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  • 1
    Electronic Resource
    Electronic Resource
    Non-invasive evaluation of inflammation in atopic dermatitis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 3 (1994), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In atopic dermatitis the inflammatory reaction is quantified either clinically or histologically. While clinical evaluation has the major disadvantage of inter- and intraoperator variance, histological investigation requires invasive procedures. Therefore, standard techniques which provide both an objective and non-invasive form of examination are desirable.We investigated 20 patients with atopic dermatitis by means of high resolution 20-MHz b-*scan ultrasound. Investigations were performed on inflammatory skin lesions at regular intervals using a standardized combination of external treatment with α-methyl-prednisolon-aceponat ointment and UV-A/UV-B phototherapy until the lesions had healed. Skin colour (erythema) was assessed with the Minolta Chromameter CR 200 colorimeter according to the L*a*b* colour system.Sonograms of affected skin show a zone of low echogenicity below the so-called entry-echo. We refer to this as the echolucent area. Healing of a lesion is seen as a decrease in thickness and an increase in density of the skin in the sonographic image; the echolucent area disappears totally when the lesion has clinically healed. In five patients we excised small areas of skin to compare the sonographic and histological pictures of exactly the same site. This showed that the thickness of the subepidermal echolucent area corresponds to the inflammatory reaction representing both edema and cellular infiltration.Comparing the findings in sonography with the change in skin colour measurements we found that the a*-value of the L*a*b* colour system representing redness correlated well with the sonographic density of the echolucent area. In conclusion, 20-MHz-b-scan sonography and colorimetry are suitable methods for non-invasive, objective evaluation of the inflammatory process in atopic dermatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1994.tb00374.x
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  • 2
    Electronic Resource
    Electronic Resource
    Twenty MHz B-scan sonography for visualization and skin thickness measurement of human skin (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 3 (1994), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: As a non-invasive method, ultrasound is a suitable diagnostic procedure for routine in vivo examination of the human skin in dermatology. In this study 40 healthy test subjects were examined with a 20-MHz ultrasound scanner in order to determine the thickness and morphology of normal skin at 51 different sites. B-mode ultrasonography permits us to measure both the individual layers of the skin and deeper structures and to assess their definition and echogenicity. In both sexes the greatest skin thicknesses were found on: the shoulder-blade (mean thicknesses (mm), males 3.07/ females 2.47); the upper back (m, 3.04/f, 2.85); the chin (m, 3.04/f, 2.69); the lower lip (m, 2.66/f,2.50) and in the region of the lower back (m, 2.64/f, 2.39). Particularly thin skin was found on: the upper eyelid (m, 0.59/f, 0.64); the lower eyelid (m, 0.99/f, 0.86); in the groin (m. 0.97/f, 0.90); in the armpit (m, 1.01/f, 1.09) and on the forearm (m, 1.13/f. 1.00 mm). Knowledge of differences in the characteristic reflex patterns depending on the sex and age of the subject and the site of the skin examined forms the basis for assessment of pathological sonograms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1994.tb00367.x
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  • 3
    Electronic Resource
    Electronic Resource
    Contact allergy to 8-methoxypsoralen (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 30 (1994), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 36-year-old female patient was treated with PUVA for dyshidrotic eczema that had not shown sufficient response to topical therapy over the previous months. PUVA therapy caused acute aggravation of the eczema. Patch testing demonstrated Type IV sensitization to 8-methoxypsoralen in Meladinine solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1994.tb00599.x
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  • 4
    Electronic Resource
    Electronic Resource
    Erfolgreiche Monotherapie der hypereosinophilen Dermatitis mit PUVA-BadPhotochemotherapie (1997)
    Springer
    Der Hautarzt 48 (1997), S. 820-823 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Hypereosinophile Dermatitis ; PUVA-Badphotochemotherapie ; Langzeittherapie ; Key words Hpyereosinophilic dermatitis ; PUVA-bath photochemotherapy ; Long-term treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 70-year-old woman with long-standing hypereosinophilic dermatitis improved strikingly with PUVA-bath photochemotherapy. The single UVA doses ranged from 0.3 to 3.3 J/cm2. After 19 treatment sessions pruritus disappeared, and after 32 treatments the erythematous maculus completely cleared. Under continuous treatment three times a week, no relapse has ocurred to date. PUVA-bath photochemotherapy seems to be a promising new treatment modality without systemic side effects for patients with hypereosinophilic dermatitis.
