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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Primary Metabolites on Secondary Metabolism (1977)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 31 (1977), S. 343-356 
    Details
    ISSN: 0066-4227
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.mi.31.100177.002015
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The obligatory role of methionine in the conversion of sulfate to cephalosporin C (1975)
    Springer
    Applied microbiology and biotechnology 1 (1975), S. 121-128 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Cephalosporium acremonium CW 19 produces cephalosporin C from sulfate; production is increased by addition of methionine, a source of sulfur for the antibiotic. Mutation to methionine auxotrophy eliminates the ability to produce antibiotic at low methionine concentration (30–80 μg DL-methionine per ml) despite normal growth and the presence of excess sulfate for antibiotic synthesis. Thus cephalosporin C biosynthesis from sulfate by the parent culture involves some obligatory role of endogenous methionine, probably a non-precursor role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00942209
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    On-line analysis of avermectin fermentation cell growth kinetics in an industrial pilot plant (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 34 (1989), S. 234-241 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Experimental data are presented which show that on-line calculation of oxygen uptake rate can be used to estimate the cell concentration of Streptomyces avermitilis during the active growth phase of this fermentation. Moreover, by dividing the oxygen uptake rate by the total oxygen consumed, an on-line estimate of specific growth rate of this culture can be generated. A theoretical basis is provided for this model. Use of a mass spectrometer for vent gas analysis coupled with computer data acquisition has made this information both very accurate and readily available. Examples are given which illustrate the kinetics of the avermectin fermentation as well as the effect of a temperature shift on the specific growth rate.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260340212
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Thienamycin production by immobilized cells of Streptomyces cattleya in a bubble column (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 25 (1983), S. 2399-2411 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A novel 2.0-L columnar reactor has been developed for the production of thienamycin by cells of Streptomyces cattleya attached to celite particles. Successful immobilization of cells was achieved by operating the column continuously at a high dilution rate during the growth phase. Scanning electron micrographs of the celite particles indicate the involvement of subcellular fibrils in the attachment of cells to the solid surfaces. Reactor operation was divided into two distinct phases-a growth phase and a production phase. The kinetics of attached growth and thienamycin production were found to be strongly influenced by nutrient concentrations. The influences of nutrient concentration on CO2 production and thienamycin production during both the growth phase and the production phase are discussed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260251010
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    Paper (German National Licenses)
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