ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Searching for RET/PTC rearrangements and BRAF V599E mutation in thyroid aspirates might contribute to establish a preoperative diagnosis of papillary thyroid carcinoma (2005)

Domingues, R. ; Mendonça, E. ; Sobrinho, L. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Cytopathology 16 (2005), S. 0

add to mindlist on the mindlist

Details

ISSN: 1365-2303

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Objective: Searching for multiple molecular markers in thyroid aspirates appears to be a promising approach for establishing a preoperative diagnosis of papillary thyroid carcinoma (PTC).Methods: Based on this hypothesis, a total of 63 samples from 55 patients, were collected at random. RNA was extracted from the residue cells inside the needle used for fine needle aspiration cytology (FNAC) and thereafter molecular analysis was carried out both for RET rearrangements (type 1, 2, 3) and BRAF codon 599 mutation molecule. Results were compared with the cytological and histopathological diagnoses in 24 patients submitted to surgery.Results: 58% PTCs presented a genetic alteration either RET/PTC rearrangement, BRAF V599E mutation or both: three cases of PTCs (25%) presented a RET/PTC rearrangement; three cases of PTCs (25%) presented a BRAF V599E mutation and in one case (8%) both alterations were identified.Conclusions: The present results suggest that searching for multiple molecular markers in thyroid aspirates may enhance the accuracy of FNAC and refine preoperative diagnosis of PTC.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2303.2004.00223.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Hydroxyapatite–zirconia composites preparedby precipitation method (1997)

SILVA, V. V ; DOMINGUES, R. Z

Springer

Journal of materials science 8 (1997), S. 907-910

add to mindlist on the mindlist

Details

ISSN: 1573-4838

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine , Technology

Notes: Abstract Chemical routes to prepare ceramic precursor powders are frequently envisaged, especially when the aspects related to the microstructure are important and need to be controlled. An understanding of which parameters of synthesis and thermal treatment can influence the mechanical properties of hydroxyapatite compounds is essential for the production of such materials. Hydroxyapatite–zirconia composites have been prepared, in this study, by a precipitation method. This led to the formation of homogeneous powders with a very defined particle-size distribution. Ceramic pellets prepared from these powders were easily compacted and sintered without cracking. As expected, the presence of the zirconia phase improved composite densities and appeared to have an important role in thermal stabilization of the hydroxyapatite phase.