    Notes: Zusammenfassung Eine 70jährige Patientin mit einer seit über 2 Jahren bestehenden hypereosinophilen Dermatitis wurde mit einer PUVA-Badphotochemotherapie über insgesamt 1 Jahr behandelt. Die 8-Methoxypsoralenkonzentration im Badewasser betrug 0,5 mg/l, unmittelbar im Anschluß an das Psoralenvollbad erfolgte die Bestrahlung mit UVA. Die kumulative UVA-Dosis der gesamten Behandlung betrug 245 J/cm2. Bereits nach 19 Behandlungen kam es zu einer deutlichen Besserung des Juckreizes und nach 32 Behandlungen zu einem vollständigen Rückgang der erythematischen Maculae. Während der Erhaltungstherapiephase über weitere 44 Wochen sowie im Verlauf der bislang 5monatigen Nachbeobachtungszeit kam es zu keinem Rezidiv. Aufgrund der fehlenden systemischen Nebenwirkungen und der guten therapeutischen Wirksamkeit stellt die PUVA-Bad-Photochemoterapie eine neue therapeutische Alternative in der Behandlung der hypereosinophilen Dermatitis dar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050667
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Bleomycin-induzierte PSS- artige Pseudosklerodermie Fallbericht und Revision der Literatur (1998)
    Springer
    Der Hautarzt 49 (1998), S. 725-729 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Bleomycin ; Pseudosklerodermie ; Pathogenese ; Therapiemodalitäten ; Literaturrevision ; Key words Bleomycin ; Scleroderma ; Pathogenesis ; Treatment modalities ; Review of the literature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Although the association between administration of the antitumor agent bleomycin and the development of cutanous fibrosis is established, there are only a small number of cases of bleomycin-induced scleroderma described in the literature. We report the development of generalised scleroderma with wide spread hyperpigmentation in a 52-year-old male patient, who received a total dose of 360 mg bleomycin in combination with cisplatin and etoposid for therapy of a malignant testicular seminoma. The clinical cutaneous alterations as well as the histological findings were indistinguishable from those encountered in progressive systemic sclerosis (PSS). In contrast to PSS however, Raynaud’s phenomenon, cutaneous calcinosis, teleangiectasia, arthritis and involvement of additional organs were all absent. PSS-typical auto-antibodies were negative. Even 18 months after discontinuation of the drug and treatment with UVA1 phototherapy (3–4 times per week with 20 J/cm2) as well as physiotherapy, the skin changes had still not resolved. Based on our case and a detailed review of the literature, we discuss characteristics of bleomycin-induced scleroderma including pathogenesis, treatment modalities and course.
    Notes: Zusammenfassung Obwohl der Zusammenhang zwischen Bleomycinapplikation und der Entwicklung einer Pseudosklerodermie wissenschaftlich bestätigt ist, existieren bisher nur wenige Fallberichte in der Literatur. Wir berichten kasuistisch über einen 52jährigen Patienten, der nach Einnahme einer Bleomycindosis von insgesamt 360 mg in Kombination mit Cisplatin und Etoposid aufgrund eines Seminoms des Hodens eine PSS (Progressive Systemische Sklerodermie) -artige Pseudosklerodermie mit flächigen Hyperpigmentierungen entwickelte. Histologisch entsprach das Krankheitsbild einer PSS; Raynaud-Syndrom, Calcinosis cutis, Teleangiektasien, Arthritis oder Beteiligung innerer Organe bestanden jedoch nicht. PSS-typische Autoantikörper waren nicht nachweisbar. In dem 18monatigen Beobachtungszeitraum nach Absetzen der Bleomycinmedikation kam es trotz intensiver UVA1-Phototherapie (3- bis 4mal wöchentlich je 20 J/cm2) sowie Physiotherapie nicht zur Abheilung der sklerotischen Hautveränderungen. Anhand eigener Erfahrungen und einer detaillierten Revision der Literatur werden die Charakteristika der Bleomycin-induzierten Pseudosklerodermie einschließlich ihrer Pathogenese, der Therapiemodalitäten und des Verlaufes diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050817
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