treatment, GVHD itself, the degree of HLA disparity between donor and recipient and the underlying disease. Defects of T cell helper and cytotoxic functions contribute to the great incidence of viral infections. We described here the kinetic of immunological reconstituion and the role of T cell immunodeficiency. At day 30 to 40 after BMT, a minority of patients had recovery of virus-specific CD8+ T-cell response. Between day 40 and day 90 recovery of deficient CD8+ and CD4+ T cell responses occured in the majority of the recipients of HLA identical BMT but only in the minority of the recipients of HLA partially incompatible BMT. New approaches should therefore be envisaged either to preserve donor T-cell-mediate immunity or tho accelerate immune reconstitution. Add-back of unmanipulated T-cells, or virus-specific T cells could improve antimicrobial defenses after BMT.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0584
    Keywords: Linkage study ; Pattern of X-inactivation ; Carrier determination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary While inherited X-linked (XL) isolated thrombocytopenia is a mild condition, the Wiskott-Aldrich syndrome (WAS) associates severe thrombocytopenia with an immunodeficiency component and has a poor prognosis. Whether these conditions correspond to separate genetic entities or to different mutations of the same gene(s) remains unresolved. The Wiskott-Aldrich syndrome locus has been assigned to Xp 11.2 by means of RFLP studies. The X-inactivation pattern in female carriers has been found to follow a skewed pattern in the hematopoietic cells, thus allowing carrier detection. We studied a family with four members affected by XL thrombocytopenia and report the results of genetic segregation analysis, together with the X-inactivation pattern of hematopoietic cells from an obligate female carrier. Although the affected locus mapped to the same region as that of WAS, lymphocytes presented a skewed pattern of X-inactivation, whereas polymorphonuclear lymphocytes (PMN) did not. These results provide further evidence that the Wiskott-Aldrich syndrome and XL thrombocytopenia are different expressions of mutations within a single locus and that the severity of the disease corresponds to distinct hematopoietic cell selections in obligate carriers.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Keywords: Insulin receptor ; tyrosine kinase ; insulin-like activity ; antibodies to insulin receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Severe hypoglycaemia developed seven months after a bone marrow transplantation in a child with severe combined immunodeficiency. His serum exerted potent insulin-like activity: (a) it stimulated insulin receptor autophosphorylation and kinase activity in cell-free systems, this effect being additive to insulin; (b) it increased glucose transport in isolated soleus muscle. These insulin-like effects were due to immunoglobulins against the insulin receptor. Indeed, the patient serum immunoprecipitated human or murine insulin receptors from different tissues and inhibited insulin binding to receptor on human IM-9 lymphocytes. After corticoids and immunosuppressive therapy by azathioprine, the patient hypoglycaemic episodes disappeared, and concomitantly, the antibodies to insulin receptor were no longer detected, as judged by both immunoprecipitation of insulin receptor and stimulation of glucose transport.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 90 (1993), S. 663-665 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In a series of ten patients affected by DiGeorge syndrome, we screened, by high resolution banding and fluorescent in situ hybridization of a cosmid probe, for microdeletions associated with this syndrome. In the ten patients, a microdeletion was demonstrated by in situ hybridization, but suspected only in two patients by high resolution banding.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Springer seminars in immunopathology 19 (1998), S. 479-492 
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Springer seminars in immunopathology 19 (1998), S. 479-492 
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-2592
    Keywords: Chronic mucocutaneous candidiasis ; mannan ofCandida albicans ; mannan-induced T- and B-cell responses ; specific T suppressive activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have studied T- and B-cell responses to antigens ofCandida albicans in 18 patients suffering from chronic mucocutaneous candidiasis. We have shown thatin vitro production of antibody to one of these antigens, mannan, was absent during the active phase of the disease and that this absence was consequent to the activation of specific CD8(+) and CD8(−) suppressor T lymphocytes. Such activation was also observed when control T lymphocytes were incubated in the presence of monocytes and a high concentration of mannan. This suppressive effect was specific to antigens ofCandida albicans, was radiosensitive, and was not consequent to the secretion of prostaglandin E2. It appeared as well that the induction of these suppressor T cells was HLA-DQ restricted. The suppressor T-cell activity induced by antigens ofCandida albicans in vitro is thus comparable to the suppressor T-cell activity observedin vivo in patients affected with chronic mucocutaneous candidiasis. Defective handling of mannan by monocytes could result in the accumulation of mannan, resulting in the activation of specific T suppressor cells and in the consequent cellular immunodeficiency specific toCandida albicans. Successful treatment of the candidiasis resulted in complete correction of the immune abnormalities.
    Type of Medium: Electronic Resource
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